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WeightCited

Caffeine
Caffeine

thermogenic

别名: 1,3,7-Trimethylxanthine, Caffeine Anhydrous, Guarana (caffeine source)

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About

A naturally occurring xanthine alkaloid and the world's most widely consumed psychoactive substance. Caffeine supports metabolic rate and fat oxidation through sympathetic nervous system activation. Extensively studied in clinical trials for its role in energy expenditure and exercise performance.

How It Works

Adenosine receptor antagonist that stimulates the sympathetic nervous system, increasing catecholamine release (epinephrine, norepinephrine). This activates hormone-sensitive lipase, mobilizing fatty acids from adipose tissue, and increases resting metabolic rate by 3-11%.

Evidence For Conditions

Side Effects

  • Insomnia
  • Anxiety and jitteriness
  • Increased heart rate
  • Digestive upset
  • Tolerance development over 1-2 weeks

Drug & Supplement Interactions

  • Adenosine receptor agonists
  • Lithium (reduced clearance)
  • Theophylline
  • MAOIs
  • Other stimulants (additive effects)

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Related Ingredients

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