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Vitamin B12
Vitamin B12

vitamin_mineral

Noto anche come: Cobalamin, Methylcobalamin, Cyanocobalamin, Hydroxocobalamin, Adenosylcobalamin

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About





            

                
An essential cofactor for fatty acid metabolism and red blood cell formation. B12 deficiency — which is common in metformin users (10-30%) and vegans — impairs mitochondrial fatty acid oxidation and causes fatigue that limits physical activity. Benefits for weight management are primarily seen when correcting deficiency.

            

        

        

        
        
        

            

  
How It Works





            

                
Essential cofactor for methionine synthase (homocysteine remethylation) and methylmalonyl-CoA mutase (fatty acid and amino acid metabolism). B12 deficiency impairs mitochondrial fatty acid oxidation, leading to abnormal lipid accumulation. Also required for proper red blood cell formation — deficiency causes megaloblastic anemia with profound fatigue, reducing physical activity. Metformin depletes B12 in 10-30% of users.

            

        

        

        
        
        

            

  
Evidence For Conditions





            

                

                    

                        
                            

                                Condizione
                                Grado
                                Studi
                                Partecipanti
                                
                            

                        
                        
                            
                            

                                
                                    
                                        Post-Bariatric Nutritional Support
                                    
                                
                                
                                    B

                                
                                
                                    10
                                
                                
                                    1000
                                
                                
                                    
                                        Visualizza →
                                    
                                
                            

                            
                            

                                
                                    
                                        Slow Metabolism
                                    
                                
                                
                                    C

                                
                                
                                    5
                                
                                
                                    9000
                                
                                
                                    
                                        Visualizza →
                                    
                                
                            

                            
                        
                    

                

            

        

        

        
        
        

            

  
Side Effects





            
    
                
                
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                    Acne (rare, at high doses)
                
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                    Diarrhea (rare)
                
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                    Generally very well tolerated
                
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Drug & Supplement Interactions





            
    
                
                
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                    Metformin (depletes B12 — monitor levels)
                
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                    Proton pump inhibitors (reduced absorption)
                
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                    H2 receptor antagonists (reduced absorption)
                
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                    Colchicine (reduced absorption)
                
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                Informare sempre il proprio medico di tutti gli integratori che si assumono.Informate sempre il vostro medico di tutti gli integratori che assumete.
            

        

        

        
        
        

            

  
Related Ingredients





            

                
                
                    B-Complex
                    
                
                
                
                    Iron
                    
                
                
                
                    Magnesium
                    
                
                
                
                    Zinc
                    
                
                
                
                    Omega-3
                    
                
                
            

        

        
    


    
    












    

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        Queste affermazioni non sono state valutate dalla Food and Drug Administration. I prodotti e le informazioni presenti su questo sito web non sono destinati a diagnosticare, trattare, curare o prevenire alcuna malattia. I gradi di evidenza presentati si basano sulla nostra analisi della ricerca pubblicata e sottoposta a revisione paritaria e non costituiscono consulenza medica. Consultate sempre il vostro medico prima di iniziare qualsiasi regime di integrazione.