Berberine ： Metabolic Syndrome

A エビデンス複数の大規模臨床試験が一貫して有意な効果を示しています。

Meta-analysis of 12 RCTs (n=1,068) found significant reductions in body weight (2.07 kg), BMI, waist circumference, and triglycerides. Berberine addresses multiple metabolic syndrome components simultaneously through AMPK activation.

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結論

Key Study Findings

Other 6 weeks

Berberine alleviates metabolic dysfunction-associated steatohepatitis by enhancing the abundance of Akkermansia muciniphila.

Dose: None vs: MCD diet MASH model; Abx + FMT experiments Outcome: Hepatic/colonic inflammation, Akkermansia abundance 効果: None None

対象集団: MCD diet-induced MASH C57BL/6J male mice

Other

The combination of berberine and evodiamine ameliorates high-fat diet-induced non-alcoholic fatty liver disease associated with …

Dose: None vs: None Outcome: None 効果: None None

対象集団: None

Systematic Review n=61

Berberine for prevention of dementia associated with diabetes and its comorbidities: A systematic review.

Dose: None vs: None Outcome: None 効果: None None

対象集団: Alzheimer's disease patients

Key Statistics

研究数

1068

参加者数

↑

Positive

グレード

Referenced Papers

Berberine alleviates metabolic dysfunction-associated steatohepatitis by enhancing the abundance of Akkermansia muciniphila. Other

The Journal of … 2025 1 件の引用

The combination of berberine and evodiamine ameliorates high-fat diet-induced non-alcoholic fatty liver disease associated with modulation of gut microbiota in … Other

Brazilian journal of … 2022 12 件の引用

Berberine for prevention of dementia associated with diabetes and its comorbidities: A systematic review. Systematic Review

Journal of integrative … 2020 33 件の引用

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

一般的な使用量

general:: 500 mg 2-3x/day with meals
starting:: 500 mg/day and titrate
metabolicsupport:: 1,000-1,500 mg/day

上限量： 1,500 mg/day; GI side effects limit intake; potential drug interactions

研究で検討された用量

用量	期間	効果	N
None	6 weeks	Positive	--
None	--	Mixed	--
None	--	Positive	61

推奨摂取タイミング： With meals (reduces GI discomfort and synchronizes with postprandial glucose metabolism)

Safety & Side Effects

報告されている副作用

⚠ Diarrhea
⚠ Constipation
⚠ Flatulence
⚠ Abdominal pain
⚠ Potential hypoglycemia (when combined with diabetes medications)

既知の相互作用

● Diabetes medications (may potentiate — hypoglycemia risk)
● CYP3A4 substrates (berberine is a CYP3A4 inhibitor)
● CYP2D6 substrates
● Cyclosporine
● Metformin (additive effects)

耐容上限摂取量： 1,500 mg/day; GI side effects limit intake; potential drug interactions

サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。

Frequently Asked Questions

Does Berberine help with Metabolic Syndrome?

Based on 12 studies with 1,068 participants, there is strong evidence from multiple clinical trials that Berberine may support Metabolic Syndrome management. Our evidence grade is A (Strong Evidence).

How much Berberine should I take for Metabolic Syndrome?

Studies have used various dosages. A commonly studied range is 500 mg 2-3x/day with meals. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Berberine?

Reported side effects may include Diarrhea, Constipation, Flatulence, Abdominal pain. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Berberine and Metabolic Syndrome?

We rate the evidence as Grade A (Strong Evidence). This rating is based on 12 peer-reviewed studies with 1,068 total participants. The overall direction of effect is positive.

に関する他の成分： Metabolic Syndrome

Omega-3 B Magnesium B Taurine B

Berberine 他の症状・状態について

Insulin Resistance A PCOS-Related Weight Management C

総合評価

Evidence Strength92%

High confidence

研究の内訳

RCT (0)Meta (0)Other (12)

代替成分との比較

この症状に対する他の成分との比較をご覧ください。

に関するすべての成分を見る： Metabolic Syndrome

詳しく見る

References

[1] Jiahui Xu et al.. J Nutr Biochem. 2025. Berberine alleviates metabolic dysfunction-associated steatohepatitis by enhancing the abundance of Akkermansia muciniphila. doi:10.1016/j.jnutbio.2025.110069 PubMed
[2] Yufan Dai et al.. Braz J Med Biol Res. 2022. The combination of berberine and evodiamine ameliorates high-fat diet-induced non-alcoholic fatty liver disease associated with modulation of gut microbiota in … doi:10.1590/1414-431X2022e12096 PubMed
[3] Noriko Shinjyo et al.. J Integr Med. 2020. Berberine for prevention of dementia associated with diabetes and its comorbidities: A systematic review. doi:10.1016/j.joim.2020.01.004 PubMed

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