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WeightCited

Zinc per Insulin Resistance

B

Meta-analysis of 27 RCTs (n=1,652) found zinc supplementation significantly reduced body weight (0.63 kg), BMI, waist circumference, and HOMA-IR. Separate meta-analysis found significant reductions in fasting glucose, HbA1c, and insulin. Effects are strongest in deficient and obese individuals.

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            B

        

        

            
In sintesi

            
            
Meta-analysis of 27 RCTs (n=1,652) found zinc supplementation significantly reduced body weight (0.63 kg), BMI, waist circumference, and HOMA-IR. Separate meta-analysis found significant reductions in fasting glucose, HbA1c, and insulin. Effects are strongest in deficient and obese individuals.

            
            
        

    











    
    

        
        

            

  
Key Statistics





            


    

        
27

        
Studi

    

    

        
1652

        
Partecipanti

    

    

        
            
            ↑
            
        
        
Positive

    

    

        B

        
Grado

    




        


        
        

        
        
        

            

  
Dosage & Usage





            
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units


            
            

                
Dosaggi di uso comune

                

                    
                    

                        
general:

                        
8-11 mg/day (RDA)

                    

                    
                    

                        
postbariatric:

                        
16-22 mg/day

                    

                    
                    

                        
metabolicsupport:

                        
15-30 mg/day

                    

                    
                

                
                

                    Limite massimo: 40 mg/day (long-term); higher doses may cause copper depletion
                

                
            

            

            

            
            

                Momento migliore per l'assunzione: With meals to minimize nausea; avoid taking with iron or calcium simultaneously
            

            
        

        

        
        
        

            

  
Safety & Side Effects





            

                
                

                    
Effetti collaterali segnalati

                    
    
                        
                        
  • 
                            ⚠
                            Nausea
                        
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  • 
                            ⚠
                            Vomiting (on empty stomach)
                        
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  • 
                            ⚠
                            Copper depletion (long-term high dose)
                        
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  • 
                            ⚠
                            Metallic taste
                        
    • 
                        
                    

                

                

                
                

                    
Interazioni note

                    
    
                        
                        
  • 
                            ●
                            Antibiotics (reduced absorption — take 2 hours apart)
                        
    • 
                        
                        
  • 
                            ●
                            Penicillamine (reduced absorption)
                        
    • 
                        
                        
  • 
                            ●
                            Iron supplements (competitive absorption)
                        
    • 
                        
                        
  • 
                            ●
                            Calcium supplements (competitive absorption)
                        
    • 
                        
                    

                

                

                
                

                    

                        Livello di assunzione massimo tollerabile: 40 mg/day (long-term); higher doses may cause copper depletion
                    

                

                
            

            

                Consultare sempre il proprio medico prima di iniziare qualsiasi integratore.Consultate sempre il vostro medico prima di iniziare qualsiasi integratore.
            

        

        

        
        
        

            

  
Frequently Asked Questions





            




    
    

        
            Does Zinc help with Insulin Resistance?
            
        
        

            Based on 27 studies with 1,652 participants, there is moderate evidence from clinical studies that Zinc may support Insulin Resistance management. Our evidence grade is B (Good Evidence).
        

    

    
    

        
            How much Zinc should I take for Insulin Resistance?
            
        
        

            Studies have used various dosages. A commonly studied range is 8-11 mg/day (RDA). Always consult your healthcare provider before starting any supplement regimen.
        

    

    
    

        
            Are there side effects of Zinc?
            
        
        

            Reported side effects may include Nausea, Vomiting (on empty stomach), Copper depletion (long-term high dose), Metallic taste. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
        

    

    
    

        
            How strong is the evidence for Zinc and Insulin Resistance?
            
        
        

            We rate the evidence as Grade B (Good Evidence). This rating is based on 27 peer-reviewed studies with 1,652 total participants. The overall direction of effect is positive.
        

    

    




        

        

        
        
        

            

  
Related Evidence





            

                
                
                

                
            

        

        

    


    
    












    

        Avvertenza FDA:
        Queste affermazioni non sono state valutate dalla Food and Drug Administration. I prodotti e le informazioni presenti su questo sito web non sono destinati a diagnosticare, trattare, curare o prevenire alcuna malattia. I gradi di evidenza presentati si basano sulla nostra analisi della ricerca pubblicata e sottoposta a revisione paritaria e non costituiscono consulenza medica. Consultate sempre il vostro medico prima di iniziare qualsiasi regime di integrazione.