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WeightCited

Zinc ： Insulin Resistance

B

Meta-analysis of 27 RCTs (n=1,652) found zinc supplementation significantly reduced body weight (0.63 kg), BMI, waist circumference, and HOMA-IR. Separate meta-analysis found significant reductions in fasting glucose, HbA1c, and insulin. Effects are strongest in deficient and obese individuals.

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            B

        

        

            
結論

            
            
Meta-analysis of 27 RCTs (n=1,652) found zinc supplementation significantly reduced body weight (0.63 kg), BMI, waist circumference, and HOMA-IR. Separate meta-analysis found significant reductions in fasting glucose, HbA1c, and insulin. Effects are strongest in deficient and obese individuals.

            
            
        

    











    
    

        
        

            

  
Key Statistics





            


    

        
27

        
研究数

    

    

        
1652

        
参加者数

    

    

        
            
            ↑
            
        
        
Positive

    

    

        B

        
グレード

    




        


        
        

        
        
        

            

  
Dosage & Usage





            
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units


            
            

                
一般的な使用量

                

                    
                    

                        
general:

                        
8-11 mg/day (RDA)

                    

                    
                    

                        
postbariatric:

                        
16-22 mg/day

                    

                    
                    

                        
metabolicsupport:

                        
15-30 mg/day

                    

                    
                

                
                

                    上限量： 40 mg/day (long-term); higher doses may cause copper depletion
                

                
            

            

            

            
            

                推奨摂取タイミング： With meals to minimize nausea; avoid taking with iron or calcium simultaneously
            

            
        

        

        
        
        

            

  
Safety & Side Effects





            

                
                

                    
報告されている副作用

                    
    
                        
                        
  • 
                            ⚠
                            Nausea
                        
    • 
                        
                        
  • 
                            ⚠
                            Vomiting (on empty stomach)
                        
    • 
                        
                        
  • 
                            ⚠
                            Copper depletion (long-term high dose)
                        
    • 
                        
                        
  • 
                            ⚠
                            Metallic taste
                        
    • 
                        
                    

                

                

                
                

                    
既知の相互作用

                    
    
                        
                        
  • 
                            ●
                            Antibiotics (reduced absorption — take 2 hours apart)
                        
    • 
                        
                        
  • 
                            ●
                            Penicillamine (reduced absorption)
                        
    • 
                        
                        
  • 
                            ●
                            Iron supplements (competitive absorption)
                        
    • 
                        
                        
  • 
                            ●
                            Calcium supplements (competitive absorption)
                        
    • 
                        
                    

                

                

                
                

                    

                        耐容上限摂取量： 40 mg/day (long-term); higher doses may cause copper depletion
                    

                

                
            

            

                サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。
            

        

        

        
        
        

            

  
Frequently Asked Questions





            




    
    

        
            Does Zinc help with Insulin Resistance?
            
        
        

            Based on 27 studies with 1,652 participants, there is moderate evidence from clinical studies that Zinc may support Insulin Resistance management. Our evidence grade is B (Good Evidence).
        

    

    
    

        
            How much Zinc should I take for Insulin Resistance?
            
        
        

            Studies have used various dosages. A commonly studied range is 8-11 mg/day (RDA). Always consult your healthcare provider before starting any supplement regimen.
        

    

    
    

        
            Are there side effects of Zinc?
            
        
        

            Reported side effects may include Nausea, Vomiting (on empty stomach), Copper depletion (long-term high dose), Metallic taste. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
        

    

    
    

        
            How strong is the evidence for Zinc and Insulin Resistance?
            
        
        

            We rate the evidence as Grade B (Good Evidence). This rating is based on 27 peer-reviewed studies with 1,652 total participants. The overall direction of effect is positive.
        

    

    




        

        

        
        
        

            

  
Related Evidence





            

                
                
                

                
            

        

        

    


    
    












    

        FDAに関する免責事項:
        これらの記述は米国食品医薬品局（FDA）による評価を受けていません。本ウェブサイトの製品および情報は、疾病の診断、治療、治癒、または予防を目的としたものではありません。表示されているエビデンスグレードは、公開された査読済み研究の分析に基づいており、医療上の助言を構成するものではありません。サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。