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BCAAs ： Muscle Preservation During Weight Loss

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Systematic review of 36 studies found BCAA supplementation during caloric restriction preserved lean body mass better than restriction alone. Observational study (n=4,429) found inverse association between BCAA intake and obesity (OR 0.66). Benefits are most pronounced when total protein intake is inadequate.

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            B

        

        

            
結論

            
            
Systematic review of 36 studies found BCAA supplementation during caloric restriction preserved lean body mass better than restriction alone. Observational study (n=4,429) found inverse association between BCAA intake and obesity (OR 0.66). Benefits are most pronounced when total protein intake is inadequate.

            
            
        

    










    

  
Key Study Findings





    

        
        

            

                
                    In Vitro
                
                
                
                
            

            
                Berberine alleviates insulin resistance by reducing peripheral branched-chain amino acids.
            
            

                
                Dose: None
                
                
                vs: None
                
                
                Outcome: Gut microbiota composition
                
                
                効果: None
                
                
                None
                
            

            
            
対象集団: healthy subjects

            
        

        
    







    
    

        
        

            

  
Key Statistics





            


    

        
36

        
研究数

    

    

        
4000

        
参加者数

    

    

        
            
            ↑
            
        
        
Positive

    

    

        B

        
グレード

    




        


        
        
        

            

  
Referenced Papers





            

                
                

                    

                        
                            Berberine alleviates insulin resistance by reducing peripheral branched-chain amino acids.
                        
                        
                            
                                Other
                            
                            
                            
                        
                    

                    

                        American journal of …
                        2019
                        
                        117 件の引用
                        
                    

                

                
            

        

        

        
        
        

            

  
Dosage & Usage





            
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units


            
            

                
一般的な使用量

                

                    
                    

                        
general:

                        
5-10 g/day (2:1:1 leucine:isoleucine:valine)

                    

                    
                    

                        
preexercise:

                        
5-10 g

                    

                    
                    

                        
musclepreservation:

                        
10-20 g/day during caloric deficit

                    

                    
                

                
                

                    上限量： No established UL; 35 g/day used safely in clinical trials
                

                
            

            

            
            

                
研究で検討された用量

                

                    

                        
                            

                                用量
                                期間
                                効果
                                N
                            

                        
                        
                            
                            

                                None
                                --
                                
                                    
                                    Positive
                                    
                                
                                --
                            

                            
                        
                    

                

            

            

            
            

                推奨摂取タイミング： Pre- or intra-exercise; between meals during caloric restriction
            

            
        

        

        
        
        

            

  
Safety & Side Effects





            

                
                

                    
報告されている副作用

                    
    
                        
                        
  • 
                            ⚠
                            Nausea (at high doses)
                        
    • 
                        
                        
  • 
                            ⚠
                            GI discomfort
                        
    • 
                        
                        
  • 
                            ⚠
                            Fatigue (very high doses)
                        
    • 
                        
                    

                

                

                
                

                    
既知の相互作用

                    
    
                        
                        
  • 
                            ●
                            Diabetes medications (may affect blood sugar)
                        
    • 
                        
                        
  • 
                            ●
                            Levodopa (competition for absorption)
                        
    • 
                        
                        
  • 
                            ●
                            Diazoxide
                        
    • 
                        
                    

                

                

                
                

                    

                        耐容上限摂取量： No established UL; 35 g/day used safely in clinical trials
                    

                

                
            

            

                サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。
            

        

        

        
        
        

            

  
Frequently Asked Questions





            




    
    

        
            Does BCAAs help with Muscle Preservation During Weight Loss?
            
        
        

            Based on 36 studies with 4,000 participants, there is moderate evidence from clinical studies that BCAAs may support Muscle Preservation During Weight Loss management. Our evidence grade is B (Good Evidence).
        

    

    
    

        
            How much BCAAs should I take for Muscle Preservation During Weight Loss?
            
        
        

            Studies have used various dosages. A commonly studied range is 5-10 g/day (2:1:1 leucine:isoleucine:valine). Always consult your healthcare provider before starting any supplement regimen.
        

    

    
    

        
            Are there side effects of BCAAs?
            
        
        

            Reported side effects may include Nausea (at high doses), GI discomfort, Fatigue (very high doses). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
        

    

    
    

        
            How strong is the evidence for BCAAs and Muscle Preservation During Weight Loss?
            
        
        

            We rate the evidence as Grade B (Good Evidence). This rating is based on 36 peer-reviewed studies with 4,000 total participants. The overall direction of effect is positive.
        

    

    




        

        

        
        
        

            

  




            

                
                

                    
に関する他の成分： Muscle Preservation During Weight Loss

                    

                        
                        
                            Whey Protein
                            A

                        
                        
                    

                

                

                
            

        

        

    


    
    






  
References

  
    
    
    
  1. 
      [1]
      Shi-Jun Yue et al..
      Am J Physiol Endocrinol Metab.
      2019.
      Berberine alleviates insulin resistance by reducing peripheral branched-chain amino acids.
      doi:10.1152/ajpendo.00256.2018
      PubMed
    
    2. 
    
  















    

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