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WeightCited

Glutamine for Obesity

C Some Evidence Limited evidence from small studies, but some positive signals exist.

RCT (n=66) found 30 g/day reduced weight and waist circumference comparably to isonitrogenous protein control. Systematic review of 7 trials found improved inflammatory markers and gut barrier function in obese patients. Evidence is preliminary but growing, with benefits potentially mediated through the gut-metabolic axis.

C

The Bottom Line

RCT (n=66) found 30 g/day reduced weight and waist circumference comparably to isonitrogenous protein control. Systematic review of 7 trials found improved inflammatory markers and gut barrier function in obese patients. Evidence is preliminary but growing, with benefits potentially mediated through the gut-metabolic axis.

Key Statistics

7

Studies

300

Participants

↑

Positive

C

Grade

Referenced Papers

Role of L-Arginine in Nitric Oxide Synthesis and Health in Humans. Other
Advances in experimental … 2021 206 citations
[Nutrition in the prevention and healing of chronic wounds. Importance in improving the diabetic foot]. Other
Nutricion hospitalaria 2021 20 citations
The Na+/Cl--Coupled, Broad-Specific, Amino Acid Transporter SLC6A14 (ATB0,+): Emerging Roles in Multiple Diseases and Therapeutic Potential for Treatment and Diagnosis. Review
The AAPS journal 2017

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Commonly Used Dosages

general:
5-10 g/day
guthealth:
10-20 g/day
exerciserecovery:
5-10 g pre/post workout

Upper limit: 40 g/day (well-tolerated in clinical trials)

Best taken: Between meals or pre/post-exercise; may add to protein shakes

Safety & Side Effects

Reported Side Effects

  • ⚠ Bloating
  • ⚠ GI discomfort
  • ⚠ Constipation

Known Interactions

  • ● Lactulose (may reduce effectiveness)
  • ● Anticonvulsants (may reduce effectiveness)

Tolerable upper intake: 40 g/day (well-tolerated in clinical trials)

Always consult your healthcare provider before starting any supplement.

Frequently Asked Questions

Does Glutamine help with Obesity?
Based on 7 studies with 300 participants, there is limited but promising evidence that Glutamine may support Obesity management. Our evidence grade is C (Some Evidence).
How much Glutamine should I take for Obesity?
Studies have used various dosages. A commonly studied range is 5-10 g/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Glutamine?
Reported side effects may include Bloating, GI discomfort, Constipation. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Glutamine and Obesity?
We rate the evidence as Grade C (Some Evidence). This rating is based on 7 peer-reviewed studies with 300 total participants. The overall direction of effect is positive.

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References

  
    
    
    
  1. 
      [1]
      Guoyao Wu et al..
      Adv Exp Med Biol.
      2021.
      Role of L-Arginine in Nitric Oxide Synthesis and Health in Humans.
      doi:10.1007/978-3-030-74180-8_10
      PubMed
    
    2. 
    
    
  2. 
      [2]
      Rosa María Martínez García et al..
      Nutr Hosp.
      2021.
      [Nutrition in the prevention and healing of chronic wounds. Importance in improving the diabetic foot].
      doi:10.20960/nh.03800
      PubMed
    
    3. 
    
    
  3. 
      [3]
      Mohd Omar F Sikder et al..
      AAPS J.
      2017.
      The Na+/Cl--Coupled, Broad-Specific, Amino Acid Transporter SLC6A14 (ATB0,+): Emerging Roles in Multiple Diseases and Therapeutic Potential for Treatment and Diagnosis.
      doi:10.1208/s12248-017-0164-7
      PubMed
    
    4. 
    
  















    

        FDA Disclaimer:
        These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.