Zinc 用于 胰岛素抵抗
B 证据 至少一项随机试验支持这一结论,结果基本一致。Meta-analysis of 27 RCTs (n=1,652) found zinc supplementation significantly reduced body weight (0.63 kg), BMI, waist circumference, and HOMA-IR. Separate meta-analysis found significant reductions in fasting glucose, HbA1c, and insulin. Effects are strongest in deficient and obese individuals.
结论
Meta-analysis of 27 RCTs (n=1,652) found zinc supplementation significantly reduced body weight (0.63 kg), BMI, waist circumference, and HOMA-IR. Separate meta-analysis found significant reductions in fasting glucose, HbA1c, and insulin. Effects are strongest in deficient and obese individuals.
Key Study Findings
研究人群: Review of metabolic syndrome and depression
研究人群: T2DM patients in primary care (RCTs)
研究人群: General (manganese exposure review)
研究人群: Male Wistar rats with type 2 diabetes
研究人群: overweight individuals
Key Statistics
27
研究数量
1652
受试者
Positive
等级
Referenced Papers
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
常用剂量
- general:
- 8-11 mg/day (RDA)
- postbariatric:
- 16-22 mg/day
- metabolicsupport:
- 15-30 mg/day
上限: 40 mg/day (long-term); higher doses may cause copper depletion
研究中使用的剂量
| 剂量 | 持续时间 | 效果 | N |
|---|---|---|---|
| None | -- | Neutral | -- |
| Various vitamins and minerals | -- | Positive | -- |
| Manganese (Mn) - exposure assessment | -- | Negative | -- |
| leucine, zinc, and chromium alone/combined | -- | Positive | 77 |
| None | -- | Positive | -- |
最佳服用时间: With meals to minimize nausea; avoid taking with iron or calcium simultaneously
Safety & Side Effects
已报告的副作用
- ⚠ Nausea
- ⚠ Vomiting (on empty stomach)
- ⚠ Copper depletion (long-term high dose)
- ⚠ Metallic taste
已知相互作用
- ● Antibiotics (reduced absorption — take 2 hours apart)
- ● Penicillamine (reduced absorption)
- ● Iron supplements (competitive absorption)
- ● Calcium supplements (competitive absorption)
可耐受最高摄入量: 40 mg/day (long-term); higher doses may cause copper depletion
在开始服用任何补充剂之前,请务必咨询您的医疗保健提供者。
Frequently Asked Questions
Does Zinc help with 胰岛素抵抗?
How much Zinc should I take for 胰岛素抵抗?
Are there side effects of Zinc?
How strong is the evidence for Zinc and 胰岛素抵抗?
Related Evidence
References
- [1] Jacek Baj et al.. Int J Mol Sci. 2023. Consequences of Disturbing Manganese Homeostasis. doi:10.3390/ijms241914959 PubMed
- [2] Seema Mehdi et al.. Biochem Biophys Rep. 2023. A review on linking stress, depression, and insulin resistance via low-grade chronic inflammation. doi:10.1016/j.bbrep.2023.101571 PubMed
- [3] Jiayue Xia et al.. Pharmacol Res. 2023. Comparative effects of vitamin and mineral supplements in the management of type 2 diabetes in primary care: A systematic review … doi:10.1016/j.phrs.2023.106647 PubMed
- [4] Hassan Sadri et al.. Biol Trace Elem Res. 2017. Hypoglycemic and Hypolipidemic Effects of Leucine, Zinc, and Chromium, Alone and in Combination, in Rats with Type 2 Diabetes. doi:10.1007/s12011-017-1014-2 PubMed
- [5] Dorota Szostak-Węgierek. Med Wieku Rozwoj. 2011. [Nutrition and fertility]. PubMed
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