Alpha-Lipoic Acid para Obesity

B Evidências Pelo menos um ensaio aleatorizado apoia esta conclusão, com resultados maioritariamente consistentes.

Meta-analysis of 12 RCTs (n=534) found significant weight loss of 1.27 kg and BMI reduction of 0.43. A 20-week RCT (n=360) found 1,800 mg/day reduced body weight by 2.1%. Higher doses and longer durations showed greater effects.

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Conclusão

Key Study Findings

Other

Therapeutic effects of alpha lipoic acid and/or caffeine-loaded chitosan nanoparticles on memory impairment and neurochemical …

Dose: None vs: None Outcome: Cognitive function Efeito: None None

População: Rat model

In Vitro

α-Lipoic acid attenuates obesity-associated hippocampal neuroinflammation and increases the levels of brain-derived neurotrophic factor in …

Dose: None vs: Ovariectomized rats on high-fat diet without alpha-LA Outcome: Hippocampal neuroinflammation and BDNF levels Efeito: None None

População: Ovariectomized rats fed high-fat diet

Key Statistics

Estudos

534

Participantes

↑

Positive

Nota

Referenced Papers

Therapeutic effects of alpha lipoic acid and/or caffeine-loaded chitosan nanoparticles on memory impairment and neurochemical changes in high-fat diet-induced obese … Other

Physiology & behavior 2024 3 citações

α-Lipoic acid attenuates obesity-associated hippocampal neuroinflammation and increases the levels of brain-derived neurotrophic factor in ovariectomized rats fed a high-fat … Other

International journal of … 2013 29 citações

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Dosagens Comumente Utilizadas

general:: 300-600 mg/day
ralaactiveform:: 150-300 mg/day
weightmanagement:: 600-1,800 mg/day

Limite superior: 1,800 mg/day; GI side effects at higher doses

Dosagens Estudadas em Pesquisas

Dosagem	Duração	Efeito	N
None	--	Positive	--
None	--	Positive	--

Melhor horário: 30 minutes before meals on empty stomach (food reduces absorption by ~30%)

Safety & Side Effects

Efeitos Colaterais Relatados

⚠ Nausea
⚠ Skin rash
⚠ Hypoglycemia (when combined with diabetes medications)
⚠ GI discomfort

Interações Conhecidas

● Diabetes medications (may potentiate — hypoglycemia risk)
● Thyroid medications (may affect thyroid hormone levels)
● Chemotherapy agents (antioxidant interaction)

Ingestão máxima tolerável: 1,800 mg/day; GI side effects at higher doses

Consulte sempre o seu profissional de saúde antes de iniciar qualquer suplemento.Sempre consulte seu profissional de saúde antes de iniciar qualquer suplemento.

Frequently Asked Questions

Does Alpha-Lipoic Acid help with Obesity?

Based on 12 studies with 534 participants, there is moderate evidence from clinical studies that Alpha-Lipoic Acid may support Obesity management. Our evidence grade is B (Good Evidence).

How much Alpha-Lipoic Acid should I take for Obesity?

Studies have used various dosages. A commonly studied range is 300-600 mg/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Alpha-Lipoic Acid?

Reported side effects may include Nausea, Skin rash, Hypoglycemia (when combined with diabetes medications), GI discomfort. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Alpha-Lipoic Acid and Obesity?

We rate the evidence as Grade B (Good Evidence). This rating is based on 12 peer-reviewed studies with 534 total participants. The overall direction of effect is positive.

Outros ingredientes para Obesity

Glucomannan A CLA B Green Tea Extract (EGCG) B Vitamin D B Prebiotics/Inulin C Probiotics (Lactobacillus gasseri) C

Alpha-Lipoic Acid para outras condições

Insulin Resistance B

Veredito Rápido

Meta-analysis of 12 RCTs (n=534) found significant weight loss of 1.27 kg and BMI reduction of 0.43. A 20-week RCT (n=360) found 1,800 mg/day reduced body weight by 2.1%. Higher …

Evidence Strength72%

High confidence

Detalhamento dos Estudos

RCT (0)Meta (0)Other (12)

Comparar Alternativas

Veja como outros ingredientes se comparam para esta condição.

Ver todos os ingredientes para Obesity

Saiba Mais

References

[1] Eman N Hosny et al.. Physiol Behav. 2024. Therapeutic effects of alpha lipoic acid and/or caffeine-loaded chitosan nanoparticles on memory impairment and neurochemical changes in high-fat diet-induced obese … doi:10.1016/j.physbeh.2024.114697 PubMed
[2] Yulian Miao et al.. Int J Mol Med. 2013. α-Lipoic acid attenuates obesity-associated hippocampal neuroinflammation and increases the levels of brain-derived neurotrophic factor in ovariectomized rats fed a high-fat … doi:10.3892/ijmm.2013.1482 PubMed

Aviso Legal da FDA: Estas declarações não foram avaliadas pela Food and Drug Administration. Os produtos e informações neste site não se destinam a diagnosticar, tratar, curar ou prevenir qualquer doença. As notas de evidência apresentadas são baseadas em nossa análise de pesquisas revisadas por pares publicadas e não constituem aconselhamento médico. Sempre consulte seu profissional de saúde antes de iniciar qualquer regime de suplementação.