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WeightCited

CLA
CLA

fat_metabolism

别名: Conjugated Linoleic Acid, Tonalin, Clarinol

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About





            

                
A group of naturally occurring fatty acid isomers found in ruminant animal products. Conjugated linoleic acid (CLA) modulates adipose tissue metabolism and may support favorable changes in body composition by reducing fat mass while preserving lean mass over long-term supplementation.

            

        

        

        
        
        

            

  
How It Works





            

                
A group of positional and geometric isomers of linoleic acid (primarily c9,t11 and t10,c12) that modulate adipose tissue metabolism. The t10,c12 isomer inhibits stearoyl-CoA desaturase and lipoprotein lipase, reducing fat storage. Also activates PPAR-gamma and AMPK, increasing fat oxidation in skeletal muscle while reducing adipocyte lipid accumulation.

            

        

        

        
        
        

            

  
Evidence For Conditions





            

                

                    

                        
                            

                                健康状况
                                等级
                                研究数量
                                受试者
                                
                            

                        
                        
                            
                            

                                
                                    
                                        Obesity
                                    
                                
                                
                                    B

                                
                                
                                    18
                                
                                
                                    807
                                
                                
                                    
                                        查看 →
                                    
                                
                            

                            
                        
                    

                

            

        

        

        
        
        

            

  
Side Effects





            
    
                
                
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                    GI discomfort
                
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                    May worsen insulin sensitivity at high doses
                
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                    Possible HDL reduction
                
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                    Fatty liver (in some rodent studies)
                
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Drug & Supplement Interactions





            
    
                
                
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                    Diabetes medications (may affect insulin sensitivity)
                
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                    Blood thinners (theoretical)
                
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Related Ingredients





            

                
                
                    L-Carnitine
                    
                
                
                
                    MCT Oil
                    
                
                
                
                    Berberine
                    
                
                
                
                    Alpha-Lipoic Acid
                    
                
                
            

        

        
    


    
    












    

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