CLA per Obesity
B Evidenze Almeno un trial randomizzato lo supporta, con risultati per lo più coerenti.Cochrane meta-analysis of 18 RCTs (n=807) found CLA at 3.2 g/day reduced body fat mass by 1.33 kg over 6-12 months without significant change in body weight, suggesting lean mass preservation. A 2-year RCT (n=134) found sustained fat reduction. Effects are modest and require long-term use.
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B
In sintesi
Cochrane meta-analysis of 18 RCTs (n=807) found CLA at 3.2 g/day reduced body fat mass by 1.33 kg over 6-12 months without significant change in body weight, suggesting lean mass preservation. A 2-year RCT (n=134) found sustained fat reduction. Effects are modest and require long-term use.
Key Study Findings
Review
Dietary Fiber: A Comprehensive Review of Its Sources, Health Benefits, and Mechanisms Driving Nutraceutical Effects.
Dose: None
vs: None
Outcome: None
Effetto: None
None
Popolazione: None
systematic review and meta-analysis
Causal factors for migraine in Mendelian randomization studies: a systematic review and meta-analysis.
Dose: None
vs: Placebo
Effetto: None
None
Other
The omega effect: Harnessing fish oil for health.
Dose: None
vs: None
Outcome: None
Effetto: None
None
Popolazione: None
Review
The evidence for probiotics in the treatment of digestive disorders in the pediatric population.
Dose: None
vs: None
Outcome: None
Effetto: None
None
Popolazione: Pediatric population
Observational Study
n=65
Open-label
Incidence and Characterization of SIBO in NAFLD Patients.
Dose: None
vs: None
Outcome: SIBO prevalence in NAFLD patients
Effetto: SIBO in 37%; post-treatment 4% remained+
None
Popolazione: Adults with NAFLD diagnosed via FibroScan
Review
Current understanding of antibiotic-associated dysbiosis and approaches for its management.
Dose: Various probiotic interventions
vs: None
Outcome: Dysbiosis management strategies
Effetto: None
None
Popolazione: Patients with antibiotic-associated dysbiosis
Key Statistics
18
Studi
807
Partecipanti
↑
Positive
B
Grado
Referenced Papers
The Journal of …
2026
The evidence for probiotics in the treatment of digestive disorders in the pediatric population.
Review
Journal of gastroenterology …
2025
10 citazioni
Endocrine
2025
2 citazioni
Causal factors for migraine in Mendelian randomization studies: a systematic review and meta-analysis.
Systematic Review
Frontiers in neurology
2025
1 citazioni
Recent advances in …
2025
1 citazioni
Euroasian journal of …
2025
Atherosclerosis
2025
Therapeutic advances in …
2023
97 citazioni
Cordyceps inhibits ceramide biosynthesis and improves insulin resistance and hepatic steatosis.
Other
Scientific reports
2022
22 citazioni
Foods (Basel, Switzerland)
2022
9 citazioni
World journal of …
2022
8 citazioni
Advances in experimental …
2021
206 citazioni
Microorganisms
2021
47 citazioni
Nutrients
2021
36 citazioni
Scientific reports
2020
50 citazioni
American journal of …
2019
117 citazioni
Best practice & …
2017
14 citazioni
Saudi journal of …
2015
32 citazioni
Minerva ginecologica
2011
19 citazioni
Lipids in health …
2010
7 citazioni
The British journal …
2002
The American journal …
2000
742 citazioni
Dietary fructans.
Review
Annual review of …
1998
264 citazioni
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Dosaggi di uso comune
- general:
- 3.2-6.4 g/day mixed isomers
- bodycomposition:
- 3.4 g/day (50:50 c9,t11:t10,c12 blend)
- minimumeffective:
- 3.2 g/day for ≥12 weeks
Limite massimo: 6 g/day; higher doses may worsen insulin sensitivity
Dosaggi studiati nella ricerca
| Dosaggio | Durata | Effetto | N |
|---|---|---|---|
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| None | -- | Positive | 65 |
| Various probiotic interventions | -- | Positive | -- |
| None | -- | Mixed | -- |
| Zinc carnosine 75 mg twice daily for 10 days | -- | Positive | 92 |
Momento migliore per l'assunzione: With meals; divide dose across 2-3 meals
Safety & Side Effects
Effetti collaterali segnalati
- ⚠ GI discomfort
- ⚠ May worsen insulin sensitivity at high doses
- ⚠ Possible HDL reduction
- ⚠ Fatty liver (in some rodent studies)
Interazioni note
- ● Diabetes medications (may affect insulin sensitivity)
- ● Blood thinners (theoretical)
Livello di assunzione massimo tollerabile: 6 g/day; higher doses may worsen insulin sensitivity
Consultare sempre il proprio medico prima di iniziare qualsiasi integratore.Consultate sempre il vostro medico prima di iniziare qualsiasi integratore.
Frequently Asked Questions
Does CLA help with Obesity?
Based on 18 studies with 807 participants, there is moderate evidence from clinical studies that CLA may support Obesity management. Our evidence grade is B (Good Evidence).
How much CLA should I take for Obesity?
Studies have used various dosages. A commonly studied range is 3.2-6.4 g/day mixed isomers. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of CLA?
Reported side effects may include GI discomfort, May worsen insulin sensitivity at high doses, Possible HDL reduction, Fatty liver (in some rodent studies). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for CLA and Obesity?
We rate the evidence as Grade B (Good Evidence). This rating is based on 18 peer-reviewed studies with 807 total participants. The overall direction of effect is positive.
Related Evidence
Altri ingredienti per Obesity
References
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- [14] Rosaria Varì et al.. Nutrients. 2021. Obesity-Associated Inflammation: Does Curcumin Exert a Beneficial Role? doi:10.3390/nu13031021 PubMed
- [15] Nuria Martínez-Lozano et al.. Sci Rep. 2020. Evening types have social jet lag and metabolic alterations in school-age children. doi:10.1038/s41598-020-73297-5 PubMed
- [16] Shi-Jun Yue et al.. Am J Physiol Endocrinol Metab. 2019. Berberine alleviates insulin resistance by reducing peripheral branched-chain amino acids. doi:10.1152/ajpendo.00256.2018 PubMed
- [17] Omid Jazayeri et al.. Best Pract Res Clin Gastroenterol. 2017. Lifestyle alters GUT-bacteria function: Linking immune response and host. doi:10.1016/j.bpg.2017.09.009 PubMed
- [18] Luigi Russo et al.. Saudi J Gastroenterol. 2015. Partially hydrolyzed guar gum in the treatment of irritable bowel syndrome with constipation: effects of gender, age, and body mass … doi:10.4103/1319-3767.153835 PubMed
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- [20] Aurelio Ocaña et al.. Lipids Health Dis. 2010. In vitro study of the effect of diesterified alkoxyglycerols with conjugated linoleic acid on adipocyte inflammatory mediators. doi:10.1186/1476-511X-9-36 PubMed
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Avvertenza FDA: Queste affermazioni non sono state valutate dalla Food and Drug Administration. I prodotti e le informazioni presenti su questo sito web non sono destinati a diagnosticare, trattare, curare o prevenire alcuna malattia. I gradi di evidenza presentati si basano sulla nostra analisi della ricerca pubblicata e sottoposta a revisione paritaria e non costituiscono consulenza medica. Consultate sempre il vostro medico prima di iniziare qualsiasi regime di integrazione.