What is the recommended dosage for Bitter Orange Extract?

General: 100-200 mg bitter orange extract/day (standardized to 6-10% synephrine); Synephrine Equivalent: 10-50 mg p-synephrine/day

What are the side effects of Bitter Orange Extract?

Potential side effects include: Increased heart rate (in combination products), Headache, GI discomfort.

What is bitter orange and how may it support weight management?

Bitter orange (Citrus aurantium) contains synephrine, an alkaloid that may stimulate metabolic rate. It has been marketed as a replacement for ephedra since the latter was banned. Clinical evidence for weight loss effects is limited, and safety concerns exist regarding cardiovascular effects.

What dosage of bitter orange has been studied in clinical trials?

Clinical studies have used bitter orange extracts providing 10–50 mg of synephrine per day. Whole bitter orange extracts have been used at 200–975 mg daily. Many studies combined bitter orange with caffeine and other ingredients, making it difficult to isolate its individual effects.

What are the potential side effects of bitter orange?

Bitter orange may increase blood pressure and heart rate. Adverse event reports include chest pain, anxiety, and cardiovascular events, particularly when combined with caffeine. It may interact with medications metabolized by CYP3A4 enzymes. Individuals with heart conditions should avoid this supplement.

Bitter Orange Extract
Bitter Orange Extract

herbal

Noto anche come: Citrus aurantium, Synephrine Source, Zhi Shi (TCM), Seville Orange

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About

A botanical extract from Citrus aurantium peel containing p-synephrine and flavonoids. Safety reviews of clinical studies have not identified significant adverse cardiovascular effects at standard doses, but FDA adverse event reports associated with multi-ingredient products limit conclusions about isolated efficacy.

How It Works

Contains p-synephrine (primary active), octopamine, and naringin. P-synephrine selectively activates beta-3 adrenergic receptors in adipose tissue, stimulating lipolysis and thermogenesis. Naringin and hesperidin (flavonoids) provide synergistic metabolic effects through AMPK activation and improved insulin sensitivity.

Side Effects

Increased heart rate (in combination products)
Headache
GI discomfort

Drug & Supplement Interactions

MAOIs
Caffeine and other stimulants (avoid combination)
CYP3A4 substrates (naringin inhibits CYP3A4)

Informare sempre il proprio medico di tutti gli integratori che si assumono.Informate sempre il vostro medico di tutti gli integratori che assumete.

Related Ingredients

Garcinia Cambogia Green Coffee Bean Extract Hoodia Raspberry Ketones

Informazioni rapide

Dosaggio: General: 100-200 mg bitter orange extract/day (standardized to 6-10% synephrine); Synephrine_Equivalent: 10-50 mg p-synephrine/day
Forme: capsule extract dried peel
Fonti naturali: Bitter orange (Seville orange) peel, used in marmalade and traditional Chinese medicine
Limite massimo: Avoid combination with caffeine or other stimulants; cardiovascular monitoring recommended
Momento migliore: 30-45 minutes before meals or exercise

Avvertenza FDA: Queste affermazioni non sono state valutate dalla Food and Drug Administration. I prodotti e le informazioni presenti su questo sito web non sono destinati a diagnosticare, trattare, curare o prevenire alcuna malattia. I gradi di evidenza presentati si basano sulla nostra analisi della ricerca pubblicata e sottoposta a revisione paritaria e non costituiscono consulenza medica. Consultate sempre il vostro medico prima di iniziare qualsiasi regime di integrazione.