What is the recommended dosage for Synephrine?

General: 10-20 mg p-synephrine 1-3x/day; Pre Exercise: 50 mg 45 min before; Weight Management: 25-50 mg/day

What are the side effects of Synephrine?

Potential side effects include: Mild increase in heart rate (at high doses), Headache, GI discomfort.

What is synephrine and how may it support weight management?

Synephrine is an alkaloid found in bitter orange (Citrus aurantium) that acts on adrenergic receptors. Some studies suggest it may increase resting metabolic rate and fat oxidation. It became popular as an alternative after ephedra was banned by the FDA in 2004.

What dosage of synephrine has been studied in clinical trials?

Clinical trials have typically studied synephrine at 10–50 mg per day, often as p-synephrine from bitter orange extract. Most studies lasted 6–12 weeks. Higher doses have not been adequately studied for long-term safety.

What are the potential side effects of synephrine?

Synephrine may increase blood pressure and heart rate, especially when combined with caffeine. Adverse event reports include chest pain, tachycardia, and cardiovascular events, though causality is not always established. It should be avoided by individuals with heart conditions or hypertension.

Synephrine

thermogenic

Also known as: p-Synephrine, Citrus aurantium Extract, Bitter Orange Extract

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About

A naturally occurring alkaloid from bitter orange peel that selectively activates beta-3 adrenergic receptors. Synephrine supports metabolic rate and fat oxidation without the significant cardiovascular stimulation associated with ephedrine-type compounds.

How It Works

Selective beta-3 adrenergic receptor agonist that stimulates lipolysis and thermogenesis without significantly activating beta-1 or beta-2 receptors (unlike ephedrine). Increases resting metabolic rate and fat oxidation while showing minimal cardiovascular stimulation at recommended doses.

Evidence For Conditions

Condition	Grade	Studies	Participants
Fat Oxidation Enhancement	B	20	1000	View →

Side Effects

Mild increase in heart rate (at high doses)
Headache
GI discomfort

Drug & Supplement Interactions

MAOIs
Other stimulants (avoid combination)
Caffeine (theoretical cardiovascular interaction)

Always inform your healthcare provider about all supplements you take.

Related Ingredients

Caffeine Capsaicin Forskolin Green Tea Extract (EGCG)

Quick Facts

Dosage: General: 10-20 mg p-synephrine 1-3x/day; Pre_Exercise: 50 mg 45 min before; Weight_Management: 25-50 mg/day
Forms: capsule tablet extract
Natural Sources: Bitter orange (Citrus aurantium) peel
Upper Limit: 100 mg/day; avoid combination with other stimulants
Best Time: 30-45 minutes before meals or exercise

Evidence Summary

Fat Oxidation Enhancement B

FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.