Skip to main content
WeightCited

Synephrine for Fat Oxidation Enhancement

B

Systematic review of 20 studies found p-synephrine at 25-100 mg/day increases resting metabolic rate by 65-183 kcal/day. It is a selective beta-3 agonist without significant cardiovascular stimulation. A 12-week RCT (n=70) found greater weight loss with synephrine plus hesperidin versus placebo.

<\/script>\n
`; }, get iframeSnippet() { const domain = 'weightcited.com'; const params = 'ingredient\u003Dsynephrine\u0026condition\u003Dfat\u002Doxidation'; return ``; }, get activeSnippet() { return this.method === 'script' ? this.scriptSnippet : this.iframeSnippet; }, copySnippet() { navigator.clipboard.writeText(this.activeSnippet).then(() => { this.copied = true; setTimeout(() => { this.copied = false; }, 2000); }); } }" @keydown.escape.window="open = false" @click.outside="open = false">

Embed This Widget

Style



      
      
    


    
    

      Widget powered by
      .
      Free, no account required.
    

  




    








    

        

            B

        

        

            
The Bottom Line

            
            
Systematic review of 20 studies found p-synephrine at 25-100 mg/day increases resting metabolic rate by 65-183 kcal/day. It is a selective beta-3 agonist without significant cardiovascular stimulation. A 12-week RCT (n=70) found greater weight loss with synephrine plus hesperidin versus placebo.

            
            
        

    











    
    

        
        

            

  
Key Statistics





            


    

        
20

        
Studies

    

    

        
1000

        
Participants

    

    

        
            
            ↑
            
        
        
Positive

    

    

        B

        
Grade

    




        


        
        

        
        
        

            

  
Dosage & Usage





            
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units


            
            

                
Commonly Used Dosages

                

                    
                    

                        
general:

                        
10-20 mg p-synephrine 1-3x/day

                    

                    
                    

                        
preexercise:

                        
50 mg 45 min before

                    

                    
                    

                        
weightmanagement:

                        
25-50 mg/day

                    

                    
                

                
                

                    Upper limit: 100 mg/day; avoid combination with other stimulants
                

                
            

            

            

            
            

                Best taken: 30-45 minutes before meals or exercise
            

            
        

        

        
        
        

            

  
Safety & Side Effects





            

                
                

                    
Reported Side Effects

                    
    
                        
                        
  • 
                            ⚠
                            Mild increase in heart rate (at high doses)
                        
    • 
                        
                        
  • 
                            ⚠
                            Headache
                        
    • 
                        
                        
  • 
                            ⚠
                            GI discomfort
                        
    • 
                        
                    

                

                

                
                

                    
Known Interactions

                    
    
                        
                        
  • 
                            ●
                            MAOIs
                        
    • 
                        
                        
  • 
                            ●
                            Other stimulants (avoid combination)
                        
    • 
                        
                        
  • 
                            ●
                            Caffeine (theoretical cardiovascular interaction)
                        
    • 
                        
                    

                

                

                
                

                    

                        Tolerable upper intake: 100 mg/day; avoid combination with other stimulants
                    

                

                
            

            

                Always consult your healthcare provider before starting any supplement.
            

        

        

        
        
        

            

  
Frequently Asked Questions





            




    
    

        
            Does Synephrine help with Fat Oxidation Enhancement?
            
        
        

            Based on 20 studies with 1,000 participants, there is moderate evidence from clinical studies that Synephrine may support Fat Oxidation Enhancement management. Our evidence grade is B (Good Evidence).
        

    

    
    

        
            How much Synephrine should I take for Fat Oxidation Enhancement?
            
        
        

            Studies have used various dosages. A commonly studied range is 10-20 mg p-synephrine 1-3x/day. Always consult your healthcare provider before starting any supplement regimen.
        

    

    
    

        
            Are there side effects of Synephrine?
            
        
        

            Reported side effects may include Mild increase in heart rate (at high doses), Headache, GI discomfort. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
        

    

    
    

        
            How strong is the evidence for Synephrine and Fat Oxidation Enhancement?
            
        
        

            We rate the evidence as Grade B (Good Evidence). This rating is based on 20 peer-reviewed studies with 1,000 total participants. The overall direction of effect is positive.
        

    

    




        

        

        
        
        

            

  
Related Evidence





            

                
                

                    
Other ingredients for Fat Oxidation Enhancement

                    

                        
                        
                            Caffeine
                            A

                        
                        
                        
                            L-Carnitine
                            B

                        
                        
                        
                            Capsaicin
                            B

                        
                        
                    

                

                

                
            

        

        

    


    
    












    

        FDA Disclaimer:
        These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.