What is the recommended dosage for Zinc?

General: 8-11 mg/day (RDA); Post Bariatric: 16-22 mg/day; Metabolic Support: 15-30 mg/day

What are the side effects of Zinc?

Potential side effects include: Nausea, Vomiting (on empty stomach), Copper depletion (long-term high dose), Metallic taste.

What is zinc and how may it relate to weight management?

Zinc is an essential trace mineral involved in immune function, protein synthesis, and hormone regulation, including insulin and leptin. Some research suggests that zinc supplementation may help improve insulin sensitivity and leptin signaling in individuals with zinc deficiency, which may indirectly support metabolic health.

What dosage of zinc has been studied for metabolic outcomes?

Clinical trials on metabolic parameters have used 20–50 mg of elemental zinc per day, typically as zinc gluconate, zinc sulfate, or zinc picolinate. The RDA is 8–11 mg for adults. The tolerable upper intake level is 40 mg per day for adults. Study durations ranged from 4 to 12 weeks.

What are the potential side effects of zinc supplements?

Common side effects include nausea, vomiting, and metallic taste, especially on an empty stomach. Long-term zinc supplementation above 40 mg daily can cause copper deficiency, leading to anemia and neurological problems. Zinc may reduce absorption of antibiotics and penicillamine if taken simultaneously.

Zinc
Zinc

vitamin_mineral

別名: Zinc Picolinate, Zinc Gluconate, Zinc Citrate, Zinc Acetate, Zinc Monomethionine

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About

An essential trace mineral required for leptin synthesis, insulin processing, and thyroid hormone production. Meta-analyses of 27 RCTs demonstrate zinc supplementation may support healthy body weight and insulin sensitivity, with effects most pronounced in deficient and obese individuals.

How It Works

Essential trace mineral required for leptin synthesis, insulin processing and secretion, thyroid hormone production (zinc-dependent deiodinase enzymes), and taste/smell acuity (zinc-dependent gustin protein). Zinc deficiency impairs appetite regulation, reduces metabolic rate through hypothyroidism, and promotes insulin resistance. Zinc also modulates adipokine secretion from adipose tissue.

Evidence For Conditions

症状・状態	グレード	研究数	参加者数
Insulin Resistance	B	27	1652	詳細を見る →

Side Effects

Nausea
Vomiting (on empty stomach)
Copper depletion (long-term high dose)
Metallic taste

Drug & Supplement Interactions

Antibiotics (reduced absorption — take 2 hours apart)
Penicillamine (reduced absorption)
Iron supplements (competitive absorption)
Calcium supplements (competitive absorption)

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Related Ingredients

B-Complex Iron Magnesium Omega-3 Vitamin B12

基本情報

用量: General: 8-11 mg/day (RDA); Post_Bariatric: 16-22 mg/day; Metabolic_Support: 15-30 mg/day
剤形: capsule tablet lozenge liquid
天然の供給源: Oysters, Red meat, Poultry, Beans, Nuts, Pumpkin seeds, Dark chocolate
上限量: 40 mg/day (long-term); higher doses may cause copper depletion
推奨摂取タイミング: With meals to minimize nausea; avoid taking with iron or calcium simultaneously

エビデンスの要約

Insulin Resistance B

FDAに関する免責事項: これらの記述は米国食品医薬品局（FDA）による評価を受けていません。本ウェブサイトの製品および情報は、疾病の診断、治療、治癒、または予防を目的としたものではありません。表示されているエビデンスグレードは、公開された査読済み研究の分析に基づいており、医療上の助言を構成するものではありません。サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。