What is the recommended dosage for Capsaicin?

Cayenne: 1-2 g dried pepper/day; General: 2-6 mg capsaicinoids/day; Concentrated Extract: 30-135 mg capsinoids/day

What are the side effects of Capsaicin?

Potential side effects include: GI burning and discomfort, Heartburn, Stomach irritation.

What is capsaicin and how may it support weight management?

Capsaicin is the compound responsible for the heat in chili peppers. Some clinical research suggests it may slightly increase energy expenditure and reduce appetite through thermogenic effects. These statements have not been evaluated by the FDA.

What dosage of capsaicin has been studied in clinical trials?

Clinical studies have used capsaicin doses ranging from 2 to 6 mg per day, often in capsule form to avoid oral irritation. Some studies used capsinoid forms, which are non-pungent analogs, at doses of 6–12 mg daily for 4–12 weeks.

What are the potential side effects of capsaicin supplements?

Common side effects include gastrointestinal discomfort, heartburn, stomach pain, and nausea. Capsaicin may exacerbate gastroesophageal reflux. Individuals with irritable bowel syndrome or peptic ulcers should exercise caution and consult a healthcare provider.

Capsaicin

thermogenic

Also known as: Capsaicinoids, Cayenne Pepper Extract, Capsicum Extract, Dihydrocapsiate

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About

The primary pungent compound in chili peppers that activates TRPV1 channels to stimulate thermogenesis and enhance fat oxidation. Meta-analyses demonstrate capsaicinoids may support modest increases in energy expenditure and help promote healthy appetite regulation.

How It Works

Activates transient receptor potential vanilloid 1 (TRPV1) channels, stimulating sympathetic nervous system activity and brown adipose tissue thermogenesis. Increases energy expenditure, enhances fat oxidation, and may reduce appetite through GLP-1 and decreased ghrelin signaling.

Evidence For Conditions

Condition	Grade	Studies	Participants
Fat Oxidation Enhancement	B	12	563	View →

Side Effects

GI burning and discomfort
Heartburn
Stomach irritation

Drug & Supplement Interactions

Anticoagulants (theoretical)
Antihypertensives
ACE inhibitors (cough exacerbation)

Always inform your healthcare provider about all supplements you take.

Related Ingredients

Caffeine Forskolin Green Tea Extract (EGCG) Synephrine

Quick Facts

Dosage: Cayenne: 1-2 g dried pepper/day; General: 2-6 mg capsaicinoids/day; Concentrated_Extract: 30-135 mg capsinoids/day
Forms: capsule powder extract enteric-coated tablet
Natural Sources: Chili peppers (cayenne, habanero, jalapeño), Paprika (mild form)
Upper Limit: No established UL; GI discomfort limits intake
Best Time: With meals; enteric-coated forms reduce GI burning

Evidence Summary

Fat Oxidation Enhancement B

FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.