Magnesium per Metabolic Syndrome

B Evidenze Almeno un trial randomizzato lo supporta, con risultati per lo più coerenti.

Meta-analysis of 32 RCTs (n=2,382) found significant reductions in BMI, waist circumference, fasting glucose, and CRP. Each 100 mg/day increase in magnesium intake was associated with 5% lower metabolic syndrome risk. Up to 68% of Americans fail to meet the RDA.

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In sintesi

Key Study Findings

Observational Study n=155

Intake of fiber and micronutrients in patients with IBS.

Dose: None vs: None Outcome: Fiber and micronutrient intake in IBS patients Effetto: 91% low fiber; 85.8% low vitamin D None

Popolazione: IBS patients (Rome IV), 83.9% women, median 42 years

Case Reports 13.0 weeks

A case report of Gitelman syndrome in children.

Dose: 3 g vs: None Outcome: pain reduction Effetto: None None

Popolazione: Hypokalemia

Review

Consequences of Disturbing Manganese Homeostasis.

Dose: Manganese (Mn) - exposure assessment vs: None Outcome: Mn toxicity mechanisms on CNS Effetto: None None

Popolazione: General (manganese exposure review)

Review

Metabolic Characteristics of Hashimoto's Thyroiditis Patients and the Role of Microelements and Diet in the …

Dose: None vs: None Outcome: Thyroid function and autoantibody levels Effetto: None None

Popolazione: Hashimoto thyroiditis patients

Other

[Nutrition in the prevention and healing of chronic wounds. Importance in improving the diabetic foot].

Dose: None vs: None Outcome: None Effetto: None None

Popolazione: chronic wounds and have been linked to delayed wound healing and dehiscence

Cohort Study n=1107

Prevalence and associated risk factors of periodic limb movement in sleep in two German population-based …

Dose: None vs: None Outcome: None Effetto: OR = 2.20 None

Popolazione: None

Key Statistics

Studi

2382

Partecipanti

↑

Positive

Grado

Referenced Papers

A Comprehensive Review of Nutritional Influences on the Serotonergic System. Review

Advances in nutrition … 2025 5 citazioni

Intake of fiber and micronutrients in patients with IBS. Other

Scandinavian journal of … 2025

Consequences of Disturbing Manganese Homeostasis. Review

International journal of … 2023 120 citazioni

A case report of Gitelman syndrome in children. Case Report

Medicine 2023

Metabolic Characteristics of Hashimoto's Thyroiditis Patients and the Role of Microelements and Diet in the Disease Management-An Overview. Review

International journal of … 2022 102 citazioni

[Nutrition in the prevention and healing of chronic wounds. Importance in improving the diabetic foot]. Other

Nutricion hospitalaria 2021 20 citazioni

Prevalence and associated risk factors of periodic limb movement in sleep in two German population-based studies. Other

Sleep 2019 38 citazioni

Evaluation of Dietary Intakes and Supplement Use in Paralympic Athletes. Other

Nutrients 2017 46 citazioni

[Restless legs syndrome and periodic limb movements during sleep in a patient with obstructive sleep apnea]. Other

Neurologia i neurochirurgia … 2004 2 citazioni

Magnesium, zinc, and chromium nutriture and physical activity. Review

The American journal … 2000 207 citazioni

Effects of spironolactone on serum and muscle electrolytes in patients on long-term diuretic therapy for congestive heart failure and/or arterial … RCT

European journal of … 1986 22 citazioni

Depression or asthenia related to metabolic disturbances in obese patients after intestinal bypass surgery. Other

Acta psychiatrica Scandinavica 1979 22 citazioni

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Dosaggi di uso comune

general:: 310-420 mg/day (RDA)
sleepsupport:: 200-400 mg glycinate before bed
weightmanagement:: 250-500 mg elemental magnesium/day

Limite massimo: 350 mg/day from supplements only (laxative effect); no UL from food sources

Dosaggi studiati nella ricerca

Dosaggio	Durata	Effetto	N
None	--	Negative	155
3 g	13.0 weeks	Mixed	--
Manganese (Mn) - exposure assessment	--	Negative	--
None	--	Positive	--
None	--	Positive	--
None	--	Mixed	1107
None	--	Mixed	40
None	--	Mixed	1

Momento migliore per l'assunzione: Evening (glycinate/threonate for sleep); with meals (citrate) to reduce GI effects

Safety & Side Effects

Effetti collaterali segnalati

⚠ Diarrhea (especially oxide form)
⚠ Nausea
⚠ Abdominal cramping
⚠ Low blood pressure (at very high doses)

Interazioni note

● Antibiotics (reduced absorption — take 2 hours apart)
● Bisphosphonates (reduced absorption)
● Diuretics (may increase or decrease levels)
● Proton pump inhibitors (may deplete magnesium)

Livello di assunzione massimo tollerabile: 350 mg/day from supplements only (laxative effect); no UL from food sources

Consultare sempre il proprio medico prima di iniziare qualsiasi integratore.Consultate sempre il vostro medico prima di iniziare qualsiasi integratore.

Frequently Asked Questions

Does Magnesium help with Metabolic Syndrome?

Based on 32 studies with 2,382 participants, there is moderate evidence from clinical studies that Magnesium may support Metabolic Syndrome management. Our evidence grade is B (Good Evidence).

How much Magnesium should I take for Metabolic Syndrome?

Studies have used various dosages. A commonly studied range is 310-420 mg/day (RDA). Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Magnesium?

Reported side effects may include Diarrhea (especially oxide form), Nausea, Abdominal cramping, Low blood pressure (at very high doses). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Magnesium and Metabolic Syndrome?

We rate the evidence as Grade B (Good Evidence). This rating is based on 32 peer-reviewed studies with 2,382 total participants. The overall direction of effect is positive.

Altri ingredienti per Metabolic Syndrome

Berberine A Omega-3 B Taurine B

Magnesium per altre condizioni

Insulin Resistance B

Verdetto rapido

Evidence Strength72%

High confidence

Analisi degli studi

RCT (1)Meta (0)Other (31)

Confronta le alternative

Scoprite come si confrontano altri ingredienti per questa condizione.

Visualizza tutti gli ingredienti per Metabolic Syndrome

Approfondimenti

References

[1] Justin Tang et al.. Adv Nutr. 2025. A Comprehensive Review of Nutritional Influences on the Serotonergic System. doi:10.1016/j.advnut.2025.100524 PubMed
[2] Bodil Roth et al.. Scand J Gastroenterol. 2025. Intake of fiber and micronutrients in patients with IBS. doi:10.1080/00365521.2025.2535721 PubMed
[3] Jacek Baj et al.. Int J Mol Sci. 2023. Consequences of Disturbing Manganese Homeostasis. doi:10.3390/ijms241914959 PubMed
[4] Jing Ying et al.. Medicine (Baltimore). 2023. A case report of Gitelman syndrome in children. doi:10.1097/MD.0000000000033509 PubMed
[5] Aniceta A Mikulska et al.. Int J Mol Sci. 2022. Metabolic Characteristics of Hashimoto's Thyroiditis Patients and the Role of Microelements and Diet in the Disease Management-An Overview. doi:10.3390/ijms23126580 PubMed
[6] Rosa María Martínez García et al.. Nutr Hosp. 2021. [Nutrition in the prevention and healing of chronic wounds. Importance in improving the diabetic foot]. doi:10.20960/nh.03800 PubMed
[7] András Szentkirályi et al.. Sleep. 2019. Prevalence and associated risk factors of periodic limb movement in sleep in two German population-based studies. doi:10.1093/sleep/zsy237 PubMed
[8] Robyn F Madden et al.. Nutrients. 2017. Evaluation of Dietary Intakes and Supplement Use in Paralympic Athletes. doi:10.3390/nu9111266 PubMed
[9] Luiza Jonczak et al.. Neurol Neurochir Pol. 2004. [Restless legs syndrome and periodic limb movements during sleep in a patient with obstructive sleep apnea]. PubMed
[10] H C Lukaski. Am J Clin Nutr. 2000. Magnesium, zinc, and chromium nutriture and physical activity. doi:10.1093/ajcn/72.2.585S PubMed
[11] T Dyckner et al.. Eur J Clin Pharmacol. 1986. Effects of spironolactone on serum and muscle electrolytes in patients on long-term diuretic therapy for congestive heart failure and/or arterial … doi:10.1007/BF00542411 PubMed
[12] P Bech et al.. Acta Psychiatr Scand. 1979. Depression or asthenia related to metabolic disturbances in obese patients after intestinal bypass surgery. doi:10.1111/j.1600-0447.1979.tb00245.x PubMed

Avvertenza FDA: Queste affermazioni non sono state valutate dalla Food and Drug Administration. I prodotti e le informazioni presenti su questo sito web non sono destinati a diagnosticare, trattare, curare o prevenire alcuna malattia. I gradi di evidenza presentati si basano sulla nostra analisi della ricerca pubblicata e sottoposta a revisione paritaria e non costituiscono consulenza medica. Consultate sempre il vostro medico prima di iniziare qualsiasi regime di integrazione.