What is the recommended dosage for Vitamin B12?

Vegans: 250-1,000 mcg/day; General: 2.4 mcg/day (RDA); Metformin Users: 1,000 mcg/day; Supplementation: 500-1,000 mcg/day methylcobalamin

What are the side effects of Vitamin B12?

Potential side effects include: Acne (rare, at high doses), Diarrhea (rare), Generally very well tolerated.

What is vitamin B12 and how may it relate to weight management?

Vitamin B12 (cobalamin) is essential for red blood cell formation, neurological function, and energy metabolism. B12 deficiency causes fatigue and weakness, which may impair exercise capacity. While B12 injections are marketed for weight loss, there is no strong clinical evidence that B12 supplementation promotes weight loss in non-deficient individuals.

What dosage of vitamin B12 is typically used in supplementation?

The RDA for vitamin B12 is 2.4 mcg per day for adults. Supplements commonly contain 500–5,000 mcg. Individuals at risk of deficiency include those over 50, vegans, vegetarians, and people with pernicious anemia or malabsorption. Both oral and sublingual forms are available; injections are used for severe deficiency.

What are the potential side effects of vitamin B12 supplements?

Oral vitamin B12 is generally very well tolerated, even at high doses, as excess is excreted in urine. Rare side effects include skin reactions and mild diarrhea. Injectable B12 may rarely cause injection site reactions. There is no established tolerable upper intake level for B12 due to its low toxicity potential.

Vitamin B12
Vitamin B12

vitamin_mineral

Также известен как: Cobalamin, Methylcobalamin, Cyanocobalamin, Hydroxocobalamin, Adenosylcobalamin

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About

An essential cofactor for fatty acid metabolism and red blood cell formation. B12 deficiency — which is common in metformin users (10-30%) and vegans — impairs mitochondrial fatty acid oxidation and causes fatigue that limits physical activity. Benefits for weight management are primarily seen when correcting deficiency.

How It Works

Essential cofactor for methionine synthase (homocysteine remethylation) and methylmalonyl-CoA mutase (fatty acid and amino acid metabolism). B12 deficiency impairs mitochondrial fatty acid oxidation, leading to abnormal lipid accumulation. Also required for proper red blood cell formation — deficiency causes megaloblastic anemia with profound fatigue, reducing physical activity. Metformin depletes B12 in 10-30% of users.

Evidence For Conditions

Состояние	Оценка	Исследования	Участники
Post-Bariatric Nutritional Support	B	10	1000	Подробнее →
Slow Metabolism	C	5	9000	Подробнее →

Side Effects

Acne (rare, at high doses)
Diarrhea (rare)
Generally very well tolerated

Drug & Supplement Interactions

Metformin (depletes B12 — monitor levels)
Proton pump inhibitors (reduced absorption)
H2 receptor antagonists (reduced absorption)
Colchicine (reduced absorption)

Всегда сообщайте лечащему врачу обо всех принимаемых добавках.

Related Ingredients

B-Complex Iron Magnesium Zinc Omega-3

Основные факты

Дозировка: Vegans: 250-1,000 mcg/day; General: 2.4 mcg/day (RDA); Metformin_Users: 1,000 mcg/day; Supplementation: 500-1,000 mcg/day methylcobalamin
Формы выпуска: sublingual tablet capsule liquid injection (medical) nasal spray
Природные источники: Liver, Clams, Sardines, Beef, Tuna, Fortified nutritional yeast, Fortified cereals
Верхний предел: No established UL (water-soluble, excess excreted)
Лучшее время приёма: Morning (may provide energy boost); sublingual for better absorption; separate from vitamin C (

Обзор доказательной базы

Post-Bariatric Nutritional Support B

Slow Metabolism C

Отказ от ответственности FDA: Данные утверждения не были оценены Управлением по санитарному надзору за качеством пищевых продуктов и медикаментов (FDA). Продукты и информация на этом сайте не предназначены для диагностики, лечения, излечения или профилактики каких-либо заболеваний. Представленные оценки доказательности основаны на нашем анализе опубликованных рецензируемых исследований и не являются медицинской консультацией. Всегда консультируйтесь с лечащим врачом перед началом приёма любых добавок.