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Iron ： Hypothyroid-Related Weight Gain

C

Iron is required for thyroid peroxidase (TPO), and iron deficiency impairs T4-to-T3 conversion and thyroid hormone synthesis. Meta-analysis of 22 RCTs found correction of iron deficiency improves exercise tolerance and VO2max. Supplement only when deficiency is confirmed.

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            C

        

        

            
結論

            
            
Iron is required for thyroid peroxidase (TPO), and iron deficiency impairs T4-to-T3 conversion and thyroid hormone synthesis. Meta-analysis of 22 RCTs found correction of iron deficiency improves exercise tolerance and VO2max. Supplement only when deficiency is confirmed.

            
            
        

    











    
    

        
        

            

  
Key Statistics





            


    

        
22

        
研究数

    

    

        
2000

        
参加者数

    

    

        
            
            ↑
            
        
        
Positive

    

    

        C

        
グレード

    




        


        
        

        
        
        

            

  
Dosage & Usage





            
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units


            
            

                
一般的な使用量

                

                    
                    

                        
general:

                        
8-18 mg/day (RDA)

                    

                    
                    

                        
menstruatingwomen:

                        
18 mg/day

                    

                    
                    

                        
deficiencycorrection:

                        
100-200 mg elemental iron/day under medical guidance

                    

                    
                

                
                

                    上限量： 45 mg/day (elemental iron); excess iron increases oxidative stress
                

                
            

            

            

            
            

                推奨摂取タイミング： On empty stomach with vitamin C for absorption; avoid with calcium, coffee, tea
            

            
        

        

        
        
        

            

  
Safety & Side Effects





            

                
                

                    
報告されている副作用

                    
    
                        
                        
  • 
                            ⚠
                            Constipation
                        
    • 
                        
                        
  • 
                            ⚠
                            Nausea
                        
    • 
                        
                        
  • 
                            ⚠
                            Stomach pain
                        
    • 
                        
                        
  • 
                            ⚠
                            Black stools
                        
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  • 
                            ⚠
                            Oxidative stress (excess iron)
                        
    • 
                        
                    

                

                

                
                

                    
既知の相互作用

                    
    
                        
                        
  • 
                            ●
                            Levothyroxine (reduced absorption — take 4 hours apart)
                        
    • 
                        
                        
  • 
                            ●
                            Tetracycline antibiotics (reduced absorption)
                        
    • 
                        
                        
  • 
                            ●
                            Calcium supplements (reduced absorption)
                        
    • 
                        
                        
  • 
                            ●
                            Proton pump inhibitors (reduced absorption)
                        
    • 
                        
                    

                

                

                
                

                    

                        耐容上限摂取量： 45 mg/day (elemental iron); excess iron increases oxidative stress
                    

                

                
            

            

                サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。
            

        

        

        
        
        

            

  
Frequently Asked Questions





            




    
    

        
            Does Iron help with Hypothyroid-Related Weight Gain?
            
        
        

            Based on 22 studies with 2,000 participants, there is limited but promising evidence that Iron may support Hypothyroid-Related Weight Gain management. Our evidence grade is C (Some Evidence).
        

    

    
    

        
            How much Iron should I take for Hypothyroid-Related Weight Gain?
            
        
        

            Studies have used various dosages. A commonly studied range is 8-18 mg/day (RDA). Always consult your healthcare provider before starting any supplement regimen.
        

    

    
    

        
            Are there side effects of Iron?
            
        
        

            Reported side effects may include Constipation, Nausea, Stomach pain, Black stools. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
        

    

    
    

        
            How strong is the evidence for Iron and Hypothyroid-Related Weight Gain?
            
        
        

            We rate the evidence as Grade C (Some Evidence). This rating is based on 22 peer-reviewed studies with 2,000 total participants. The overall direction of effect is positive.
        

    

    




        

        

        
        
        

            

  
Related Evidence





            

                

                
                
                
            

        

        

    


    
    












    

        FDAに関する免責事項:
        これらの記述は米国食品医薬品局（FDA）による評価を受けていません。本ウェブサイトの製品および情報は、疾病の診断、治療、治癒、または予防を目的としたものではありません。表示されているエビデンスグレードは、公開された査読済み研究の分析に基づいており、医療上の助言を構成するものではありません。サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。