エビデンスに基づいた サプリメントレビュー
Every weight claim cited.
We read the weight management studies so you don't have to.
Evidence-based supplement research you can trust. We analyze peer-reviewed clinical studies from PubMed and grade every supplement ingredient on a transparent A–D scale. No sponsored rankings, no manufacturer influence — just science.
Featured Ingredients
Glucomannan
fiber_satietyWater-soluble dietary fiber that absorbs up to 50 times its weight in water, forming a viscous gel in the stomach. …
Berberine
fat_metabolismActivates AMP-activated protein kinase (AMPK), the master metabolic regulator, in muscle, liver, and adipose tissue — a mechanism shared with …
Ashwagandha
hormonalWithanolide-rich adaptogen that modulates the hypothalamic-pituitary-adrenal (HPA) axis, reducing cortisol levels by 14-28% in clinical trials. Chronic cortisol elevation promotes …
Vitamin D
hormonalVitamin D receptors are expressed in adipose tissue, skeletal muscle, and the pancreas. Adequate vitamin D status supports insulin sensitivity, …
Probiotics (Lactobacillus gasseri)
gut_healthStrain-specific probiotic that modulates the gut-brain-adipose axis. L. gasseri SBT2055 reduces dietary fat absorption by increasing fecal fat excretion (by …
Green Tea Extract (EGCG)
thermogenicEpigallocatechin gallate (EGCG) inhibits catechol-O-methyltransferase (COMT), prolonging norepinephrine signaling and increasing thermogenesis and fat oxidation. Also activates AMPK, which promotes …
Top Conditions
Obesity
42.4% of US adults (2023 CDC data); 650 million adults globally; prevalence has tripled since 1975
Overweight Management
30.7% of US adults; combined with obesity, 73.1% of US adults are overweight or obese
Metabolic Syndrome
34.7% of US adults (NHANES); increases with age: 50% in those >60 years
Insulin Resistance
40% of US adults aged 18-44 (estimated); up to 70% in obese individuals
Abdominal Fat Reduction
54% of US adults have elevated waist circumference; visceral obesity increasing even among normal-weight individuals
Appetite Control
Subjective hunger and appetite dysregulation affect the majority of individuals attempting weight loss
Recent Evidence Updates
Guides & Resources
Managing Weight Loss Plateaus: Science and Strategies
Weight loss plateaus are among the most frustrating and misunderstood aspects of the weight management journey, yet they are a near-universal experience and a physiologically …
lifestyleExercise and Supplements: An Evidence-Based Approach
Regular physical activity is the single most impactful modifiable factor for long-term weight management success. Meta-analyses of weight loss maintenance studies consistently show that individuals …
safetyWeight Loss Supplement Interactions with Medications
Drug-supplement interactions represent one of the most underappreciated safety concerns in weight management. A 2016 survey published in JAMA Internal Medicine found that more than …
Evidence Grading System
Every supplement claim on this site is graded on an A–D scale based on peer-reviewed clinical research from PubMed. Our algorithm evaluates study design (RCTs rank highest), consistency of results, sample sizes, and the overall body of evidence. No manufacturer sponsorship influences our grades.
Multiple randomized controlled trials (RCTs) or meta-analyses with consistent positive results and large sample sizes.
At least one RCT with mostly consistent results across studies. Evidence suggests benefit but more research may be needed.
Small studies or observational data with some positive signals. Promising but insufficient for strong recommendations.
In vitro studies, case reports, or pilot studies only. Early-stage research that requires clinical validation.
How It Works
広告なし。スポンサーランキングなし。科学だけ。
リサーチハブ
サプリメント成分に関するすべての臨床研究を PubMed で検索しています。
抽出
主要な知見(サンプルサイズ、研究タイプ、結果)を抽出しています。
グレード A から F
エビデンスを通知表のようにグレード付けします — A(強い)から F(否定的)まで。
明確な答え
数秒で明確な答えが得られます — このサプリメントは実際に効果が期待できるのか?
Cited Health Network
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FDAに関する免責事項: これらの記述は米国食品医薬品局(FDA)による評価を受けていません。本ウェブサイトの製品および情報は、疾病の診断、治療、治癒、または予防を目的としたものではありません。表示されているエビデンスグレードは、公開された査読済み研究の分析に基づいており、医療上の助言を構成するものではありません。サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。