CaffeineCaffeine
thermogenic
别名: 1,3,7-Trimethylxanthine, Caffeine Anhydrous, Guarana (caffeine source)
About
A naturally occurring xanthine alkaloid and the world's most widely consumed psychoactive substance. Caffeine supports metabolic rate and fat oxidation through sympathetic nervous system activation. Extensively studied in clinical trials for its role in energy expenditure and exercise performance.
How It Works
Adenosine receptor antagonist that stimulates the sympathetic nervous system, increasing catecholamine release (epinephrine, norepinephrine). This activates hormone-sensitive lipase, mobilizing fatty acids from adipose tissue, and increases resting metabolic rate by 3-11%.
Evidence For Conditions
| 健康状况 | 等级 | 研究数量 | 受试者 | |
|---|---|---|---|---|
| Exercise Performance for Weight Loss | A | 40 | 5000 | 查看 → |
| Fat Oxidation Enhancement | A | 13 | 606 | 查看 → |
| Weight Loss Plateau | C | 8 | 400 | 查看 → |
Side Effects
- Insomnia
- Anxiety and jitteriness
- Increased heart rate
- Digestive upset
- Tolerance development over 1-2 weeks
Drug & Supplement Interactions
- Adenosine receptor agonists
- Lithium (reduced clearance)
- Theophylline
- MAOIs
- Other stimulants (additive effects)
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Related Ingredients
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