CLA cho Obesity
B Bằng chứng Ít nhất một thử nghiệm ngẫu nhiên ủng hộ điều này, với các kết quả phần lớn nhất quán.Cochrane meta-analysis of 18 RCTs (n=807) found CLA at 3.2 g/day reduced body fat mass by 1.33 kg over 6-12 months without significant change in body weight, suggesting lean mass preservation. A 2-year RCT (n=134) found sustained fat reduction. Effects are modest and require long-term use.
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B
Kết luận
Cochrane meta-analysis of 18 RCTs (n=807) found CLA at 3.2 g/day reduced body fat mass by 1.33 kg over 6-12 months without significant change in body weight, suggesting lean mass preservation. A 2-year RCT (n=134) found sustained fat reduction. Effects are modest and require long-term use.
Key Study Findings
Review
Dietary Fiber: A Comprehensive Review of Its Sources, Health Benefits, and Mechanisms Driving Nutraceutical Effects.
Dose: None
so với: None
Outcome: None
Hiệu quả: None
None
Đối tượng nghiên cứu: None
systematic review and meta-analysis
Causal factors for migraine in Mendelian randomization studies: a systematic review and meta-analysis.
Dose: None
so với: Placebo
Hiệu quả: None
None
Other
The omega effect: Harnessing fish oil for health.
Dose: None
so với: None
Outcome: None
Hiệu quả: None
None
Đối tượng nghiên cứu: None
Review
The evidence for probiotics in the treatment of digestive disorders in the pediatric population.
Dose: None
so với: None
Outcome: None
Hiệu quả: None
None
Đối tượng nghiên cứu: Pediatric population
Observational Study
n=65
Open-label
Incidence and Characterization of SIBO in NAFLD Patients.
Dose: None
so với: None
Outcome: SIBO prevalence in NAFLD patients
Hiệu quả: SIBO in 37%; post-treatment 4% remained+
None
Đối tượng nghiên cứu: Adults with NAFLD diagnosed via FibroScan
Review
Current understanding of antibiotic-associated dysbiosis and approaches for its management.
Dose: Various probiotic interventions
so với: None
Outcome: Dysbiosis management strategies
Hiệu quả: None
None
Đối tượng nghiên cứu: Patients with antibiotic-associated dysbiosis
Key Statistics
18
Nghiên cứu
807
Người tham gia
↑
Positive
B
Xếp hạng
Referenced Papers
The Journal of …
2026
The evidence for probiotics in the treatment of digestive disorders in the pediatric population.
Review
Journal of gastroenterology …
2025
10 trích dẫn
Endocrine
2025
2 trích dẫn
Causal factors for migraine in Mendelian randomization studies: a systematic review and meta-analysis.
Systematic Review
Frontiers in neurology
2025
1 trích dẫn
Recent advances in …
2025
1 trích dẫn
Euroasian journal of …
2025
Atherosclerosis
2025
Therapeutic advances in …
2023
97 trích dẫn
Cordyceps inhibits ceramide biosynthesis and improves insulin resistance and hepatic steatosis.
Other
Scientific reports
2022
22 trích dẫn
Foods (Basel, Switzerland)
2022
9 trích dẫn
World journal of …
2022
8 trích dẫn
Advances in experimental …
2021
206 trích dẫn
Microorganisms
2021
47 trích dẫn
Nutrients
2021
36 trích dẫn
Scientific reports
2020
50 trích dẫn
American journal of …
2019
117 trích dẫn
Best practice & …
2017
14 trích dẫn
Saudi journal of …
2015
32 trích dẫn
Minerva ginecologica
2011
19 trích dẫn
Lipids in health …
2010
7 trích dẫn
The British journal …
2002
The American journal …
2000
742 trích dẫn
Dietary fructans.
Review
Annual review of …
1998
264 trích dẫn
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Liều lượng thường dùng
- general:
- 3.2-6.4 g/day mixed isomers
- bodycomposition:
- 3.4 g/day (50:50 c9,t11:t10,c12 blend)
- minimumeffective:
- 3.2 g/day for ≥12 weeks
Giới hạn trên: 6 g/day; higher doses may worsen insulin sensitivity
Liều lượng đã nghiên cứu
| Liều lượng | Thời gian | Hiệu quả | N |
|---|---|---|---|
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| None | -- | Positive | 65 |
| Various probiotic interventions | -- | Positive | -- |
| None | -- | Mixed | -- |
| Zinc carnosine 75 mg twice daily for 10 days | -- | Positive | 92 |
Thời điểm dùng tốt nhất: With meals; divide dose across 2-3 meals
Safety & Side Effects
Tác dụng phụ đã được báo cáo
- ⚠ GI discomfort
- ⚠ May worsen insulin sensitivity at high doses
- ⚠ Possible HDL reduction
- ⚠ Fatty liver (in some rodent studies)
Tương tác đã biết
- ● Diabetes medications (may affect insulin sensitivity)
- ● Blood thinners (theoretical)
Mức hấp thụ tối đa cho phép: 6 g/day; higher doses may worsen insulin sensitivity
Luôn tham khảo ý kiến bác sĩ trước khi bắt đầu sử dụng bất kỳ thực phẩm bổ sung nào.Luôn tham khảo ý kiến chuyên gia y tế trước khi sử dụng bất kỳ thực phẩm chức năng nào.
Frequently Asked Questions
Does CLA help with Obesity?
Based on 18 studies with 807 participants, there is moderate evidence from clinical studies that CLA may support Obesity management. Our evidence grade is B (Good Evidence).
How much CLA should I take for Obesity?
Studies have used various dosages. A commonly studied range is 3.2-6.4 g/day mixed isomers. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of CLA?
Reported side effects may include GI discomfort, May worsen insulin sensitivity at high doses, Possible HDL reduction, Fatty liver (in some rodent studies). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for CLA and Obesity?
We rate the evidence as Grade B (Good Evidence). This rating is based on 18 peer-reviewed studies with 807 total participants. The overall direction of effect is positive.
Related Evidence
Các thành phần khác cho Obesity
References
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- [9] Ying Li et al.. Sci Rep. 2022. Cordyceps inhibits ceramide biosynthesis and improves insulin resistance and hepatic steatosis. doi:10.1038/s41598-022-11219-3 PubMed
- [10] Monica Tognocchi et al.. Foods. 2022. Supplementation of Enriched Polyunsaturated Fatty Acids and CLA Cheese on High Fat Diet: Effects on Lipid Metabolism and Fat Profile. doi:10.3390/foods11030398 PubMed
- [11] Nour Ibrahim et al.. World J Clin Cases. 2022. Zinc carnosine-based modified bismuth quadruple therapy vs standard triple therapy for Helicobacter pylori eradication: A randomized controlled study. doi:10.12998/wjcc.v10.i1.227 PubMed
- [12] Guoyao Wu et al.. Adv Exp Med Biol. 2021. Role of L-Arginine in Nitric Oxide Synthesis and Health in Humans. doi:10.1007/978-3-030-74180-8_10 PubMed
- [13] Luisa Marras et al.. Microorganisms. 2021. The Role of Bifidobacteria in Predictive and Preventive Medicine: A Focus on Eczema and Hypercholesterolemia. doi:10.3390/microorganisms9040836 PubMed
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- [16] Shi-Jun Yue et al.. Am J Physiol Endocrinol Metab. 2019. Berberine alleviates insulin resistance by reducing peripheral branched-chain amino acids. doi:10.1152/ajpendo.00256.2018 PubMed
- [17] Omid Jazayeri et al.. Best Pract Res Clin Gastroenterol. 2017. Lifestyle alters GUT-bacteria function: Linking immune response and host. doi:10.1016/j.bpg.2017.09.009 PubMed
- [18] Luigi Russo et al.. Saudi J Gastroenterol. 2015. Partially hydrolyzed guar gum in the treatment of irritable bowel syndrome with constipation: effects of gender, age, and body mass … doi:10.4103/1319-3767.153835 PubMed
- [19] C Agosta et al.. Minerva Ginecol. 2011. Randomized controlled study on clinical efficacy of isoflavones plus Lactobacillus sporogenes, associated or not with a natural anxiolytic agent in … PubMed
- [20] Aurelio Ocaña et al.. Lipids Health Dis. 2010. In vitro study of the effect of diesterified alkoxyglycerols with conjugated linoleic acid on adipocyte inflammatory mediators. doi:10.1186/1476-511X-9-36 PubMed
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