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WeightCited

Glutamine for Obesity

C Some Evidence Limited evidence from small studies, but some positive signals exist.

RCT (n=66) found 30 g/day reduced weight and waist circumference comparably to isonitrogenous protein control. Systematic review of 7 trials found improved inflammatory markers and gut barrier function in obese patients. Evidence is preliminary but growing, with benefits potentially mediated through the gut-metabolic axis.

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            C

        

        

            
The Bottom Line

            
            
RCT (n=66) found 30 g/day reduced weight and waist circumference comparably to isonitrogenous protein control. Systematic review of 7 trials found improved inflammatory markers and gut barrier function in obese patients. Evidence is preliminary but growing, with benefits potentially mediated through the gut-metabolic axis.

            
            
        

    










    

  
Key Study Findings





    

        
        

            

                
                    Other
                
                
                
                
            

            
                [Nutrition in the prevention and healing of chronic wounds. Importance in improving the diabetic foot].
            
            

                
                Dose: None
                
                
                vs: None
                
                
                Outcome: None
                
                
                Effect: None
                
                
                None
                
            

            
            
Population: chronic wounds and have been linked to delayed wound healing and dehiscence

            
        

        
        

            

                
                    Review
                
                
                
                
            

            
                Role of L-Arginine in Nitric Oxide Synthesis and Health in Humans.
            
            

                
                Dose: None
                
                
                vs: None
                
                
                Outcome: None
                
                
                Effect: None
                
                
                None
                
            

            
            
Population: Humans (general)

            
        

        
        

            

                
                    Review
                
                
                
                
            

            
                The Na+/Cl--Coupled, Broad-Specific, Amino Acid Transporter SLC6A14 (ATB0,+): Emerging Roles in Multiple Diseases and Therapeutic …
            
            

                
                Dose: None
                
                
                vs: None
                
                
                Outcome: None
                
                
                Effect: None
                
                
                None
                
            

            
            
Population: Cancer patients (SLC6A14 transporter review)

            
        

        
    







    
    

        
        

            

  
Key Statistics





            


    

        
7

        
Studies

    

    

        
300

        
Participants

    

    

        
            
            ↑
            
        
        
Positive

    

    

        C

        
Grade

    




        


        
        
        

            

  
Referenced Papers





            

                
                

                    

                        
                            Role of L-Arginine in Nitric Oxide Synthesis and Health in Humans.
                        
                        
                            
                                Other
                            
                            
                            
                        
                    

                    

                        Advances in experimental …
                        2021
                        
                        206 citations
                        
                    

                

                
                

                    

                        
                            [Nutrition in the prevention and healing of chronic wounds. Importance in improving the diabetic foot].
                        
                        
                            
                                Other
                            
                            
                            
                        
                    

                    

                        Nutricion hospitalaria
                        2021
                        
                        20 citations
                        
                    

                

                
                

                    

                        
                            The Na+/Cl--Coupled, Broad-Specific, Amino Acid Transporter SLC6A14 (ATB0,+): Emerging Roles in Multiple Diseases and Therapeutic Potential for Treatment and Diagnosis.
                        
                        
                            
                                Review
                            
                            
                            
                        
                    

                    

                        The AAPS journal
                        2017
                        
                    

                

                
            

        

        

        
        
        

            

  
Dosage & Usage





            
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units


            
            

                
Commonly Used Dosages

                

                    
                    

                        
general:

                        
5-10 g/day

                    

                    
                    

                        
guthealth:

                        
10-20 g/day

                    

                    
                    

                        
exerciserecovery:

                        
5-10 g pre/post workout

                    

                    
                

                
                

                    Upper limit: 40 g/day (well-tolerated in clinical trials)
                

                
            

            

            
            

                
Dosages Studied in Research

                

                    

                        
                            

                                Dosage
                                Duration
                                Effect
                                N
                            

                        
                        
                            
                            

                                None
                                --
                                
                                    
                                    Positive
                                    
                                
                                --
                            

                            
                            

                                None
                                --
                                
                                    
                                    Mixed
                                    
                                
                                --
                            

                            
                            

                                None
                                --
                                
                                    
                                    Mixed
                                    
                                
                                --
                            

                            
                        
                    

                

            

            

            
            

                Best taken: Between meals or pre/post-exercise; may add to protein shakes
            

            
        

        

        
        
        

            

  
Safety & Side Effects





            

                
                

                    
Reported Side Effects

                    
    
                        
                        
  • 
                            ⚠
                            Bloating
                        
    • 
                        
                        
  • 
                            ⚠
                            GI discomfort
                        
    • 
                        
                        
  • 
                            ⚠
                            Constipation
                        
    • 
                        
                    

                

                

                
                

                    
Known Interactions

                    
    
                        
                        
  • 
                            ●
                            Lactulose (may reduce effectiveness)
                        
    • 
                        
                        
  • 
                            ●
                            Anticonvulsants (may reduce effectiveness)
                        
    • 
                        
                    

                

                

                
                

                    

                        Tolerable upper intake: 40 g/day (well-tolerated in clinical trials)
                    

                

                
            

            

                Always consult your healthcare provider before starting any supplement.
            

        

        

        
        
        

            

  
Frequently Asked Questions





            




    
    

        
            Does Glutamine help with Obesity?
            
        
        

            Based on 7 studies with 300 participants, there is limited but promising evidence that Glutamine may support Obesity management. Our evidence grade is C (Some Evidence).
        

    

    
    

        
            How much Glutamine should I take for Obesity?
            
        
        

            Studies have used various dosages. A commonly studied range is 5-10 g/day. Always consult your healthcare provider before starting any supplement regimen.
        

    

    
    

        
            Are there side effects of Glutamine?
            
        
        

            Reported side effects may include Bloating, GI discomfort, Constipation. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
        

    

    
    

        
            How strong is the evidence for Glutamine and Obesity?
            
        
        

            We rate the evidence as Grade C (Some Evidence). This rating is based on 7 peer-reviewed studies with 300 total participants. The overall direction of effect is positive.
        

    

    




        

        

        
        
        

            

  




            

                
                
                

                
            

        

        

    


    
    






  
References

  
    
    
    
  1. 
      [1]
      Guoyao Wu et al..
      Adv Exp Med Biol.
      2021.
      Role of L-Arginine in Nitric Oxide Synthesis and Health in Humans.
      doi:10.1007/978-3-030-74180-8_10
      PubMed
    
    2. 
    
    
  2. 
      [2]
      Rosa María Martínez García et al..
      Nutr Hosp.
      2021.
      [Nutrition in the prevention and healing of chronic wounds. Importance in improving the diabetic foot].
      doi:10.20960/nh.03800
      PubMed
    
    3. 
    
    
  3. 
      [3]
      Mohd Omar F Sikder et al..
      AAPS J.
      2017.
      The Na+/Cl--Coupled, Broad-Specific, Amino Acid Transporter SLC6A14 (ATB0,+): Emerging Roles in Multiple Diseases and Therapeutic Potential for Treatment and Diagnosis.
      doi:10.1208/s12248-017-0164-7
      PubMed
    
    4. 
    
  















    

        FDA Disclaimer:
        These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.