CLA для Obesity
B Доказательства По меньшей мере одно рандомизированное исследование подтверждает это, с в целом согласованными результатами.Cochrane meta-analysis of 18 RCTs (n=807) found CLA at 3.2 g/day reduced body fat mass by 1.33 kg over 6-12 months without significant change in body weight, suggesting lean mass preservation. A 2-year RCT (n=134) found sustained fat reduction. Effects are modest and require long-term use.
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B
Итог
Cochrane meta-analysis of 18 RCTs (n=807) found CLA at 3.2 g/day reduced body fat mass by 1.33 kg over 6-12 months without significant change in body weight, suggesting lean mass preservation. A 2-year RCT (n=134) found sustained fat reduction. Effects are modest and require long-term use.
Key Study Findings
Review
Dietary Fiber: A Comprehensive Review of Its Sources, Health Benefits, and Mechanisms Driving Nutraceutical Effects.
Dose: None
или: None
Outcome: None
Эффект: None
None
Популяция: None
systematic review and meta-analysis
Causal factors for migraine in Mendelian randomization studies: a systematic review and meta-analysis.
Dose: None
или: Placebo
Эффект: None
None
Other
The omega effect: Harnessing fish oil for health.
Dose: None
или: None
Outcome: None
Эффект: None
None
Популяция: None
Review
The evidence for probiotics in the treatment of digestive disorders in the pediatric population.
Dose: None
или: None
Outcome: None
Эффект: None
None
Популяция: Pediatric population
Observational Study
n=65
Open-label
Incidence and Characterization of SIBO in NAFLD Patients.
Dose: None
или: None
Outcome: SIBO prevalence in NAFLD patients
Эффект: SIBO in 37%; post-treatment 4% remained+
None
Популяция: Adults with NAFLD diagnosed via FibroScan
Review
Current understanding of antibiotic-associated dysbiosis and approaches for its management.
Dose: Various probiotic interventions
или: None
Outcome: Dysbiosis management strategies
Эффект: None
None
Популяция: Patients with antibiotic-associated dysbiosis
Key Statistics
18
Исследования
807
Участники
↑
Positive
B
Оценка
Referenced Papers
The Journal of …
2026
The evidence for probiotics in the treatment of digestive disorders in the pediatric population.
Review
Journal of gastroenterology …
2025
10 цитирований
Endocrine
2025
2 цитирований
Causal factors for migraine in Mendelian randomization studies: a systematic review and meta-analysis.
Systematic Review
Frontiers in neurology
2025
1 цитирований
Recent advances in …
2025
1 цитирований
Euroasian journal of …
2025
Atherosclerosis
2025
Therapeutic advances in …
2023
97 цитирований
Cordyceps inhibits ceramide biosynthesis and improves insulin resistance and hepatic steatosis.
Other
Scientific reports
2022
22 цитирований
Foods (Basel, Switzerland)
2022
9 цитирований
World journal of …
2022
8 цитирований
Advances in experimental …
2021
206 цитирований
Microorganisms
2021
47 цитирований
Nutrients
2021
36 цитирований
Scientific reports
2020
50 цитирований
American journal of …
2019
117 цитирований
Best practice & …
2017
14 цитирований
Saudi journal of …
2015
32 цитирований
Minerva ginecologica
2011
19 цитирований
Lipids in health …
2010
7 цитирований
The British journal …
2002
The American journal …
2000
742 цитирований
Dietary fructans.
Review
Annual review of …
1998
264 цитирований
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Часто используемые дозировки
- general:
- 3.2-6.4 g/day mixed isomers
- bodycomposition:
- 3.4 g/day (50:50 c9,t11:t10,c12 blend)
- minimumeffective:
- 3.2 g/day for ≥12 weeks
Верхний предел: 6 g/day; higher doses may worsen insulin sensitivity
Дозировки, изученные в исследованиях
| Дозировка | Длительность | Эффект | N |
|---|---|---|---|
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| None | -- | Positive | 65 |
| Various probiotic interventions | -- | Positive | -- |
| None | -- | Mixed | -- |
| Zinc carnosine 75 mg twice daily for 10 days | -- | Positive | 92 |
Лучшее время приёма: With meals; divide dose across 2-3 meals
Safety & Side Effects
Зарегистрированные побочные эффекты
- ⚠ GI discomfort
- ⚠ May worsen insulin sensitivity at high doses
- ⚠ Possible HDL reduction
- ⚠ Fatty liver (in some rodent studies)
Известные взаимодействия
- ● Diabetes medications (may affect insulin sensitivity)
- ● Blood thinners (theoretical)
Допустимый верхний уровень потребления: 6 g/day; higher doses may worsen insulin sensitivity
Всегда консультируйтесь с врачом перед началом приёма любых добавок.Всегда консультируйтесь с лечащим врачом перед началом приёма любой добавки.
Frequently Asked Questions
Does CLA help with Obesity?
Based on 18 studies with 807 participants, there is moderate evidence from clinical studies that CLA may support Obesity management. Our evidence grade is B (Good Evidence).
How much CLA should I take for Obesity?
Studies have used various dosages. A commonly studied range is 3.2-6.4 g/day mixed isomers. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of CLA?
Reported side effects may include GI discomfort, May worsen insulin sensitivity at high doses, Possible HDL reduction, Fatty liver (in some rodent studies). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for CLA and Obesity?
We rate the evidence as Grade B (Good Evidence). This rating is based on 18 peer-reviewed studies with 807 total participants. The overall direction of effect is positive.
Related Evidence
Другие ингредиенты для Obesity
References
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- [12] Guoyao Wu et al.. Adv Exp Med Biol. 2021. Role of L-Arginine in Nitric Oxide Synthesis and Health in Humans. doi:10.1007/978-3-030-74180-8_10 PubMed
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