Zinc ： Insulin Resistance

Q: Does Zinc help with Insulin Resistance?

Based on 27 studies with 1,652 participants, there is moderate evidence from clinical studies that Zinc may support Insulin Resistance management. Our evidence grade is B (Good Evidence).

Q: How much Zinc should I take for Insulin Resistance?

Studies have used various dosages. A commonly studied range is 8-11 mg/day (RDA). Always consult your healthcare provider before starting any supplement regimen.

Q: Are there side effects of Zinc?

Reported side effects may include Nausea, Vomiting (on empty stomach), Copper depletion (long-term high dose), Metallic taste. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

Q: How strong is the evidence for Zinc and Insulin Resistance?

We rate the evidence as Grade B (Good Evidence). This rating is based on 27 peer-reviewed studies with 1,652 total participants. The overall direction of effect is positive.

B エビデンス少なくとも1件のランダム化試験がこれを支持しており、おおむね一貫した結果が得られています。

Meta-analysis of 27 RCTs (n=1,652) found zinc supplementation significantly reduced body weight (0.63 kg), BMI, waist circumference, and HOMA-IR. Separate meta-analysis found significant reductions in fasting glucose, HbA1c, and insulin. Effects are strongest in deficient and obese individuals.

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結論

Key Study Findings

Review

A review on linking stress, depression, and insulin resistance via low-grade chronic inflammation.

Dose: None vs: None Outcome: Chronic inflammation linking stress, depression, IR 効果: None None

対象集団: Review of metabolic syndrome and depression

Meta-Analysis

Comparative effects of vitamin and mineral supplements in the management of type 2 diabetes in …

Dose: Various vitamins and minerals vs: Placebo or standard care Outcome: Glycemic control and lipid metabolism 効果: None None

対象集団: T2DM patients in primary care (RCTs)

Review

Consequences of Disturbing Manganese Homeostasis.

Dose: Manganese (Mn) - exposure assessment vs: None Outcome: Mn toxicity mechanisms on CNS 効果: None None

対象集団: General (manganese exposure review)

Controlled Clinical Trial n=77

Hypoglycemic and Hypolipidemic Effects of Leucine, Zinc, and Chromium, Alone and in Combination, in Rats …

Dose: leucine, zinc, and chromium alone/combined vs: vehicle-treated T2D rats Outcome: blood glucose and serum lipid profile 効果: None <0.05

対象集団: Male Wistar rats with type 2 diabetes

Controlled Clinical Trial

[Nutrition and fertility].

Dose: None vs: None Outcome: insulin resistance 効果: None None

対象集団: overweight individuals

Key Statistics

研究数

1652

参加者数

↑

Positive

グレード

Referenced Papers

Consequences of Disturbing Manganese Homeostasis. Review

International journal of … 2023 120 件の引用

A review on linking stress, depression, and insulin resistance via low-grade chronic inflammation. Review

Biochemistry and biophysics … 2023 66 件の引用

Comparative effects of vitamin and mineral supplements in the management of type 2 diabetes in primary care: A systematic review … Meta-Analysis

Pharmacological research 2023 29 件の引用

Hypoglycemic and Hypolipidemic Effects of Leucine, Zinc, and Chromium, Alone and in Combination, in Rats with Type 2 Diabetes. Other

Biological trace element … 2017 35 件の引用

[Nutrition and fertility]. Other

Medycyna wieku rozwojowego 2011

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

一般的な使用量

general:: 8-11 mg/day (RDA)
postbariatric:: 16-22 mg/day
metabolicsupport:: 15-30 mg/day

上限量： 40 mg/day (long-term); higher doses may cause copper depletion

研究で検討された用量

用量	期間	効果	N
None	--	Neutral	--
Various vitamins and minerals	--	Positive	--
Manganese (Mn) - exposure assessment	--	Negative	--
leucine, zinc, and chromium alone/combined	--	Positive	77
None	--	Positive	--

推奨摂取タイミング： With meals to minimize nausea; avoid taking with iron or calcium simultaneously

Safety & Side Effects

報告されている副作用

⚠ Nausea
⚠ Vomiting (on empty stomach)
⚠ Copper depletion (long-term high dose)
⚠ Metallic taste

既知の相互作用

● Antibiotics (reduced absorption — take 2 hours apart)
● Penicillamine (reduced absorption)
● Iron supplements (competitive absorption)
● Calcium supplements (competitive absorption)

耐容上限摂取量： 40 mg/day (long-term); higher doses may cause copper depletion

サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。

Frequently Asked Questions

Does Zinc help with Insulin Resistance?

Based on 27 studies with 1,652 participants, there is moderate evidence from clinical studies that Zinc may support Insulin Resistance management. Our evidence grade is B (Good Evidence).

How much Zinc should I take for Insulin Resistance?

Studies have used various dosages. A commonly studied range is 8-11 mg/day (RDA). Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Zinc?

Reported side effects may include Nausea, Vomiting (on empty stomach), Copper depletion (long-term high dose), Metallic taste. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Zinc and Insulin Resistance?

We rate the evidence as Grade B (Good Evidence). This rating is based on 27 peer-reviewed studies with 1,652 total participants. The overall direction of effect is positive.

に関する他の成分： Insulin Resistance

Berberine A Magnesium B Chromium B Alpha-Lipoic Acid B Ginger C Apple Cider Vinegar C

総合評価

Evidence Strength72%

High confidence

研究の内訳

RCT (0)Meta (1)Other (26)

代替成分との比較

この症状に対する他の成分との比較をご覧ください。

に関するすべての成分を見る： Insulin Resistance

詳しく見る

References

[1] Jacek Baj et al.. Int J Mol Sci. 2023. Consequences of Disturbing Manganese Homeostasis. doi:10.3390/ijms241914959 PubMed
[2] Seema Mehdi et al.. Biochem Biophys Rep. 2023. A review on linking stress, depression, and insulin resistance via low-grade chronic inflammation. doi:10.1016/j.bbrep.2023.101571 PubMed
[3] Jiayue Xia et al.. Pharmacol Res. 2023. Comparative effects of vitamin and mineral supplements in the management of type 2 diabetes in primary care: A systematic review … doi:10.1016/j.phrs.2023.106647 PubMed
[4] Hassan Sadri et al.. Biol Trace Elem Res. 2017. Hypoglycemic and Hypolipidemic Effects of Leucine, Zinc, and Chromium, Alone and in Combination, in Rats with Type 2 Diabetes. doi:10.1007/s12011-017-1014-2 PubMed
[5] Dorota Szostak-Węgierek. Med Wieku Rozwoj. 2011. [Nutrition and fertility]. PubMed

FDAに関する免責事項: これらの記述は米国食品医薬品局（FDA）による評価を受けていません。本ウェブサイトの製品および情報は、疾病の診断、治療、治癒、または予防を目的としたものではありません。表示されているエビデンスグレードは、公開された査読済み研究の分析に基づいており、医療上の助言を構成するものではありません。サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。