What is the recommended dosage for Synephrine?

General: 10-20 mg p-synephrine 1-3x/day; Pre Exercise: 50 mg 45 min before; Weight Management: 25-50 mg/day

What are the side effects of Synephrine?

Potential side effects include: Mild increase in heart rate (at high doses), Headache, GI discomfort.

What is synephrine and how may it support weight management?

Synephrine is an alkaloid found in bitter orange (Citrus aurantium) that acts on adrenergic receptors. Some studies suggest it may increase resting metabolic rate and fat oxidation. It became popular as an alternative after ephedra was banned by the FDA in 2004.

What dosage of synephrine has been studied in clinical trials?

Clinical trials have typically studied synephrine at 10–50 mg per day, often as p-synephrine from bitter orange extract. Most studies lasted 6–12 weeks. Higher doses have not been adequately studied for long-term safety.

What are the potential side effects of synephrine?

Synephrine may increase blood pressure and heart rate, especially when combined with caffeine. Adverse event reports include chest pain, tachycardia, and cardiovascular events, though causality is not always established. It should be avoided by individuals with heart conditions or hypertension.

Synephrine
Synephrine

thermogenic

Também conhecido como: p-Synephrine, Citrus aurantium Extract, Bitter Orange Extract

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About

A naturally occurring alkaloid from bitter orange peel that selectively activates beta-3 adrenergic receptors. Synephrine supports metabolic rate and fat oxidation without the significant cardiovascular stimulation associated with ephedrine-type compounds.

How It Works

Selective beta-3 adrenergic receptor agonist that stimulates lipolysis and thermogenesis without significantly activating beta-1 or beta-2 receptors (unlike ephedrine). Increases resting metabolic rate and fat oxidation while showing minimal cardiovascular stimulation at recommended doses.

Evidence For Conditions

Condição	Nota	Estudos	Participantes
Fat Oxidation Enhancement	B	20	1000	Ver →

Side Effects

Mild increase in heart rate (at high doses)
Headache
GI discomfort

Drug & Supplement Interactions

MAOIs
Other stimulants (avoid combination)
Caffeine (theoretical cardiovascular interaction)

Informe sempre o seu profissional de saúde sobre todos os suplementos que você toma.Sempre informe seu profissional de saúde sobre todos os suplementos que você toma.

Caffeine Capsaicin Forskolin Green Tea Extract (EGCG)

Dados Rápidos

Dosagem: General: 10-20 mg p-synephrine 1-3x/day; Pre_Exercise: 50 mg 45 min before; Weight_Management: 25-50 mg/day
Formas: capsule tablet extract
Fontes Naturais: Bitter orange (Citrus aurantium) peel
Limite Superior: 100 mg/day; avoid combination with other stimulants
Melhor Horário: 30-45 minutes before meals or exercise

Resumo das Evidências

Fat Oxidation Enhancement B

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Aviso Legal da FDA: Estas declarações não foram avaliadas pela Food and Drug Administration. Os produtos e informações neste site não se destinam a diagnosticar, tratar, curar ou prevenir qualquer doença. As notas de evidência apresentadas são baseadas em nossa análise de pesquisas revisadas por pares publicadas e não constituem aconselhamento médico. Sempre consulte seu profissional de saúde antes de iniciar qualquer regime de suplementação.