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Vitamin B12
Vitamin B12

vitamin_mineral

别名: Cobalamin, Methylcobalamin, Cyanocobalamin, Hydroxocobalamin, Adenosylcobalamin

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About





            

                
An essential cofactor for fatty acid metabolism and red blood cell formation. B12 deficiency — which is common in metformin users (10-30%) and vegans — impairs mitochondrial fatty acid oxidation and causes fatigue that limits physical activity. Benefits for weight management are primarily seen when correcting deficiency.

            

        

        

        
        
        

            

  
How It Works





            

                
Essential cofactor for methionine synthase (homocysteine remethylation) and methylmalonyl-CoA mutase (fatty acid and amino acid metabolism). B12 deficiency impairs mitochondrial fatty acid oxidation, leading to abnormal lipid accumulation. Also required for proper red blood cell formation — deficiency causes megaloblastic anemia with profound fatigue, reducing physical activity. Metformin depletes B12 in 10-30% of users.

            

        

        

        
        
        

            

  
Evidence For Conditions





            

                

                    

                        
                            

                                健康状况
                                等级
                                研究数量
                                受试者
                                
                            

                        
                        
                            
                            

                                
                                    
                                        Post-Bariatric Nutritional Support
                                    
                                
                                
                                    B

                                
                                
                                    10
                                
                                
                                    1000
                                
                                
                                    
                                        查看 →
                                    
                                
                            

                            
                            

                                
                                    
                                        Slow Metabolism
                                    
                                
                                
                                    C

                                
                                
                                    5
                                
                                
                                    9000
                                
                                
                                    
                                        查看 →
                                    
                                
                            

                            
                        
                    

                

            

        

        

        
        
        

            

  
Side Effects





            
    
                
                
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                    Acne (rare, at high doses)
                
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                    Diarrhea (rare)
                
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                    Generally very well tolerated
                
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Drug & Supplement Interactions





            
    
                
                
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                    Metformin (depletes B12 — monitor levels)
                
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                    Proton pump inhibitors (reduced absorption)
                
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                    H2 receptor antagonists (reduced absorption)
                
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                    Colchicine (reduced absorption)
                
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                请务必告知您的医疗保健提供者您正在服用的所有补充剂。
            

        

        

        
        
        

            

  
Related Ingredients





            

                
                
                    B-Complex
                    
                
                
                
                    Iron
                    
                
                
                
                    Magnesium
                    
                
                
                
                    Zinc
                    
                
                
                
                    Omega-3
                    
                
                
            

        

        
    


    
    












    

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