Vitamin D ： Menopause-Related Weight Gain

C エビデンス小規模研究からのエビデンスは限られていますが、いくつかの肯定的なシグナルがあります。

Menopausal women are frequently vitamin D deficient. Supplementation may improve insulin sensitivity and body composition during the menopausal transition. A prospective study (n=4,659) found higher vitamin D associated with less weight gain. Benefits are primarily seen in deficient individuals.

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結論

Key Study Findings

narrative review

Addressing the Root Causes of Female Hair Loss and Non-Pharmaceutical Interventions.

Dose: None vs: Placebo 効果: None None

systematic review n=90

A systematic review on the impact of nutrition and possible supplementation on the deficiency of …

Dose: None vs: Placebo 効果: None None

Randomized Controlled Trial 48 weeks Double-blind

Regular Supplementation With Resveratrol Improves Bone Mineral Density in Postmenopausal Women: A Randomized, Placebo-Controlled Trial.

Dose: 75 mg vs: placebo Outcome: None 効果: None None

対象集団: rat

Review

[Lactose intolerance: past and present. Part II].

Dose: 750 mg vs: None Outcome: None 効果: None None

対象集団: postmenopausal women

randomized_controlled_trial n=634 12 weeks

Randomized controlled study on clinical efficacy of isoflavones plus Lactobacillus sporogenes, associated or not with …

Dose: ES: magnolia bark extract + isoflavones 60 mg + Lactobacillus sporogenes + calcium + vitamin D3 (1 t vs: Placebo 効果: ES significantly more active on insomnia, irritability, anxiety, depressed mood, asthenia, loss of l not_reported

randomized controlled trial n=89 24 weeks Open-label

Soy isoflavones, lactobacilli, Magnolia bark extract, vitamin D3 and calcium. Controlled clinical study in menopause.

Dose: 1 tablet/day: soy isoflavones 60mg + lactobacilli 500M spores + calcium 141mg + vitamin D3 5mcg + Ma vs: Placebo 効果: Significantly reduced severity/frequency of all symptoms vs Ca+D; wellbeing good/very good 66.7% vs None

Key Statistics

研究数

500

参加者数

↑

Positive

グレード

Referenced Papers

Addressing the Root Causes of Female Hair Loss and Non-Pharmaceutical Interventions. Review

Journal of drugs … 2025

A systematic review on the impact of nutrition and possible supplementation on the deficiency of vitamin complexes, iron, omega-3-fatty acids, … Systematic Review

Archives of gynecology … 2024 18 件の引用

Regular Supplementation With Resveratrol Improves Bone Mineral Density in Postmenopausal Women: A Randomized, Placebo-Controlled Trial. RCT

Journal of bone … 2020 120 件の引用

Effects of a phyto complex on well-being of climacteric women. Observational

The journal of … 2015 13 件の引用

[Lactose intolerance: past and present. Part II]. Review

Orvosi hetilap 2015 4 件の引用

Bone mineral density in patients with alopecia areata treated with long-term intralesional corticosteroids. Other

Journal of drugs … 2013

Randomized controlled study on clinical efficacy of isoflavones plus Lactobacillus sporogenes, associated or not with a natural anxiolytic agent in … RCT

Minerva ginecologica 2011 19 件の引用

Multivitamin/mineral supplements and prevention of chronic disease. Review

Evidence report/technology assessment 2006

Soy isoflavones, lactobacilli, Magnolia bark extract, vitamin D3 and calcium. Controlled clinical study in menopause. RCT

Minerva ginecologica 2006

Exercise effects on menopausal risk factors of early postmenopausal women: 3-yr Erlangen fitness osteoporosis prevention study results. Other

Medicine and science … 2005

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

一般的な使用量

general:: 600-800 IU/day
weightmanagement:: 2,000-4,000 IU/day (targeting 25(OH)D >30 ng/mL)
deficiencycorrection:: 5,000-10,000 IU/day for 8-12 weeks under medical supervision

上限量： 4,000 IU/day (100 mcg); higher doses under medical supervision

研究で検討された用量

用量	期間	効果	N
None	--	Positive	--
None	--	Negative	90
75 mg	48 weeks	Positive	--
750 mg	--	Positive	--
ES: magnolia bark extract + isoflavones 60 mg + Lactobacillus sporogenes + calcium + vitamin D3 (1 t	12 weeks	Positive	634
1 tablet/day: soy isoflavones 60mg + lactobacilli 500M spores + calcium 141mg + vitamin D3 5mcg + Ma	24 weeks	Positive	89
Multivitamin/mineral supplements	--	Mixed	--

推奨摂取タイミング： With a meal containing fat for absorption; morning preferred

Safety & Side Effects

報告されている副作用

⚠ Hypercalcemia (at very high doses)
⚠ Nausea
⚠ Kidney stones (at excessive doses)

既知の相互作用

● Statins (may increase statin levels)
● Thiazide diuretics (increased calcium risk)
● Corticosteroids (impair vitamin D metabolism)
● Orlistat (reduced absorption)

耐容上限摂取量： 4,000 IU/day (100 mcg); higher doses under medical supervision

サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。

Frequently Asked Questions

Does Vitamin D help with Menopause-Related Weight Gain?

Based on 6 studies with 500 participants, there is limited but promising evidence that Vitamin D may support Menopause-Related Weight Gain management. Our evidence grade is C (Some Evidence).

How much Vitamin D should I take for Menopause-Related Weight Gain?

Studies have used various dosages. A commonly studied range is 600-800 IU/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Vitamin D?

Reported side effects may include Hypercalcemia (at very high doses), Nausea, Kidney stones (at excessive doses). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Vitamin D and Menopause-Related Weight Gain?

We rate the evidence as Grade C (Some Evidence). This rating is based on 6 peer-reviewed studies with 500 total participants. The overall direction of effect is positive.

に関する他の成分： Menopause-Related Weight Gain

Maca C

Vitamin D 他の症状・状態について

PCOS-Related Weight Management B Obesity B

総合評価

Evidence Strength52%

Moderate confidence

研究の内訳

RCT (3)Meta (0)Other (3)

代替成分との比較

この症状に対する他の成分との比較をご覧ください。

に関するすべての成分を見る： Menopause-Related Weight Gain

詳しく見る

References

[1] Adam Leavitt et al.. J Drugs Dermatol. 2025. Addressing the Root Causes of Female Hair Loss and Non-Pharmaceutical Interventions. doi:10.36849/JDD.8763 PubMed
[2] Friederike Wylenzek et al.. Arch Gynecol Obstet. 2024. A systematic review on the impact of nutrition and possible supplementation on the deficiency of vitamin complexes, iron, omega-3-fatty acids, … doi:10.1007/s00404-024-07555-6 PubMed
[3] Rachel Hx Wong et al.. J Bone Miner Res. 2020. Regular Supplementation With Resveratrol Improves Bone Mineral Density in Postmenopausal Women: A Randomized, Placebo-Controlled Trial. doi:10.1002/jbmr.4115 PubMed
[4] Tomasella Quattrocchi et al.. J Obstet Gynaecol Res. 2015. Effects of a phyto complex on well-being of climacteric women. doi:10.1111/jog.12659 PubMed
[5] György Miklós Buzás. Orv Hetil. 2015. [Lactose intolerance: past and present. Part II]. doi:10.1556/650.2015.30280 PubMed
[6] Aman Samrao et al.. J Drugs Dermatol. 2013. Bone mineral density in patients with alopecia areata treated with long-term intralesional corticosteroids. PubMed
[7] C Agosta et al.. Minerva Ginecol. 2011. Randomized controlled study on clinical efficacy of isoflavones plus Lactobacillus sporogenes, associated or not with a natural anxiolytic agent in … PubMed
[8] Han-Yo Huang et al.. Evid Rep Technol Assess (Full Rep). 2006. Multivitamin/mineral supplements and prevention of chronic disease. PubMed
[9] M Mucci et al.. Minerva Ginecol. 2006. Soy isoflavones, lactobacilli, Magnolia bark extract, vitamin D3 and calcium. Controlled clinical study in menopause. PubMed
[10] Wolfgang Kemmler et al.. Med Sci Sports Exerc. 2005. Exercise effects on menopausal risk factors of early postmenopausal women: 3-yr Erlangen fitness osteoporosis prevention study results. doi:10.1249/01.mss.0000152678.20239.76 PubMed

FDAに関する免責事項: これらの記述は米国食品医薬品局（FDA）による評価を受けていません。本ウェブサイトの製品および情報は、疾病の診断、治療、治癒、または予防を目的としたものではありません。表示されているエビデンスグレードは、公開された査読済み研究の分析に基づいており、医療上の助言を構成するものではありません。サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。