Alpha-Lipoic Acid لـ Obesity

B الأدلة تدعم ذلك تجربة عشوائية واحدة على الأقل، مع نتائج متسقة في معظمها.

Meta-analysis of 12 RCTs (n=534) found significant weight loss of 1.27 kg and BMI reduction of 0.43. A 20-week RCT (n=360) found 1,800 mg/day reduced body weight by 2.1%. Higher doses and longer durations showed greater effects.

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الخلاصة

Key Study Findings

Other

Therapeutic effects of alpha lipoic acid and/or caffeine-loaded chitosan nanoparticles on memory impairment and neurochemical …

Dose: None مقابل: None Outcome: Cognitive function التأثير: None None

المجتمع المدروس: Rat model

In Vitro

α-Lipoic acid attenuates obesity-associated hippocampal neuroinflammation and increases the levels of brain-derived neurotrophic factor in …

Dose: None مقابل: Ovariectomized rats on high-fat diet without alpha-LA Outcome: Hippocampal neuroinflammation and BDNF levels التأثير: None None

المجتمع المدروس: Ovariectomized rats fed high-fat diet

Key Statistics

الدراسات

534

المشاركون

↑

Positive

التقييم

Referenced Papers

Therapeutic effects of alpha lipoic acid and/or caffeine-loaded chitosan nanoparticles on memory impairment and neurochemical changes in high-fat diet-induced obese … Other

Physiology & behavior 2024 3 اقتباسات

α-Lipoic acid attenuates obesity-associated hippocampal neuroinflammation and increases the levels of brain-derived neurotrophic factor in ovariectomized rats fed a high-fat … Other

International journal of … 2013 29 اقتباسات

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

الجرعات الشائعة

general:: 300-600 mg/day
ralaactiveform:: 150-300 mg/day
weightmanagement:: 600-1,800 mg/day

الحد الأعلى: 1,800 mg/day; GI side effects at higher doses

الجرعات المدروسة في الأبحاث

الجرعة	المدة	التأثير	ن
None	--	Positive	--
None	--	Positive	--

أفضل وقت للتناول: 30 minutes before meals on empty stomach (food reduces absorption by ~30%)

Safety & Side Effects

الآثار الجانبية المُبلّغ عنها

⚠ Nausea
⚠ Skin rash
⚠ Hypoglycemia (when combined with diabetes medications)
⚠ GI discomfort

التفاعلات المعروفة

● Diabetes medications (may potentiate — hypoglycemia risk)
● Thyroid medications (may affect thyroid hormone levels)
● Chemotherapy agents (antioxidant interaction)

الحد الأقصى المسموح به: 1,800 mg/day; GI side effects at higher doses

استشر مقدم الرعاية الصحية دائماً قبل البدء بأي مكمل غذائي.

Frequently Asked Questions

Does Alpha-Lipoic Acid help with Obesity?

Based on 12 studies with 534 participants, there is moderate evidence from clinical studies that Alpha-Lipoic Acid may support Obesity management. Our evidence grade is B (Good Evidence).

How much Alpha-Lipoic Acid should I take for Obesity?

Studies have used various dosages. A commonly studied range is 300-600 mg/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Alpha-Lipoic Acid?

Reported side effects may include Nausea, Skin rash, Hypoglycemia (when combined with diabetes medications), GI discomfort. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Alpha-Lipoic Acid and Obesity?

We rate the evidence as Grade B (Good Evidence). This rating is based on 12 peer-reviewed studies with 534 total participants. The overall direction of effect is positive.

مكونات أخرى لـ Obesity

Glucomannan A CLA B Green Tea Extract (EGCG) B Vitamin D B Prebiotics/Inulin C Probiotics (Lactobacillus gasseri) C

Alpha-Lipoic Acid لحالات أخرى

Insulin Resistance B

الخلاصة السريعة

Meta-analysis of 12 RCTs (n=534) found significant weight loss of 1.27 kg and BMI reduction of 0.43. A 20-week RCT (n=360) found 1,800 mg/day reduced body weight by 2.1%. Higher …

Evidence Strength72%

High confidence

تفصيل الدراسات

RCT (0)Meta (0)Other (12)

قارن البدائل

اعرف كيف تقارن المكونات الأخرى لهذه الحالة.

عرض جميع المكونات لـ Obesity

اعرف المزيد

References

[1] Eman N Hosny et al.. Physiol Behav. 2024. Therapeutic effects of alpha lipoic acid and/or caffeine-loaded chitosan nanoparticles on memory impairment and neurochemical changes in high-fat diet-induced obese … doi:10.1016/j.physbeh.2024.114697 PubMed
[2] Yulian Miao et al.. Int J Mol Med. 2013. α-Lipoic acid attenuates obesity-associated hippocampal neuroinflammation and increases the levels of brain-derived neurotrophic factor in ovariectomized rats fed a high-fat … doi:10.3892/ijmm.2013.1482 PubMed

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