Caffeine ： Fat Oxidation Enhancement

Q: Does Caffeine help with Fat Oxidation Enhancement?

Based on 13 studies with 606 participants, there is strong evidence from multiple clinical trials that Caffeine may support Fat Oxidation Enhancement management. Our evidence grade is A (Strong Evidence).

Q: How much Caffeine should I take for Fat Oxidation Enhancement?

Studies have used various dosages. A commonly studied range is 100-200 mg/day. Always consult your healthcare provider before starting any supplement regimen.

Q: Are there side effects of Caffeine?

Reported side effects may include Insomnia, Anxiety and jitteriness, Increased heart rate, Digestive upset. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

Q: How strong is the evidence for Caffeine and Fat Oxidation Enhancement?

We rate the evidence as Grade A (Strong Evidence). This rating is based on 13 peer-reviewed studies with 606 total participants. The overall direction of effect is positive.

A エビデンス複数の大規模臨床試験が一貫して有意な効果を示しています。

Meta-analysis of 13 RCTs (n=606) found caffeine significantly increases resting metabolic rate by 3-11% and fat oxidation. A 100 mg/day increase in caffeine intake was associated with 0.11 kg less weight gain per 4-year period in two large prospective cohorts.

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結論

Key Study Findings

genome-wide association study n=312935

Genome wide association study of a Circadian Imbalance Index in 312,935 European ancestry UK Biobank …

Dose: None vs: Placebo 効果: None None

Other

Dietary vitamin B6 supplementation alleviates heat stress-induced intestinal barrier impairment by regulating the gut microbiota …

Dose: 34 g vs: None Outcome: Body weight 効果: None P < 0.05

対象集団: Rat model

Other

Therapeutic effects of alpha lipoic acid and/or caffeine-loaded chitosan nanoparticles on memory impairment and neurochemical …

Dose: None vs: None Outcome: Cognitive function 効果: None None

対象集団: Rat model

In Vitro

Niacin supplementation impairs exercise performance.

Dose: 5 mg/kg vs: placebo Outcome: lipid levels 効果: None p=0.02

対象集団: None

Randomized Controlled Trial n=61 36 weeks Double-blind

Multinutrient supplement containing ephedra and caffeine causes weight loss and improves metabolic risk factors in …

Dose: 40 mg/day ephedra alkaloids + 100 mg/day caffeine + vitamins/minerals/omega-3 vs: Placebo 効果: Treatment group lost -7.18 kg vs -2.25 kg in control

Review

Herbs and nutrients in the treatment of depression, anxiety, insomnia, migraine, and obesity.

Dose: None vs: Placebo 効果: None None

Key Statistics

研究数

606

参加者数

↑

Positive

グレード

Referenced Papers

Coffee consumption and its association with vitamin D level, lifestyle factors, and mental health symptoms among adults in Saudi Arabia. Other

The Journal of … 2026

Genome wide association study of a Circadian Imbalance Index in 312,935 European ancestry UK Biobank participants identifies loci related to … Other

Research square 2025

Dietary vitamin B6 supplementation alleviates heat stress-induced intestinal barrier impairment by regulating the gut microbiota and metabolites in broilers. Other

Poultry science 2024 12 件の引用

Therapeutic effects of alpha lipoic acid and/or caffeine-loaded chitosan nanoparticles on memory impairment and neurochemical changes in high-fat diet-induced obese … Other

Physiology & behavior 2024 3 件の引用

Niacin supplementation impairs exercise performance. Other

International journal for … 2023 1 件の引用

Multinutrient supplement containing ephedra and caffeine causes weight loss and improves metabolic risk factors in obese women: a randomized controlled … RCT

International journal of … 2006 85 件の引用

Herbs and nutrients in the treatment of depression, anxiety, insomnia, migraine, and obesity. Other

Journal of psychiatric … 2001 42 件の引用

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

一般的な使用量

general:: 100-200 mg/day
thermogenic:: 200-400 mg/day
preexercise:: 3-6 mg/kg body weight

上限量： 400 mg/day (FDA general guideline for healthy adults)

研究で検討された用量

用量	期間	効果	N
None	--	Mixed	312935
34 g	--	Positive	--
None	--	Positive	--
5 mg/kg	--	Neutral	--
40 mg/day ephedra alkaloids + 100 mg/day caffeine + vitamins/minerals/omega-3	36 weeks	Positive	61
None	--	Positive	--

推奨摂取タイミング： Morning or pre-exercise; avoid within 6 hours of bedtime; tolerance develops over 1-2 weeks

Safety & Side Effects

報告されている副作用

⚠ Insomnia
⚠ Anxiety and jitteriness
⚠ Increased heart rate
⚠ Digestive upset
⚠ Tolerance development over 1-2 weeks

既知の相互作用

● Adenosine receptor agonists
● Lithium (reduced clearance)
● Theophylline
● MAOIs
● Other stimulants (additive effects)

耐容上限摂取量： 400 mg/day (FDA general guideline for healthy adults)

サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。

Frequently Asked Questions

Does Caffeine help with Fat Oxidation Enhancement?

Based on 13 studies with 606 participants, there is strong evidence from multiple clinical trials that Caffeine may support Fat Oxidation Enhancement management. Our evidence grade is A (Strong Evidence).

How much Caffeine should I take for Fat Oxidation Enhancement?

Studies have used various dosages. A commonly studied range is 100-200 mg/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Caffeine?

Reported side effects may include Insomnia, Anxiety and jitteriness, Increased heart rate, Digestive upset. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Caffeine and Fat Oxidation Enhancement?

We rate the evidence as Grade A (Strong Evidence). This rating is based on 13 peer-reviewed studies with 606 total participants. The overall direction of effect is positive.

に関する他の成分： Fat Oxidation Enhancement

L-Carnitine B Synephrine B Capsaicin B

Caffeine 他の症状・状態について

Exercise Performance for Weight Loss A Weight Loss Plateau C

総合評価

Evidence Strength92%

High confidence

研究の内訳

RCT (1)Meta (0)Other (12)

代替成分との比較

この症状に対する他の成分との比較をご覧ください。

に関するすべての成分を見る： Fat Oxidation Enhancement

詳しく見る

References

[1] Noor A Hakim. J Steroid Biochem Mol Biol. 2026. Coffee consumption and its association with vitamin D level, lifestyle factors, and mental health symptoms among adults in Saudi Arabia. doi:10.1016/j.jsbmb.2025.106923 PubMed
[2] Magdalena Żebrowska et al.. Res Sq. 2025. Genome wide association study of a Circadian Imbalance Index in 312,935 European ancestry UK Biobank participants identifies loci related to … doi:10.21203/rs.3.rs-8329341/v1 PubMed
[3] Jingxin Ouyang et al.. Poult Sci. 2024. Dietary vitamin B6 supplementation alleviates heat stress-induced intestinal barrier impairment by regulating the gut microbiota and metabolites in broilers. doi:10.1016/j.psj.2024.104202 PubMed
[4] Eman N Hosny et al.. Physiol Behav. 2024. Therapeutic effects of alpha lipoic acid and/or caffeine-loaded chitosan nanoparticles on memory impairment and neurochemical changes in high-fat diet-induced obese … doi:10.1016/j.physbeh.2024.114697 PubMed
[5] Greggory R Davis et al.. Int J Vitam Nutr Res. 2023. Niacin supplementation impairs exercise performance. doi:10.1024/0300-9831/a000736 PubMed
[6] R M Hackman et al.. Int J Obes (Lond). 2006. Multinutrient supplement containing ephedra and caffeine causes weight loss and improves metabolic risk factors in obese women: a randomized controlled … doi:10.1038/sj.ijo.0803283 PubMed
[7] R P Brown et al.. J Psychiatr Pract. 2001. Herbs and nutrients in the treatment of depression, anxiety, insomnia, migraine, and obesity. doi:10.1097/00131746-200103000-00002 PubMed

FDAに関する免責事項: これらの記述は米国食品医薬品局（FDA）による評価を受けていません。本ウェブサイトの製品および情報は、疾病の診断、治療、治癒、または予防を目的としたものではありません。表示されているエビデンスグレードは、公開された査読済み研究の分析に基づいており、医療上の助言を構成するものではありません。サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。