What is the recommended dosage for CLA?

General: 3.2-6.4 g/day mixed isomers; Body Composition: 3.4 g/day (50:50 c9,t11:t10,c12 blend); Minimum Effective: 3.2 g/day for ≥12 weeks

What are the side effects of CLA?

Potential side effects include: GI discomfort, May worsen insulin sensitivity at high doses, Possible HDL reduction, Fatty liver (in some rodent studies).

What is CLA and how may it support weight management?

Conjugated linoleic acid (CLA) is a group of fatty acids found naturally in dairy and meat from ruminant animals. Some clinical trials suggest CLA supplementation may modestly reduce body fat mass, though effects on total body weight have been inconsistent across studies.

What dosage of CLA has been studied in clinical trials?

Most clinical trials have used 3.2–6.4 grams of CLA per day, with the majority using 3.4 grams daily. The active isomers studied are typically a 50:50 mixture of c9,t11 and t10,c12 CLA. Study durations ranged from 12 weeks to 2 years.

What are the potential side effects of CLA supplements?

Common side effects include gastrointestinal discomfort, nausea, and diarrhea. Some studies have raised concerns about CLA's potential effects on insulin sensitivity, inflammation, and liver fat accumulation, particularly with the t10,c12 isomer. Individuals with metabolic conditions should consult a healthcare provider.

CLA
CLA

fat_metabolism

다른 이름: Conjugated Linoleic Acid, Tonalin, Clarinol

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About

A group of naturally occurring fatty acid isomers found in ruminant animal products. Conjugated linoleic acid (CLA) modulates adipose tissue metabolism and may support favorable changes in body composition by reducing fat mass while preserving lean mass over long-term supplementation.

How It Works

A group of positional and geometric isomers of linoleic acid (primarily c9,t11 and t10,c12) that modulate adipose tissue metabolism. The t10,c12 isomer inhibits stearoyl-CoA desaturase and lipoprotein lipase, reducing fat storage. Also activates PPAR-gamma and AMPK, increasing fat oxidation in skeletal muscle while reducing adipocyte lipid accumulation.

Evidence For Conditions

건강 상태	등급	연구	참여자
Obesity	B	18	807	보기 →

Side Effects

GI discomfort
May worsen insulin sensitivity at high doses
Possible HDL reduction
Fatty liver (in some rodent studies)

Drug & Supplement Interactions

Diabetes medications (may affect insulin sensitivity)
Blood thinners (theoretical)

복용 중인 모든 건강기능식품에 대해 반드시 의료 전문가에게 알리십시오.

Related Ingredients

L-Carnitine MCT Oil Berberine Alpha-Lipoic Acid

핵심 정보

용량: General: 3.2-6.4 g/day mixed isomers; Body_Composition: 3.4 g/day (50:50 c9,t11:t10,c12 blend); Minimum_Effective: 3.2 g/day for ≥12 weeks
제형: softgel capsule liquid
천연 원료: Grass-fed beef, Lamb, Full-fat dairy, Butter, Cheese (ruminant animal products)
상한 섭취량: 6 g/day; higher doses may worsen insulin sensitivity
권장 복용 시간: With meals; divide dose across 2-3 meals

근거 요약

Obesity B

FDA 면책 조항: 이 내용은 미국 식품의약국(FDA)의 평가를 받지 않았습니다. 이 웹사이트의 제품 및 정보는 질병의 진단, 치료, 완치 또는 예방을 목적으로 하지 않습니다. 제시된 근거 등급은 발표된 동료 심사 연구에 대한 우리의 분석에 기반하며, 의학적 조언을 구성하지 않습니다. 건강기능식품 복용을 시작하기 전에 반드시 의료 전문가와 상담하십시오.