Alpha-Lipoic Acid untuk Obesity

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Meta-analysis of 12 RCTs (n=534) found significant weight loss of 1.27 kg and BMI reduction of 0.43. A 20-week RCT (n=360) found 1,800 mg/day reduced body weight by 2.1%. Higher doses and longer durations showed greater effects.

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Kesimpulan

Key Study Findings

Other

Therapeutic effects of alpha lipoic acid and/or caffeine-loaded chitosan nanoparticles on memory impairment and neurochemical …

Dose: None vs: None Outcome: Cognitive function Efek: None None

Populasi: Rat model

In Vitro

α-Lipoic acid attenuates obesity-associated hippocampal neuroinflammation and increases the levels of brain-derived neurotrophic factor in …

Dose: None vs: Ovariectomized rats on high-fat diet without alpha-LA Outcome: Hippocampal neuroinflammation and BDNF levels Efek: None None

Populasi: Ovariectomized rats fed high-fat diet

Key Statistics

Studi

534

Peserta

↑

Positive

Peringkat

Referenced Papers

Therapeutic effects of alpha lipoic acid and/or caffeine-loaded chitosan nanoparticles on memory impairment and neurochemical changes in high-fat diet-induced obese … Other

Physiology & behavior 2024 3 sitasi

α-Lipoic acid attenuates obesity-associated hippocampal neuroinflammation and increases the levels of brain-derived neurotrophic factor in ovariectomized rats fed a high-fat … Other

International journal of … 2013 29 sitasi

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Dosis yang Umum Digunakan

general:: 300-600 mg/day
ralaactiveform:: 150-300 mg/day
weightmanagement:: 600-1,800 mg/day

Batas atas: 1,800 mg/day; GI side effects at higher doses

Dosis yang Diteliti dalam Penelitian

Dosis	Durasi	Efek	N
None	--	Positive	--
None	--	Positive	--

Waktu terbaik diminum: 30 minutes before meals on empty stomach (food reduces absorption by ~30%)

Safety & Side Effects

Efek Samping yang Dilaporkan

⚠ Nausea
⚠ Skin rash
⚠ Hypoglycemia (when combined with diabetes medications)
⚠ GI discomfort

Interaksi yang Diketahui

● Diabetes medications (may potentiate — hypoglycemia risk)
● Thyroid medications (may affect thyroid hormone levels)
● Chemotherapy agents (antioxidant interaction)

Asupan atas yang dapat ditoleransi: 1,800 mg/day; GI side effects at higher doses

Selalu konsultasikan dengan tenaga kesehatan Anda sebelum memulai suplemen apa pun.Selalu konsultasikan dengan penyedia layanan kesehatan Anda sebelum memulai suplemen apa pun.

Frequently Asked Questions

Does Alpha-Lipoic Acid help with Obesity?

Based on 12 studies with 534 participants, there is moderate evidence from clinical studies that Alpha-Lipoic Acid may support Obesity management. Our evidence grade is B (Good Evidence).

How much Alpha-Lipoic Acid should I take for Obesity?

Studies have used various dosages. A commonly studied range is 300-600 mg/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Alpha-Lipoic Acid?

Reported side effects may include Nausea, Skin rash, Hypoglycemia (when combined with diabetes medications), GI discomfort. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Alpha-Lipoic Acid and Obesity?

We rate the evidence as Grade B (Good Evidence). This rating is based on 12 peer-reviewed studies with 534 total participants. The overall direction of effect is positive.

Bahan lain untuk Obesity

Glucomannan A CLA B Green Tea Extract (EGCG) B Vitamin D B Prebiotics/Inulin C Probiotics (Lactobacillus gasseri) C

Alpha-Lipoic Acid untuk kondisi lain

Insulin Resistance B

Kesimpulan Singkat

Meta-analysis of 12 RCTs (n=534) found significant weight loss of 1.27 kg and BMI reduction of 0.43. A 20-week RCT (n=360) found 1,800 mg/day reduced body weight by 2.1%. Higher …

Evidence Strength72%

High confidence

Rincian Studi

RCT (0)Meta (0)Other (12)

Bandingkan Alternatif

Lihat bagaimana bahan lain dibandingkan untuk kondisi ini.

Lihat semua bahan untuk Obesity

Pelajari Lebih Lanjut

References

[1] Eman N Hosny et al.. Physiol Behav. 2024. Therapeutic effects of alpha lipoic acid and/or caffeine-loaded chitosan nanoparticles on memory impairment and neurochemical changes in high-fat diet-induced obese … doi:10.1016/j.physbeh.2024.114697 PubMed
[2] Yulian Miao et al.. Int J Mol Med. 2013. α-Lipoic acid attenuates obesity-associated hippocampal neuroinflammation and increases the levels of brain-derived neurotrophic factor in ovariectomized rats fed a high-fat … doi:10.3892/ijmm.2013.1482 PubMed

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