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Vitamin D ： PCOS-Related Weight Management

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Meta-analysis found vitamin D supplementation in PCOS patients with deficiency significantly improved insulin resistance (HOMA-IR), testosterone levels, and metabolic parameters. Sixty to 80% of women with PCOS are vitamin D deficient. Correction supports hormonal balance.

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            B

        

        

            
結論

            
            
Meta-analysis found vitamin D supplementation in PCOS patients with deficiency significantly improved insulin resistance (HOMA-IR), testosterone levels, and metabolic parameters. Sixty to 80% of women with PCOS are vitamin D deficient. Correction supports hormonal balance.

            
            
        

    










    

  
Key Study Findings





    

        
        

            

                
                    Randomized Controlled Trial
                
                
                n=30
                
                
                
                Open-label
                
            

            
                Differential Impact of Insulin Sensitizers vs. Anti-Androgen on Serum Leptin Levels in Vitamin D Replete …
            
            

                
                Dose: 50 mg/d
                
                
                vs: None
                
                
                Outcome: None
                
                
                効果: None
                
                
                p<0.05
                
            

            
            
対象集団: None

            
        

        
        

            

                
                    Systematic Review
                
                
                
                
            

            
                Female Pattern Hair Loss and Androgen Excess: A Report From the Multidisciplinary Androgen Excess and …
            
            

                
                Dose: minoxidil 5%
                
                
                vs: Placebo
                
                
                
                
            

            
        

        
    







    
    

        
        

            

  
Key Statistics





            


    

        
12

        
研究数

    

    

        
800

        
参加者数

    

    

        
            
            ↑
            
        
        
Positive

    

    

        B

        
グレード

    




        


        
        
        

            

  
Referenced Papers





            

                
                

                    

                        
                            Differential Impact of Insulin Sensitizers vs. Anti-Androgen on Serum Leptin Levels in Vitamin D Replete PCOS Women: A Six Month …
                        
                        
                            
                                RCT
                            
                            
                            
                        
                    

                    

                        Hormone and metabolic …
                        2020
                        
                        6 件の引用
                        
                    

                

                
                

                    

                        
                            Female Pattern Hair Loss and Androgen Excess: A Report From the Multidisciplinary Androgen Excess and PCOS Committee.
                        
                        
                            
                                Meta-Analysis
                            
                            
                            
                        
                    

                    

                        The Journal of …
                        2019
                        
                        101 件の引用
                        
                    

                

                
            

        

        

        
        
        

            

  
Dosage & Usage





            
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units


            
            

                
一般的な使用量

                

                    
                    

                        
general:

                        
600-800 IU/day

                    

                    
                    

                        
weightmanagement:

                        
2,000-4,000 IU/day (targeting 25(OH)D >30 ng/mL)

                    

                    
                    

                        
deficiencycorrection:

                        
5,000-10,000 IU/day for 8-12 weeks under medical supervision

                    

                    
                

                
                

                    上限量： 4,000 IU/day (100 mcg); higher doses under medical supervision
                

                
            

            

            
            

                
研究で検討された用量

                

                    

                        
                            

                                用量
                                期間
                                効果
                                N
                            

                        
                        
                            
                            

                                50 mg/d
                                --
                                
                                    
                                    Positive
                                    
                                
                                30
                            

                            
                            

                                minoxidil 5%
                                --
                                
                                    
                                    Positive
                                    
                                
                                --
                            

                            
                        
                    

                

            

            

            
            

                推奨摂取タイミング： With a meal containing fat for absorption; morning preferred
            

            
        

        

        
        
        

            

  
Safety & Side Effects





            

                
                

                    
報告されている副作用

                    
    
                        
                        
  • 
                            ⚠
                            Hypercalcemia (at very high doses)
                        
    • 
                        
                        
  • 
                            ⚠
                            Nausea
                        
    • 
                        
                        
  • 
                            ⚠
                            Kidney stones (at excessive doses)
                        
    • 
                        
                    

                

                

                
                

                    
既知の相互作用

                    
    
                        
                        
  • 
                            ●
                            Statins (may increase statin levels)
                        
    • 
                        
                        
  • 
                            ●
                            Thiazide diuretics (increased calcium risk)
                        
    • 
                        
                        
  • 
                            ●
                            Corticosteroids (impair vitamin D metabolism)
                        
    • 
                        
                        
  • 
                            ●
                            Orlistat (reduced absorption)
                        
    • 
                        
                    

                

                

                
                

                    

                        耐容上限摂取量： 4,000 IU/day (100 mcg); higher doses under medical supervision
                    

                

                
            

            

                サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。
            

        

        

        
        
        

            

  
Frequently Asked Questions





            




    
    

        
            Does Vitamin D help with PCOS-Related Weight Management?
            
        
        

            Based on 12 studies with 800 participants, there is moderate evidence from clinical studies that Vitamin D may support PCOS-Related Weight Management management. Our evidence grade is B (Good Evidence).
        

    

    
    

        
            How much Vitamin D should I take for PCOS-Related Weight Management?
            
        
        

            Studies have used various dosages. A commonly studied range is 600-800 IU/day. Always consult your healthcare provider before starting any supplement regimen.
        

    

    
    

        
            Are there side effects of Vitamin D?
            
        
        

            Reported side effects may include Hypercalcemia (at very high doses), Nausea, Kidney stones (at excessive doses). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
        

    

    
    

        
            How strong is the evidence for Vitamin D and PCOS-Related Weight Management?
            
        
        

            We rate the evidence as Grade B (Good Evidence). This rating is based on 12 peer-reviewed studies with 800 total participants. The overall direction of effect is positive.
        

    

    




        

        

        
        
        

            

  




            

                
                

                    
に関する他の成分： PCOS-Related Weight Management

                    

                        
                        
                            Berberine
                            C

                        
                        
                        
                            Chromium
                            C

                        
                        
                    

                

                

                
                

                    
Vitamin D 他の症状・状態について

                    

                        
                        
                            Obesity
                            B

                        
                        
                        
                            Menopause-Related Weight Gain
                            C

                        
                        
                    

                

                
            

        

        

    


    
    






  
References

  
    
    
    
  1. 
      [1]
      Aafia Rashid et al..
      Horm Metab Res.
      2020.
      Differential Impact of Insulin Sensitizers vs. Anti-Androgen on Serum Leptin Levels in Vitamin D Replete PCOS Women: A Six Month …
      doi:10.1055/a-1084-5441
      PubMed
    
    2. 
    
    
  2. 
      [2]
      Enrico Carmina et al..
      J Clin Endocrinol Metab.
      2019.
      Female Pattern Hair Loss and Androgen Excess: A Report From the Multidisciplinary Androgen Excess and PCOS Committee.
      doi:10.1210/jc.2018-02548
      PubMed
    
    3. 
    
  















    

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