Vitamin D 用于更年期相关体重增加

C 证据来自小型研究的证据有限，但存在一些积极信号。

Menopausal women are frequently vitamin D deficient. Supplementation may improve insulin sensitivity and body composition during the menopausal transition. A prospective study (n=4,659) found higher vitamin D associated with less weight gain. Benefits are primarily seen in deficient individuals.

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结论

Key Study Findings

narrative review

Addressing the Root Causes of Female Hair Loss and Non-Pharmaceutical Interventions.

Dose: None vs: Placebo 效果: None None

systematic review n=90

A systematic review on the impact of nutrition and possible supplementation on the deficiency of …

Dose: None vs: Placebo 效果: None None

Randomized Controlled Trial 48 weeks Double-blind

Regular Supplementation With Resveratrol Improves Bone Mineral Density in Postmenopausal Women: A Randomized, Placebo-Controlled Trial.

Dose: 75 mg vs: placebo Outcome: None 效果: None None

研究人群: rat

Review

[Lactose intolerance: past and present. Part II].

Dose: 750 mg vs: None Outcome: None 效果: None None

研究人群: postmenopausal women

randomized_controlled_trial n=634 12 weeks

Randomized controlled study on clinical efficacy of isoflavones plus Lactobacillus sporogenes, associated or not with …

Dose: ES: magnolia bark extract + isoflavones 60 mg + Lactobacillus sporogenes + calcium + vitamin D3 (1 t vs: Placebo 效果: ES significantly more active on insomnia, irritability, anxiety, depressed mood, asthenia, loss of l not_reported

randomized controlled trial n=89 24 weeks Open-label

Soy isoflavones, lactobacilli, Magnolia bark extract, vitamin D3 and calcium. Controlled clinical study in menopause.

Dose: 1 tablet/day: soy isoflavones 60mg + lactobacilli 500M spores + calcium 141mg + vitamin D3 5mcg + Ma vs: Placebo 效果: Significantly reduced severity/frequency of all symptoms vs Ca+D; wellbeing good/very good 66.7% vs None

Key Statistics

研究数量

500

受试者

↑

Positive

等级

Referenced Papers

Addressing the Root Causes of Female Hair Loss and Non-Pharmaceutical Interventions. Review

Journal of drugs … 2025

A systematic review on the impact of nutrition and possible supplementation on the deficiency of vitamin complexes, iron, omega-3-fatty acids, … Systematic Review

Archives of gynecology … 2024 18 次引用

Regular Supplementation With Resveratrol Improves Bone Mineral Density in Postmenopausal Women: A Randomized, Placebo-Controlled Trial. RCT

Journal of bone … 2020 120 次引用

Effects of a phyto complex on well-being of climacteric women. Observational

The journal of … 2015 13 次引用

[Lactose intolerance: past and present. Part II]. Review

Orvosi hetilap 2015 4 次引用

Bone mineral density in patients with alopecia areata treated with long-term intralesional corticosteroids. Other

Journal of drugs … 2013

Randomized controlled study on clinical efficacy of isoflavones plus Lactobacillus sporogenes, associated or not with a natural anxiolytic agent in … RCT

Minerva ginecologica 2011 19 次引用

Multivitamin/mineral supplements and prevention of chronic disease. Review

Evidence report/technology assessment 2006

Soy isoflavones, lactobacilli, Magnolia bark extract, vitamin D3 and calcium. Controlled clinical study in menopause. RCT

Minerva ginecologica 2006

Exercise effects on menopausal risk factors of early postmenopausal women: 3-yr Erlangen fitness osteoporosis prevention study results. Other

Medicine and science … 2005

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

常用剂量

general:: 600-800 IU/day
weightmanagement:: 2,000-4,000 IU/day (targeting 25(OH)D >30 ng/mL)
deficiencycorrection:: 5,000-10,000 IU/day for 8-12 weeks under medical supervision

上限： 4,000 IU/day (100 mcg); higher doses under medical supervision

研究中使用的剂量

剂量	持续时间	效果	N
None	--	Positive	--
None	--	Negative	90
75 mg	48 weeks	Positive	--
750 mg	--	Positive	--
ES: magnolia bark extract + isoflavones 60 mg + Lactobacillus sporogenes + calcium + vitamin D3 (1 t	12 weeks	Positive	634
1 tablet/day: soy isoflavones 60mg + lactobacilli 500M spores + calcium 141mg + vitamin D3 5mcg + Ma	24 weeks	Positive	89
Multivitamin/mineral supplements	--	Mixed	--

最佳服用时间： With a meal containing fat for absorption; morning preferred

Safety & Side Effects

已报告的副作用

⚠ Hypercalcemia (at very high doses)
⚠ Nausea
⚠ Kidney stones (at excessive doses)

已知相互作用

● Statins (may increase statin levels)
● Thiazide diuretics (increased calcium risk)
● Corticosteroids (impair vitamin D metabolism)
● Orlistat (reduced absorption)

可耐受最高摄入量： 4,000 IU/day (100 mcg); higher doses under medical supervision

在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。

Frequently Asked Questions

Does Vitamin D help with 更年期相关体重增加?

Based on 6 studies with 500 participants, there is limited but promising evidence that Vitamin D may support 更年期相关体重增加 management. Our evidence grade is C (Some Evidence).

How much Vitamin D should I take for 更年期相关体重增加?

Studies have used various dosages. A commonly studied range is 600-800 IU/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Vitamin D?

Reported side effects may include Hypercalcemia (at very high doses), Nausea, Kidney stones (at excessive doses). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Vitamin D and 更年期相关体重增加?

We rate the evidence as Grade C (Some Evidence). This rating is based on 6 peer-reviewed studies with 500 total participants. The overall direction of effect is positive.

其他成分用于更年期相关体重增加

Maca C

Vitamin D 用于其他健康状况

多囊卵巢综合征相关体重管理 B 肥胖症 B

快速结论

Evidence Strength52%

Moderate confidence

研究分析

RCT (3)Meta (0)Other (3)

对比替代方案

查看其他成分针对该健康状况的对比结果。

查看所有成分用于更年期相关体重增加

了解更多

References

[1] Adam Leavitt et al.. J Drugs Dermatol. 2025. Addressing the Root Causes of Female Hair Loss and Non-Pharmaceutical Interventions. doi:10.36849/JDD.8763 PubMed
[2] Friederike Wylenzek et al.. Arch Gynecol Obstet. 2024. A systematic review on the impact of nutrition and possible supplementation on the deficiency of vitamin complexes, iron, omega-3-fatty acids, … doi:10.1007/s00404-024-07555-6 PubMed
[3] Rachel Hx Wong et al.. J Bone Miner Res. 2020. Regular Supplementation With Resveratrol Improves Bone Mineral Density in Postmenopausal Women: A Randomized, Placebo-Controlled Trial. doi:10.1002/jbmr.4115 PubMed
[4] Tomasella Quattrocchi et al.. J Obstet Gynaecol Res. 2015. Effects of a phyto complex on well-being of climacteric women. doi:10.1111/jog.12659 PubMed
[5] György Miklós Buzás. Orv Hetil. 2015. [Lactose intolerance: past and present. Part II]. doi:10.1556/650.2015.30280 PubMed
[6] Aman Samrao et al.. J Drugs Dermatol. 2013. Bone mineral density in patients with alopecia areata treated with long-term intralesional corticosteroids. PubMed
[7] C Agosta et al.. Minerva Ginecol. 2011. Randomized controlled study on clinical efficacy of isoflavones plus Lactobacillus sporogenes, associated or not with a natural anxiolytic agent in … PubMed
[8] Han-Yo Huang et al.. Evid Rep Technol Assess (Full Rep). 2006. Multivitamin/mineral supplements and prevention of chronic disease. PubMed
[9] M Mucci et al.. Minerva Ginecol. 2006. Soy isoflavones, lactobacilli, Magnolia bark extract, vitamin D3 and calcium. Controlled clinical study in menopause. PubMed
[10] Wolfgang Kemmler et al.. Med Sci Sports Exerc. 2005. Exercise effects on menopausal risk factors of early postmenopausal women: 3-yr Erlangen fitness osteoporosis prevention study results. doi:10.1249/01.mss.0000152678.20239.76 PubMed

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