Omega-3
vitamin_mineralAlso known as: EPA, DHA, Fish Oil, Eicosapentaenoic Acid, Docosahexaenoic Acid, Algal DHA
About
Essential fatty acids (EPA and DHA) that modulate adipose tissue inflammation and metabolic function. Systematic reviews of 44 RCTs demonstrate omega-3 supplementation may support healthy triglyceride levels and waist circumference, especially when combined with exercise.
How It Works
EPA and DHA modulate adipose tissue inflammation by replacing arachidonic acid in cell membranes, shifting eicosanoid production from pro-inflammatory (PGE2, LTB4) to anti-inflammatory mediators (resolvins, protectins). Activate PPAR-gamma in adipose tissue, improving insulin sensitivity. Enhance fat oxidation through AMPK activation and reduce lipogenesis via SREBP-1c suppression.
Evidence For Conditions
| Condition | Grade | Studies | Participants | |
|---|---|---|---|---|
| Metabolic Syndrome | B | 44 | 3000 | View → |
| Abdominal Fat Reduction | B | 21 | 1329 | View → |
| Cortisol-Related Weight Gain | C | 5 | 300 | View → |
Side Effects
- Fishy aftertaste
- GI discomfort
- Increased bleeding time (at high doses)
- Nausea
Drug & Supplement Interactions
- Blood thinners (may enhance anticoagulant effect at high doses)
- Blood pressure medications (additive effect)
- Orlistat (reduced absorption)
Always inform your healthcare provider about all supplements you take.
Related Ingredients
FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.