What is the recommended dosage for Hoodia?

General: No established effective dose; Marketed: 400-1,000 mg/day (no clinical basis)

What are the side effects of Hoodia?

Potential side effects include: Elevated liver enzymes, Elevated blood pressure, Elevated heart rate, Nausea, Skin reactions.

What is hoodia and how may it relate to weight management?

Hoodia gordonii is a succulent plant from southern Africa traditionally used by San Bushmen to suppress hunger during long hunts. Despite early interest, clinical trials have not demonstrated significant appetite-suppressing or weight loss effects. The active compound P57 has poor oral bioavailability.

What dosage of hoodia has been studied in clinical trials?

The limited clinical research available used purified hoodia gordonii extract at doses ranging from 1,110 to 3,330 mg per day. A key Phase II clinical trial was discontinued due to concerns about liver function changes and lack of efficacy. No standardized dosing has been established.

What are the potential side effects of hoodia?

Reported side effects include nausea, vomiting, elevated blood pressure, elevated heart rate, and skin reactions. Liver function abnormalities were observed in clinical trials. Product authenticity is a significant concern, as many commercial hoodia products have been found to contain little or no actual hoodia.

Hoodia

herbal

Also known as: Hoodia gordonii, Bushman's Hat, Xhoba

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About

A succulent plant from the Kalahari Desert traditionally used by San people as an appetite suppressant. The only published RCT found no significant appetite reduction vs. placebo, and Unilever discontinued development due to lack of efficacy and safety concerns. Not recommended — included for consumer education.

How It Works

Contains the steroidal glycoside P57 (oxypregnane), which is theorized to act on the hypothalamus to mimic glucose sensing, signaling caloric sufficiency and suppressing appetite. The proposed mechanism involves increasing ATP content in hypothalamic neurons. However, bioavailability of P57 in humans is extremely poor, and the in vivo mechanism remains unverified.

Evidence For Conditions

Condition	Grade	Studies	Participants
Appetite Control	D	1	49	View →

Side Effects

Elevated liver enzymes
Elevated blood pressure
Elevated heart rate
Nausea
Skin reactions

Drug & Supplement Interactions

Diabetes medications (theoretical)
Hepatotoxic medications (additive liver risk)

Always inform your healthcare provider about all supplements you take.

Related Ingredients

Bitter Orange Extract Garcinia Cambogia Green Coffee Bean Extract Raspberry Ketones

Quick Facts

Dosage: General: No established effective dose; Marketed: 400-1,000 mg/day (no clinical basis)
Forms: capsule powder liquid
Natural Sources: Hoodia gordonii cactus (Kalahari Desert succulent; CITES-protected endangered species)
Upper Limit: Safety data insufficient; liver enzyme elevations observed in clinical trial
Best Time: Before meals (as marketed; no clinical basis)

Evidence Summary

Appetite Control D

FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.