The interaction between obesity and visceral hypersensitivity.

Wu Yanping, Xuefen Gao, Yizun Cheng, Mi Liu, Siyu Liao et al.

Review Journal of gastroenterology and hepatology 2023 16 citations

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Study Design

Study Type: Review
Population: None

Intervention: The interaction between obesity and visceral hypersensitivity. None
Comparator: None
Primary Outcome: inflammation markers
Effect Direction: Mixed
Risk of Bias: Unclear

Abstract

Obesity has been a worldwide problem associated with numerous chronic diseases such as cardiovascular disease, type 2 diabetes, and metabolic disorders. It may also play a role in visceral hypersensitivity, contributing to irritable bowel syndrome. (i) Adipose tissue secretes various inflammatory mediators, causing intestinal hyperpermeability and nerve endings activation. (ii) Obesity and gastrointestinal microbiota could affect each other, and microbial metabolites can increase sensitivity of the colon. (iii) Vitamin D deficiency contributes to both fat accumulation and disruption of the intestinal mucosal barrier. (iv) Brain-gut axis may be another bridge from obesity to visceral hypersensitivity.

TL;DR

This work has suggested that brain‐gut axis may be another bridge from obesity to visceral hypersensitivity, and obesity and gastrointestinal microbiota could affect each other, and microbial metabolites can increase sensitivity of the colon.

Used In Evidence Reviews

B Vitamin D for Obesity

The interaction between obesity and visceral hypersensitivity.

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Study Design

Abstract

TL;DR

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