CLA untuk Obesity
B Bukti Setidaknya satu uji coba acak mendukung hal ini, dengan hasil yang sebagian besar konsisten.Cochrane meta-analysis of 18 RCTs (n=807) found CLA at 3.2 g/day reduced body fat mass by 1.33 kg over 6-12 months without significant change in body weight, suggesting lean mass preservation. A 2-year RCT (n=134) found sustained fat reduction. Effects are modest and require long-term use.
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B
Kesimpulan
Cochrane meta-analysis of 18 RCTs (n=807) found CLA at 3.2 g/day reduced body fat mass by 1.33 kg over 6-12 months without significant change in body weight, suggesting lean mass preservation. A 2-year RCT (n=134) found sustained fat reduction. Effects are modest and require long-term use.
Key Study Findings
Review
Dietary Fiber: A Comprehensive Review of Its Sources, Health Benefits, and Mechanisms Driving Nutraceutical Effects.
Dose: None
vs: None
Outcome: None
Efek: None
None
Populasi: None
systematic review and meta-analysis
Causal factors for migraine in Mendelian randomization studies: a systematic review and meta-analysis.
Dose: None
vs: Placebo
Efek: None
None
Other
The omega effect: Harnessing fish oil for health.
Dose: None
vs: None
Outcome: None
Efek: None
None
Populasi: None
Review
The evidence for probiotics in the treatment of digestive disorders in the pediatric population.
Dose: None
vs: None
Outcome: None
Efek: None
None
Populasi: Pediatric population
Observational Study
n=65
Open-label
Incidence and Characterization of SIBO in NAFLD Patients.
Dose: None
vs: None
Outcome: SIBO prevalence in NAFLD patients
Efek: SIBO in 37%; post-treatment 4% remained+
None
Populasi: Adults with NAFLD diagnosed via FibroScan
Review
Current understanding of antibiotic-associated dysbiosis and approaches for its management.
Dose: Various probiotic interventions
vs: None
Outcome: Dysbiosis management strategies
Efek: None
None
Populasi: Patients with antibiotic-associated dysbiosis
Key Statistics
18
Studi
807
Peserta
↑
Positive
B
Peringkat
Referenced Papers
The Journal of …
2026
The evidence for probiotics in the treatment of digestive disorders in the pediatric population.
Review
Journal of gastroenterology …
2025
10 sitasi
Endocrine
2025
2 sitasi
Causal factors for migraine in Mendelian randomization studies: a systematic review and meta-analysis.
Systematic Review
Frontiers in neurology
2025
1 sitasi
Recent advances in …
2025
1 sitasi
Euroasian journal of …
2025
Atherosclerosis
2025
Therapeutic advances in …
2023
97 sitasi
Cordyceps inhibits ceramide biosynthesis and improves insulin resistance and hepatic steatosis.
Other
Scientific reports
2022
22 sitasi
Foods (Basel, Switzerland)
2022
9 sitasi
World journal of …
2022
8 sitasi
Advances in experimental …
2021
206 sitasi
Microorganisms
2021
47 sitasi
Nutrients
2021
36 sitasi
Scientific reports
2020
50 sitasi
American journal of …
2019
117 sitasi
Best practice & …
2017
14 sitasi
Saudi journal of …
2015
32 sitasi
Minerva ginecologica
2011
19 sitasi
Lipids in health …
2010
7 sitasi
The British journal …
2002
The American journal …
2000
742 sitasi
Dietary fructans.
Review
Annual review of …
1998
264 sitasi
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Dosis yang Umum Digunakan
- general:
- 3.2-6.4 g/day mixed isomers
- bodycomposition:
- 3.4 g/day (50:50 c9,t11:t10,c12 blend)
- minimumeffective:
- 3.2 g/day for ≥12 weeks
Batas atas: 6 g/day; higher doses may worsen insulin sensitivity
Dosis yang Diteliti dalam Penelitian
| Dosis | Durasi | Efek | N |
|---|---|---|---|
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| None | -- | Positive | 65 |
| Various probiotic interventions | -- | Positive | -- |
| None | -- | Mixed | -- |
| Zinc carnosine 75 mg twice daily for 10 days | -- | Positive | 92 |
Waktu terbaik diminum: With meals; divide dose across 2-3 meals
Safety & Side Effects
Efek Samping yang Dilaporkan
- ⚠ GI discomfort
- ⚠ May worsen insulin sensitivity at high doses
- ⚠ Possible HDL reduction
- ⚠ Fatty liver (in some rodent studies)
Interaksi yang Diketahui
- ● Diabetes medications (may affect insulin sensitivity)
- ● Blood thinners (theoretical)
Asupan atas yang dapat ditoleransi: 6 g/day; higher doses may worsen insulin sensitivity
Selalu konsultasikan dengan tenaga kesehatan Anda sebelum memulai suplemen apa pun.Selalu konsultasikan dengan penyedia layanan kesehatan Anda sebelum memulai suplemen apa pun.
Frequently Asked Questions
Does CLA help with Obesity?
Based on 18 studies with 807 participants, there is moderate evidence from clinical studies that CLA may support Obesity management. Our evidence grade is B (Good Evidence).
How much CLA should I take for Obesity?
Studies have used various dosages. A commonly studied range is 3.2-6.4 g/day mixed isomers. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of CLA?
Reported side effects may include GI discomfort, May worsen insulin sensitivity at high doses, Possible HDL reduction, Fatty liver (in some rodent studies). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for CLA and Obesity?
We rate the evidence as Grade B (Good Evidence). This rating is based on 18 peer-reviewed studies with 807 total participants. The overall direction of effect is positive.
Related Evidence
References
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Penafian FDA: Pernyataan-pernyataan ini belum dievaluasi oleh Food and Drug Administration. Produk dan informasi di situs web ini tidak dimaksudkan untuk mendiagnosis, mengobati, menyembuhkan, atau mencegah penyakit apa pun. Peringkat bukti yang disajikan didasarkan pada analisis kami terhadap penelitian yang ditinjau sejawat dan tidak merupakan saran medis. Selalu konsultasikan dengan penyedia layanan kesehatan Anda sebelum memulai regimen suplemen apa pun.