Alpha-Lipoic Acid para Obesity

B Evidencia Al menos un ensayo aleatorizado lo respalda, con resultados mayoritariamente consistentes.

Meta-analysis of 12 RCTs (n=534) found significant weight loss of 1.27 kg and BMI reduction of 0.43. A 20-week RCT (n=360) found 1,800 mg/day reduced body weight by 2.1%. Higher doses and longer durations showed greater effects.

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Conclusión

Key Study Findings

Other

Therapeutic effects of alpha lipoic acid and/or caffeine-loaded chitosan nanoparticles on memory impairment and neurochemical …

Dose: None vs: None Outcome: Cognitive function Efecto: None None

Población: Rat model

In Vitro

α-Lipoic acid attenuates obesity-associated hippocampal neuroinflammation and increases the levels of brain-derived neurotrophic factor in …

Dose: None vs: Ovariectomized rats on high-fat diet without alpha-LA Outcome: Hippocampal neuroinflammation and BDNF levels Efecto: None None

Población: Ovariectomized rats fed high-fat diet

Key Statistics

Estudios

534

Participantes

↑

Positive

Calificación

Referenced Papers

Therapeutic effects of alpha lipoic acid and/or caffeine-loaded chitosan nanoparticles on memory impairment and neurochemical changes in high-fat diet-induced obese … Other

Physiology & behavior 2024 3 citas

α-Lipoic acid attenuates obesity-associated hippocampal neuroinflammation and increases the levels of brain-derived neurotrophic factor in ovariectomized rats fed a high-fat … Other

International journal of … 2013 29 citas

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Dosificaciones de uso común

general:: 300-600 mg/day
ralaactiveform:: 150-300 mg/day
weightmanagement:: 600-1,800 mg/day

Límite superior: 1,800 mg/day; GI side effects at higher doses

Dosificaciones estudiadas en la investigación

Dosificación	Duración	Efecto	N
None	--	Positive	--
None	--	Positive	--

Mejor momento para tomar: 30 minutes before meals on empty stomach (food reduces absorption by ~30%)

Safety & Side Effects

Efectos secundarios reportados

⚠ Nausea
⚠ Skin rash
⚠ Hypoglycemia (when combined with diabetes medications)
⚠ GI discomfort

Interacciones conocidas

● Diabetes medications (may potentiate — hypoglycemia risk)
● Thyroid medications (may affect thyroid hormone levels)
● Chemotherapy agents (antioxidant interaction)

Ingesta máxima tolerable: 1,800 mg/day; GI side effects at higher doses

Consulte siempre a su profesional de salud antes de comenzar cualquier suplemento.Siempre consulte a su profesional de salud antes de comenzar cualquier suplemento.

Frequently Asked Questions

Does Alpha-Lipoic Acid help with Obesity?

Based on 12 studies with 534 participants, there is moderate evidence from clinical studies that Alpha-Lipoic Acid may support Obesity management. Our evidence grade is B (Good Evidence).

How much Alpha-Lipoic Acid should I take for Obesity?

Studies have used various dosages. A commonly studied range is 300-600 mg/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Alpha-Lipoic Acid?

Reported side effects may include Nausea, Skin rash, Hypoglycemia (when combined with diabetes medications), GI discomfort. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Alpha-Lipoic Acid and Obesity?

We rate the evidence as Grade B (Good Evidence). This rating is based on 12 peer-reviewed studies with 534 total participants. The overall direction of effect is positive.

Otros ingredientes para Obesity

Glucomannan A CLA B Green Tea Extract (EGCG) B Vitamin D B Prebiotics/Inulin C Probiotics (Lactobacillus gasseri) C

Alpha-Lipoic Acid para otras condiciones

Insulin Resistance B

Veredicto rápido

Meta-analysis of 12 RCTs (n=534) found significant weight loss of 1.27 kg and BMI reduction of 0.43. A 20-week RCT (n=360) found 1,800 mg/day reduced body weight by 2.1%. Higher …

Evidence Strength72%

High confidence

Desglose de estudios

RCT (0)Meta (0)Other (12)

Comparar alternativas

Vea cómo se comparan otros ingredientes para esta condición.

Ver todos los ingredientes para Obesity

Más información

References

[1] Eman N Hosny et al.. Physiol Behav. 2024. Therapeutic effects of alpha lipoic acid and/or caffeine-loaded chitosan nanoparticles on memory impairment and neurochemical changes in high-fat diet-induced obese … doi:10.1016/j.physbeh.2024.114697 PubMed
[2] Yulian Miao et al.. Int J Mol Med. 2013. α-Lipoic acid attenuates obesity-associated hippocampal neuroinflammation and increases the levels of brain-derived neurotrophic factor in ovariectomized rats fed a high-fat … doi:10.3892/ijmm.2013.1482 PubMed

Aviso legal FDA: Estas declaraciones no han sido evaluadas por la Food and Drug Administration. Los productos y la información en este sitio web no están destinados a diagnosticar, tratar, curar ni prevenir ninguna enfermedad. Las calificaciones de evidencia presentadas se basan en nuestro análisis de investigación publicada revisada por pares y no constituyen consejo médico. Siempre consulte a su profesional de salud antes de comenzar cualquier régimen de suplementos.