Alpha-Lipoic Acid für Obesity

B Evidenz Mindestens eine randomisierte Studie unterstützt dies, mit überwiegend konsistenten Ergebnissen.

Meta-analysis of 12 RCTs (n=534) found significant weight loss of 1.27 kg and BMI reduction of 0.43. A 20-week RCT (n=360) found 1,800 mg/day reduced body weight by 2.1%. Higher doses and longer durations showed greater effects.

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Fazit

Key Study Findings

Other

Therapeutic effects of alpha lipoic acid and/or caffeine-loaded chitosan nanoparticles on memory impairment and neurochemical …

Dose: None vs.: None Outcome: Cognitive function Wirkung: None None

Population: Rat model

In Vitro

α-Lipoic acid attenuates obesity-associated hippocampal neuroinflammation and increases the levels of brain-derived neurotrophic factor in …

Dose: None vs.: Ovariectomized rats on high-fat diet without alpha-LA Outcome: Hippocampal neuroinflammation and BDNF levels Wirkung: None None

Population: Ovariectomized rats fed high-fat diet

Key Statistics

Studien

534

Teilnehmer

↑

Positive

Bewertung

Referenced Papers

Therapeutic effects of alpha lipoic acid and/or caffeine-loaded chitosan nanoparticles on memory impairment and neurochemical changes in high-fat diet-induced obese … Other

Physiology & behavior 2024 3 Zitierungen

α-Lipoic acid attenuates obesity-associated hippocampal neuroinflammation and increases the levels of brain-derived neurotrophic factor in ovariectomized rats fed a high-fat … Other

International journal of … 2013 29 Zitierungen

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Übliche Dosierungen

general:: 300-600 mg/day
ralaactiveform:: 150-300 mg/day
weightmanagement:: 600-1,800 mg/day

Obergrenze: 1,800 mg/day; GI side effects at higher doses

In der Forschung untersuchte Dosierungen

Dosierung	Dauer	Wirkung	N
None	--	Positive	--
None	--	Positive	--

Beste Einnahmezeit: 30 minutes before meals on empty stomach (food reduces absorption by ~30%)

Safety & Side Effects

Gemeldete Nebenwirkungen

⚠ Nausea
⚠ Skin rash
⚠ Hypoglycemia (when combined with diabetes medications)
⚠ GI discomfort

Bekannte Wechselwirkungen

● Diabetes medications (may potentiate — hypoglycemia risk)
● Thyroid medications (may affect thyroid hormone levels)
● Chemotherapy agents (antioxidant interaction)

Tolerierbare Höchstaufnahmemenge: 1,800 mg/day; GI side effects at higher doses

Konsultieren Sie immer Ihren Arzt, bevor Sie ein Nahrungsergänzungsmittel einnehmen.Konsultieren Sie immer Ihren Arzt, bevor Sie ein Nahrungsergänzungsmittel einnehmen.

Frequently Asked Questions

Does Alpha-Lipoic Acid help with Obesity?

Based on 12 studies with 534 participants, there is moderate evidence from clinical studies that Alpha-Lipoic Acid may support Obesity management. Our evidence grade is B (Good Evidence).

How much Alpha-Lipoic Acid should I take for Obesity?

Studies have used various dosages. A commonly studied range is 300-600 mg/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Alpha-Lipoic Acid?

Reported side effects may include Nausea, Skin rash, Hypoglycemia (when combined with diabetes medications), GI discomfort. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Alpha-Lipoic Acid and Obesity?

We rate the evidence as Grade B (Good Evidence). This rating is based on 12 peer-reviewed studies with 534 total participants. The overall direction of effect is positive.

Andere Inhaltsstoffe für Obesity

Glucomannan A CLA B Green Tea Extract (EGCG) B Vitamin D B Prebiotics/Inulin C Probiotics (Lactobacillus gasseri) C

Alpha-Lipoic Acid für andere Beschwerden

Insulin Resistance B

Kurzfazit

Meta-analysis of 12 RCTs (n=534) found significant weight loss of 1.27 kg and BMI reduction of 0.43. A 20-week RCT (n=360) found 1,800 mg/day reduced body weight by 2.1%. Higher …

Evidence Strength72%

High confidence

Studienübersicht

RCT (0)Meta (0)Other (12)

Alternativen vergleichen

Sehen Sie, wie andere Inhaltsstoffe bei dieser Beschwerde abschneiden.

Alle Inhaltsstoffe ansehen für Obesity

Mehr erfahren

References

[1] Eman N Hosny et al.. Physiol Behav. 2024. Therapeutic effects of alpha lipoic acid and/or caffeine-loaded chitosan nanoparticles on memory impairment and neurochemical changes in high-fat diet-induced obese … doi:10.1016/j.physbeh.2024.114697 PubMed
[2] Yulian Miao et al.. Int J Mol Med. 2013. α-Lipoic acid attenuates obesity-associated hippocampal neuroinflammation and increases the levels of brain-derived neurotrophic factor in ovariectomized rats fed a high-fat … doi:10.3892/ijmm.2013.1482 PubMed

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