Alpha-Lipoic AcidAlpha-Lipoic Acid
fat_metabolism
别名: ALA, R-Lipoic Acid, R-ALA, Thioctic Acid
About
A uniquely versatile antioxidant that is both fat- and water-soluble, allowing it to function in all tissue compartments. Meta-analyses demonstrate alpha-lipoic acid may support healthy body weight and insulin sensitivity, particularly at higher doses over extended supplementation periods.
How It Works
Both fat- and water-soluble antioxidant that activates AMPK in the hypothalamus, reducing caloric intake, while simultaneously enhancing insulin-stimulated glucose uptake in peripheral tissues. Regenerates endogenous antioxidants (glutathione, vitamins C and E) and chelates transition metals, reducing oxidative stress that impairs metabolic signaling.
Evidence For Conditions
| 健康状况 | 等级 | 研究数量 | 受试者 | |
|---|---|---|---|---|
| Obesity | B | 12 | 534 | 查看 → |
| Insulin Resistance | B | 10 | 800 | 查看 → |
Side Effects
- Nausea
- Skin rash
- Hypoglycemia (when combined with diabetes medications)
- GI discomfort
Drug & Supplement Interactions
- Diabetes medications (may potentiate — hypoglycemia risk)
- Thyroid medications (may affect thyroid hormone levels)
- Chemotherapy agents (antioxidant interaction)
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Related Ingredients
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