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Iron per Hypothyroid-Related Weight Gain

C Evidenze Evidenza limitata da studi di piccole dimensioni, ma esistono alcuni segnali positivi.

Iron is required for thyroid peroxidase (TPO), and iron deficiency impairs T4-to-T3 conversion and thyroid hormone synthesis. Meta-analysis of 22 RCTs found correction of iron deficiency improves exercise tolerance and VO2max. Supplement only when deficiency is confirmed.

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In sintesi

Iron is required for thyroid peroxidase (TPO), and iron deficiency impairs T4-to-T3 conversion and thyroid hormone synthesis. Meta-analysis of 22 RCTs found correction of iron deficiency improves exercise tolerance and VO2max. Supplement only when deficiency is confirmed.

Key Study Findings

Retrospective cohort n=2851
Retrospective Review of 2851 Female Patients With Telogen Effluvium: A Single-Center Experience.
Dose: None vs: Placebo Effetto: Ferritin low in 46.5% of patients; iron deficiency in 29.5% p<0.05
Review
Impact of Vitamin D on Immunopathology of Hashimoto's Thyroiditis: From Theory to Practice.
Dose: Vitamin D vs: None Outcome: Thyroid autoimmunity modulation Effetto: None None

Popolazione: Hashimoto's thyroiditis patients

Case-control n=100
The Association of Serum Ferritin Levels With Non-scarring Alopecia in Women.
Dose: None vs: Placebo Effetto: MD=-7.40 (20.47 vs 27.87 µg/dL) p=0.005
Review
Role of Dietary Supplements in Thyroid Diseases.
Dose: None vs: None Outcome: None Effetto: None None

Popolazione: Patients with thyroid diseases

Observational Study n=218
Retrospective evaluation of clinical profile and comorbidities in patients with alopecia areata.
Dose: None vs: AA patients without comorbidity Outcome: Clinical profile and comorbidities Effetto: None p=0.008

Popolazione: Patients with alopecia areata (mean age 27.8y)

Key Statistics

22

Studi

2000

Partecipanti

Positive

C

Grado

Referenced Papers

Endocrine, metabolic & … 2022 8 citazioni
Acta scientiarum polonorum. … 2021 7 citazioni
Thyroid : official … 2017 170 citazioni
Journal of the … 2005 247 citazioni

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Dosaggi di uso comune

general:
8-18 mg/day (RDA)
menstruatingwomen:
18 mg/day
deficiencycorrection:
100-200 mg elemental iron/day under medical guidance

Limite massimo: 45 mg/day (elemental iron); excess iron increases oxidative stress

Dosaggi studiati nella ricerca

Dosaggio Durata Effetto N
None -- Neutral 2851
not applicable -- Mixed 180
Vitamin D -- Positive --
None -- Negative 100
None -- Mixed --
None -- Mixed 218
None -- Positive --
standard replacement doses -- Neutral 3028

Momento migliore per l'assunzione: On empty stomach with vitamin C for absorption; avoid with calcium, coffee, tea

Safety & Side Effects

Effetti collaterali segnalati

  • Constipation
  • Nausea
  • Stomach pain
  • Black stools
  • Oxidative stress (excess iron)

Interazioni note

  • Levothyroxine (reduced absorption — take 4 hours apart)
  • Tetracycline antibiotics (reduced absorption)
  • Calcium supplements (reduced absorption)
  • Proton pump inhibitors (reduced absorption)

Livello di assunzione massimo tollerabile: 45 mg/day (elemental iron); excess iron increases oxidative stress

Consultare sempre il proprio medico prima di iniziare qualsiasi integratore.Consultate sempre il vostro medico prima di iniziare qualsiasi integratore.

Frequently Asked Questions

Does Iron help with Hypothyroid-Related Weight Gain?
Based on 22 studies with 2,000 participants, there is limited but promising evidence that Iron may support Hypothyroid-Related Weight Gain management. Our evidence grade is C (Some Evidence).
How much Iron should I take for Hypothyroid-Related Weight Gain?
Studies have used various dosages. A commonly studied range is 8-18 mg/day (RDA). Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Iron?
Reported side effects may include Constipation, Nausea, Stomach pain, Black stools. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Iron and Hypothyroid-Related Weight Gain?
We rate the evidence as Grade C (Some Evidence). This rating is based on 22 peer-reviewed studies with 2,000 total participants. The overall direction of effect is positive.

References

  1. [1] Ömer Karakoyun et al.. J Cosmet Dermatol. 2025. Retrospective Review of 2851 Female Patients With Telogen Effluvium: A Single-Center Experience. doi:10.1111/jocd.70037 PubMed
  2. [2] Irem Nur Durusu Turkoglu et al.. J Cosmet Dermatol. 2024. A comprehensive investigation of biochemical status in patients with telogen effluvium: Analysis of Hb, ferritin, vitamin B12, vitamin D, thyroid … doi:10.1111/jocd.16512 PubMed
  3. [3] Filip Lebiedziński et al.. Nutrients. 2023. Impact of Vitamin D on Immunopathology of Hashimoto's Thyroiditis: From Theory to Practice. doi:10.3390/nu15143174 PubMed
  4. [4] Aniceta A Mikulska et al.. Int J Mol Sci. 2022. Metabolic Characteristics of Hashimoto's Thyroiditis Patients and the Role of Microelements and Diet in the Disease Management-An Overview. doi:10.3390/ijms23126580 PubMed
  5. [5] Ahu Yorulmaz et al.. J Cosmet Dermatol. 2022. Telogen effluvium in daily practice: Patient characteristics, laboratory parameters, and treatment modalities of 3028 patients with telogen effluvium. doi:10.1111/jocd.14413 PubMed
  6. [6] Vinesh Dahiya et al.. Endocr Metab Immune Disord Drug Targets. 2022. Role of Dietary Supplements in Thyroid Diseases. doi:10.2174/1871530322666220419125131 PubMed
  7. [7] Sule Goksin. North Clin Istanb. 2022. Retrospective evaluation of clinical profile and comorbidities in patients with alopecia areata. doi:10.14744/nci.2022.78790 PubMed
  8. [8] Muhammad Fawad Aslam et al.. Cureus. 2022. The Association of Serum Ferritin Levels With Non-scarring Alopecia in Women. doi:10.7759/cureus.32123 PubMed
  9. [9] Zhe Han et al.. Front Immunol. 2021. The Potential Prebiotic Berberine Combined With Methimazole Improved the Therapeutic Effect of Graves' Disease Patients Through Regulating the Intestinal Microbiome. doi:10.3389/fimmu.2021.826067 PubMed
  10. [10] Dagmara Woźniak et al.. Acta Sci Pol Technol Aliment. 2021. Dietary supplements in hypothyroidism. doi:10.17306/J.AFS.0985 PubMed
  11. [11] Kavita Poonia et al.. J Cosmet Dermatol. 2019. NonScarring Diffuse Hair Loss in Women: a Clinico-Etiological Study from tertiary care center in North-West India. doi:10.1111/jocd.12559 PubMed
  12. [12] Karolina Kozicka et al.. Pol Merkur Lekarski. 2019. Methods of treatment patients with androgenetic alopecia based on reference of Department of Dermatology in Cracow. PubMed
  13. [13] Shiqian Hu et al.. Thyroid. 2017. Multiple Nutritional Factors and the Risk of Hashimoto's Thyroiditis. doi:10.1089/thy.2016.0635 PubMed
  14. [14] İrfan Ozer et al.. J Matern Fetal Neonatal Med. 2017. A prospective case control questionnaire study for restless leg syndrome on 600 pregnant women. doi:10.3109/14767058.2016.1170801 PubMed
  15. [15] Tee Wei Siah et al.. Int J Trichology. 2016. Female Pattern Hair Loss: A Retrospective Study in a Tertiary Referral Center. doi:10.4103/0974-7753.188033 PubMed
  16. [16] Kirti Deo et al.. Dermatol Res Pract. 2016. Clinicoepidemiological Observational Study of Acquired Alopecias in Females Correlating with Anemia and Thyroid Function. doi:10.1155/2016/6279108 PubMed
  17. [17] Elise A Olsen et al.. J Am Acad Dermatol. 2005. Evaluation and treatment of male and female pattern hair loss. doi:10.1016/j.jaad.2004.04.008 PubMed

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