What is the recommended dosage for 5-HTP?

General: 50-100 mg 1-3x/day; Starting: 50 mg/day and titrate up; Appetite Control: 250-300 mg/day 30 min before meals

What are the side effects of 5-HTP?

Potential side effects include: Nausea, Drowsiness, GI discomfort, Serotonin syndrome risk with contraindicated medications.

5-HTP

fiber_satiety

Also known as: 5-Hydroxytryptophan, Griffonia simplicifolia Extract, Oxitriptan

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About

The immediate precursor to serotonin (5-HT) derived from Griffonia simplicifolia seeds. 5-HTP crosses the blood-brain barrier and may support healthy appetite regulation by modulating hypothalamic satiety centers and reducing carbohydrate cravings.

How It Works

Immediate precursor to serotonin (5-HT) that crosses the blood-brain barrier. Elevated brain serotonin levels activate hypothalamic satiety centers, reducing appetite and carbohydrate cravings. Serotonin also modulates reward pathways involved in emotional and hedonic eating behaviors.

Evidence For Conditions

Condition	Grade	Studies	Participants
Appetite Control	C	4	100	View →
Emotional Eating	C	3	80	View →

Side Effects

Nausea
Drowsiness
GI discomfort
Serotonin syndrome risk with contraindicated medications

Drug & Supplement Interactions

SSRIs (serotonin syndrome risk — NEVER combine)
SNRIs (serotonin syndrome risk — NEVER combine)
MAOIs (serotonin syndrome risk — NEVER combine)
Triptans (serotonin syndrome risk)
Carbidopa

Always inform your healthcare provider about all supplements you take.

Related Ingredients

Chromium Glucomannan Psyllium White Kidney Bean Extract

Quick Facts

Dosage: General: 50-100 mg 1-3x/day; Starting: 50 mg/day and titrate up; Appetite_Control: 250-300 mg/day 30 min before meals
Forms: capsule tablet
Natural Sources: Griffonia simplicifolia seeds (West African shrub)
Upper Limit: 500 mg/day; avoid combining with SSRIs, SNRIs, MAOIs, or triptans (serotonin syndrome risk)
Best Time: 30 minutes before meals on an empty stomach

Evidence Summary

Appetite Control C

Emotional Eating C

FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.