Vitamin DVitamin D
hormonal
别名: Cholecalciferol (D3), Ergocalciferol (D2), Calciferol
About
A fat-soluble vitamin with receptors in adipose tissue, skeletal muscle, and the pancreas. Mendelian randomization studies confirm a causal association between low vitamin D levels and higher BMI, and meta-analyses support supplementation for metabolic health in deficient individuals.
How It Works
Vitamin D receptors are expressed in adipose tissue, skeletal muscle, and the pancreas. Adequate vitamin D status supports insulin sensitivity, leptin signaling, and calcium-mediated fat oxidation. Deficiency (25(OH)D <20 ng/mL) is independently associated with obesity, insulin resistance, and increased visceral fat — potentially through impaired adipocyte differentiation and increased parathyroid hormone (PTH).
Evidence For Conditions
| 健康状况 | 等级 | 研究数量 | 受试者 | |
|---|---|---|---|---|
| PCOS-Related Weight Management | B | 12 | 800 | 查看 → |
| Obesity | B | 11 | 947 | 查看 → |
| Menopause-Related Weight Gain | C | 6 | 500 | 查看 → |
Side Effects
- Hypercalcemia (at very high doses)
- Nausea
- Kidney stones (at excessive doses)
Drug & Supplement Interactions
- Statins (may increase statin levels)
- Thiazide diuretics (increased calcium risk)
- Corticosteroids (impair vitamin D metabolism)
- Orlistat (reduced absorption)
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Related Ingredients
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