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Green Tea Extract (EGCG) untuk Obesity

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Cochrane review of 14 RCTs found EGCG plus caffeine produces modest but statistically significant weight loss of 1.0-1.3 kg over 12 weeks. Twenty-four-hour energy expenditure increased approximately 5% and fat oxidation approximately 16%, with effects more pronounced in Asian populations and habitual low-caffeine consumers.

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Kesimpulan

            
            
Cochrane review of 14 RCTs found EGCG plus caffeine produces modest but statistically significant weight loss of 1.0-1.3 kg over 12 weeks. Twenty-four-hour energy expenditure increased approximately 5% and fat oxidation approximately 16%, with effects more pronounced in Asian populations and habitual low-caffeine consumers.

            
            
        

    










    

  
Key Study Findings





    

        
        

            

                
                    Review
                
                
                
                
            

            
                Inflammation, a Double-Edge Sword for Cancer and Other Age-Related Diseases.
            
            

                
                Dose: None
                
                
                vs: None
                
                
                Outcome: None
                
                
                Efek: None
                
                
                None
                
            

            
            
Populasi: None

            
        

        
        

            

                
                    In Vitro
                
                
                
                8 weeks
                
                
            

            
                Green tea extract improves high fat diet-induced hypothalamic inflammation, without affecting the serotoninergic system.
            
            

                
                Dose: None
                
                
                vs: High-fat diet control
                
                
                Outcome: Hypothalamic inflammation markers (TLR4 pathway)
                
                
                Efek: None
                
                
                None
                
            

            
            
Populasi: Male Swiss mice fed high-fat diet

            
        

        
    







    
    

        
        

            

  
Key Statistics





            


    

        
14

        
Studi

    

    

        
1500

        
Peserta

    

    

        
            
            ↑
            
        
        
Positive

    

    

        B

        
Peringkat

    




        


        
        
        

            

  
Referenced Papers





            

                
                

                    

                        
                            Inflammation, a Double-Edge Sword for Cancer and Other Age-Related Diseases.
                        
                        
                            
                                Review
                            
                            
                            
                        
                    

                    

                        Frontiers in immunology
                        2018
                        
                        200 sitasi
                        
                    

                

                
                

                    

                        
                            Green tea extract improves high fat diet-induced hypothalamic inflammation, without affecting the serotoninergic system.
                        
                        
                            
                                Other
                            
                            
                            
                        
                    

                    

                        The Journal of …
                        2014
                        
                        33 sitasi
                        
                    

                

                
            

        

        

        
        
        

            

  
Dosage & Usage





            
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units


            
            

                
Dosis yang Umum Digunakan

                

                    
                    

                        
general:

                        
250-500 mg/day standardized to 50% EGCG

                    

                    
                    

                        
equivalent:

                        
3-5 cups green tea/day

                    

                    
                    

                        
weightmanagement:

                        
400-800 mg EGCG/day

                    

                    
                

                
                

                    Batas atas: 800 mg EGCG/day (hepatotoxicity risk above this; rare but documented)
                

                
            

            

            
            

                
Dosis yang Diteliti dalam Penelitian

                

                    

                        
                            

                                Dosis
                                Durasi
                                Efek
                                N
                            

                        
                        
                            
                            

                                None
                                --
                                
                                    
                                    Positive
                                    
                                
                                --
                            

                            
                            

                                None
                                8 weeks
                                
                                    
                                    Positive
                                    
                                
                                --
                            

                            
                        
                    

                

            

            

            
            

                Waktu terbaik diminum: With meals (reduces nausea risk); avoid on empty stomach; space from iron-containing foods/supp
            

            
        

        

        
        
        

            

  
Safety & Side Effects





            

                
                

                    
Efek Samping yang Dilaporkan

                    
    
                        
                        
  • 
                            ⚠
                            Nausea on empty stomach
                        
    • 
                        
                        
  • 
                            ⚠
                            Insomnia (caffeine content)
                        
    • 
                        
                        
  • 
                            ⚠
                            Rare hepatotoxicity at high doses
                        
    • 
                        
                        
  • 
                            ⚠
                            Reduced iron absorption
                        
    • 
                        
                    

                

                

                
                

                    
Interaksi yang Diketahui

                    
    
                        
                        
  • 
                            ●
                            Nadolol (reduced bioavailability)
                        
    • 
                        
                        
  • 
                            ●
                            Iron supplements (reduced absorption)
                        
    • 
                        
                        
  • 
                            ●
                            Blood thinners (theoretical)
                        
    • 
                        
                        
  • 
                            ●
                            Other stimulants (additive effects)
                        
    • 
                        
                    

                

                

                
                

                    

                        Asupan atas yang dapat ditoleransi: 800 mg EGCG/day (hepatotoxicity risk above this; rare but documented)
                    

                

                
            

            

                Selalu konsultasikan dengan tenaga kesehatan Anda sebelum memulai suplemen apa pun.Selalu konsultasikan dengan penyedia layanan kesehatan Anda sebelum memulai suplemen apa pun.
            

        

        

        
        
        

            

  
Frequently Asked Questions





            




    
    

        
            Does Green Tea Extract (EGCG) help with Obesity?
            
        
        

            Based on 14 studies with 1,500 participants, there is moderate evidence from clinical studies that Green Tea Extract (EGCG) may support Obesity management. Our evidence grade is B (Good Evidence).
        

    

    
    

        
            How much Green Tea Extract (EGCG) should I take for Obesity?
            
        
        

            Studies have used various dosages. A commonly studied range is 250-500 mg/day standardized to 50% EGCG. Always consult your healthcare provider before starting any supplement regimen.
        

    

    
    

        
            Are there side effects of Green Tea Extract (EGCG)?
            
        
        

            Reported side effects may include Nausea on empty stomach, Insomnia (caffeine content), Rare hepatotoxicity at high doses, Reduced iron absorption. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
        

    

    
    

        
            How strong is the evidence for Green Tea Extract (EGCG) and Obesity?
            
        
        

            We rate the evidence as Grade B (Good Evidence). This rating is based on 14 peer-reviewed studies with 1,500 total participants. The overall direction of effect is positive.
        

    

    




        

        

        
        
        

            

  




            

                
                
                

                
                
                
            

        

        

    


    
    






  
References

  
    
    
    
  1. 
      [1]
      Subash Chandra Gupta et al..
      Front Immunol.
      2018.
      Inflammation, a Double-Edge Sword for Cancer and Other Age-Related Diseases.
      doi:10.3389/fimmu.2018.02160
      PubMed
    
    2. 
    
    
  2. 
      [2]
      Marcos H Okuda et al..
      J Nutr Biochem.
      2014.
      Green tea extract improves high fat diet-induced hypothalamic inflammation, without affecting the serotoninergic system.
      doi:10.1016/j.jnutbio.2014.05.012
      PubMed
    
    3. 
    
  















    

        Penafian FDA:
        Pernyataan-pernyataan ini belum dievaluasi oleh Food and Drug Administration. Produk dan informasi di situs web ini tidak dimaksudkan untuk mendiagnosis, mengobati, menyembuhkan, atau mencegah penyakit apa pun. Peringkat bukti yang disajikan didasarkan pada analisis kami terhadap penelitian yang ditinjau sejawat dan tidak merupakan saran medis. Selalu konsultasikan dengan penyedia layanan kesehatan Anda sebelum memulai regimen suplemen apa pun.