Evidence-Based Supplement Reviews
Every weight claim cited.
We read the weight management studies so you don't have to.
Evidence-based supplement research you can trust. We analyze peer-reviewed clinical studies from PubMed and grade every supplement ingredient on a transparent A–D scale. No sponsored rankings, no manufacturer influence — just science.
Featured Ingredients
Ashwagandha
hormonalWithanolide-rich adaptogen that modulates the hypothalamic-pituitary-adrenal (HPA) axis, reducing cortisol levels by 14-28% in clinical trials. Chronic cortisol elevation promotes …
Berberine
fat_metabolismActivates AMP-activated protein kinase (AMPK), the master metabolic regulator, in muscle, liver, and adipose tissue — a mechanism shared with …
Glucomannan
fiber_satietyWater-soluble dietary fiber that absorbs up to 50 times its weight in water, forming a viscous gel in the stomach. …
Green Tea Extract (EGCG)
thermogenicEpigallocatechin gallate (EGCG) inhibits catechol-O-methyltransferase (COMT), prolonging norepinephrine signaling and increasing thermogenesis and fat oxidation. Also activates AMPK, which promotes …
Probiotics (Lactobacillus gasseri)
gut_healthStrain-specific probiotic that modulates the gut-brain-adipose axis. L. gasseri SBT2055 reduces dietary fat absorption by increasing fecal fat excretion (by …
Vitamin D
hormonalVitamin D receptors are expressed in adipose tissue, skeletal muscle, and the pancreas. Adequate vitamin D status supports insulin sensitivity, …
Top Conditions
Abdominal Fat Reduction
54% of US adults have elevated waist circumference; visceral obesity increasing even among normal-weight individuals
Appetite Control
Subjective hunger and appetite dysregulation affect the majority of individuals attempting weight loss
Insulin Resistance
40% of US adults aged 18-44 (estimated); up to 70% in obese individuals
Metabolic Syndrome
34.7% of US adults (NHANES); increases with age: 50% in those >60 years
Obesity
42.4% of US adults (2023 CDC data); 650 million adults globally; prevalence has tripled since 1975
Overweight Management
30.7% of US adults; combined with obesity, 73.1% of US adults are overweight or obese
Recent Evidence Updates
Latest Research
Arch Intern Med · 2009
Association between serum 25-hydroxyvitamin D level and upper respiratory tract infection in the Third National Health and Nutrition Examination Survey.
Am J Clin Nutr · 2000
Prebiotics and probiotics: are they functional foods?
J Cachexia Sarcopenia Muscle · 2020
Osteosarcopenia: epidemiology, diagnosis, and treatment-facts and numbers.
Am J Gastroenterol · 2007
Imbalances in dietary consumption of fatty acids, vegetables, and fruits are associated with risk for Crohn's disease in children.
Am Fam Physician · 2017
Vitamin B12 Deficiency: Recognition and Management.
Am J Clin Nutr · 2000
Selected herbals and human exercise performance.
Guides & Resources
Managing Weight Loss Plateaus: Science and Strategies
Weight loss plateaus are among the most frustrating and misunderstood aspects of the weight management journey, yet they are a near-universal experience and a physiologically …
lifestyleExercise and Supplements: An Evidence-Based Approach
Regular physical activity is the single most impactful modifiable factor for long-term weight management success. Meta-analyses of weight loss maintenance studies consistently show that individuals …
safetyWeight Loss Supplement Interactions with Medications
Drug-supplement interactions represent one of the most underappreciated safety concerns in weight management. A 2016 survey published in JAMA Internal Medicine found that more than …
Evidence Grading System
Every supplement claim on this site is graded on an A–D scale based on peer-reviewed clinical research from PubMed. Our algorithm evaluates study design (RCTs rank highest), consistency of results, sample sizes, and the overall body of evidence. No manufacturer sponsorship influences our grades.
Multiple randomized controlled trials (RCTs) or meta-analyses with consistent positive results and large sample sizes.
At least one RCT with mostly consistent results across studies. Evidence suggests benefit but more research may be needed.
Small studies or observational data with some positive signals. Promising but insufficient for strong recommendations.
In vitro studies, case reports, or pilot studies only. Early-stage research that requires clinical validation.
How It Works
No ads. No sponsored rankings. Just science.
Search PubMed
We search PubMed for every clinical study on supplement ingredients.
Extract Findings
We extract the key findings — sample sizes, study types, and results.
Grade A through F
We grade the evidence like a school report card — from A (strong) to F (negative).
Clear Answer
You get a clear answer in seconds — does this supplement actually work?
Cited Health Network
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FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.