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Ashwagandha untuk Cortisol-Related Weight Gain

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Systematic review of 12 RCTs found significant cortisol reduction (27.9% in key study). An 8-week RCT (n=52) found reductions in body weight by 3.0% and BMI by 3.0% in chronically stressed adults. Ashwagandha addresses cortisol-driven visceral fat accumulation.

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Kesimpulan

Systematic review of 12 RCTs found significant cortisol reduction (27.9% in key study). An 8-week RCT (n=52) found reductions in body weight by 3.0% and BMI by 3.0% in chronically stressed adults. Ashwagandha addresses cortisol-driven visceral fat accumulation.

Key Study Findings

RCT n=90 12 weeks Double-blind
A New Ashwagandha Formulation (Zenroot™) Alleviates Stress and Anxiety Symptoms While Improving Mood and Sleep …
Dose: 125 mg Zenroot (Ashwagandha with 1.5% total withanolides) daily vs: Placebo Efek: None < 0.05
Review
Can Ashwagandha Benefit the Endocrine System?-A Review.
Dose: None vs: Placebo Efek: None None

Key Statistics

12

Studi

700

Peserta

Positive

B

Peringkat

Referenced Papers

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Dosis yang Umum Digunakan

sleep:
600 mg at bedtime
general:
300-600 mg/day KSM-66 standardized extract
stresscortisol:
600 mg/day

Batas atas: 1,200 mg/day; rare liver injury cases at very high or prolonged doses

Dosis yang Diteliti dalam Penelitian

Dosis Durasi Efek N
125 mg Zenroot (Ashwagandha with 1.5% total withanolides) daily 12 weeks Positive 90
None -- Positive --

Waktu terbaik diminum: Morning for energy/cortisol; evening for sleep; with meals

Safety & Side Effects

Efek Samping yang Dilaporkan

  • Drowsiness
  • GI discomfort
  • Rare liver injury at very high doses
  • Thyroid hormone changes

Interaksi yang Diketahui

  • Thyroid medications (may increase thyroid hormone levels)
  • Sedatives (additive drowsiness)
  • Immunosuppressants (may stimulate immune system)
  • Diabetes medications (may lower blood sugar)

Asupan atas yang dapat ditoleransi: 1,200 mg/day; rare liver injury cases at very high or prolonged doses

Selalu konsultasikan dengan tenaga kesehatan Anda sebelum memulai suplemen apa pun.Selalu konsultasikan dengan penyedia layanan kesehatan Anda sebelum memulai suplemen apa pun.

Frequently Asked Questions

Does Ashwagandha help with Cortisol-Related Weight Gain?
Based on 12 studies with 700 participants, there is moderate evidence from clinical studies that Ashwagandha may support Cortisol-Related Weight Gain management. Our evidence grade is B (Good Evidence).
How much Ashwagandha should I take for Cortisol-Related Weight Gain?
Studies have used various dosages. A commonly studied range is 600 mg at bedtime. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Ashwagandha?
Reported side effects may include Drowsiness, GI discomfort, Rare liver injury at very high doses, Thyroid hormone changes. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Ashwagandha and Cortisol-Related Weight Gain?
We rate the evidence as Grade B (Good Evidence). This rating is based on 12 peer-reviewed studies with 700 total participants. The overall direction of effect is positive.

Bahan lain untuk Cortisol-Related Weight Gain

References

  1. [1] Manasvi Mahadevan et al.. Adv Ther. 2025. A New Ashwagandha Formulation (Zenroot™) Alleviates Stress and Anxiety Symptoms While Improving Mood and Sleep Quality: A Randomized, Double-Blind, Placebo-Controlled … doi:10.1007/s12325-025-03327-z PubMed
  2. [2] Michał Wiciński et al.. Int J Mol Sci. 2023. Can Ashwagandha Benefit the Endocrine System?-A Review. doi:10.3390/ijms242216513 PubMed
  3. [3] Karen Savage et al.. Phytother Res. 2018. GABA-modulating phytomedicines for anxiety: A systematic review of preclinical and clinical evidence. doi:10.1002/ptr.5940 PubMed

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